Thalamic development induced by Shh in the chick embryo

Vieira, Claudia; Garda, A.L.; Shimamura, Kenji; Martı́nez, Salvador

doi:10.1016/j.ydbio.2005.05.031

Cited by 93 publications

(128 citation statements)

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“…The identities of the prosomeres are established early during patterning of the neuroepithelium and are manifested by the expression of domain-specific transcription factors, including Fez (Fezf1/2; in P3), Irx3 and Otx2 (in P2). Later, Zli is an important source of the morphogen Shh, which is crucial for further patterning of both the developing prethalamus and thalamus (Hashimoto-Torii et al, 2003;Jeong et al, 2011;Kiecker and Lumsden, 2004;Scholpp et al, 2007;Vieira et al, 2005;Vue et al, 2009). Other local signals regulating thalamic development include fibroblast growth factors and Wnts (Braun et al, 2003;Kataoka and Shimogori, 2008;Martinez-Ferre and Martinez, 2009;Zhou et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Transcriptional regulatory mechanisms underlying the GABAergic neuron fate in different diencephalic prosomeres

et al. 2012

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SUMMARYDiverse mechanisms regulate development of GABAergic neurons in different regions of the central nervous system. We have addressed the roles of a proneural gene, Ascl1, and a postmitotic selector gene, Gata2, in the differentiation of GABAergic neuron subpopulations in three diencephalic prosomeres: prethalamus (P3), thalamus (P2) and pretectum (P1). Although the different proliferative progenitor populations of GABAergic neurons commonly express Ascl1, they have distinct requirements for it in promotion of cell-cycle exit and GABAergic neuron identity. Subsequently, Gata2 is activated as postmitotic GABAergic precursors are born. In P1, Gata2 regulates the neurotransmitter identity by promoting GABAergic and inhibiting glutamatergic neuron differentiation. Interestingly, Gata2 defines instead the subtype of GABAergic neurons in the rostral thalamus (pTh-R), which is a subpopulation of P2. Without Gata2, the GABAergic precursors born in the pTh-R fail to activate subtype-specific markers, but start to express genes typical of GABAergic precursors in the neighbouring P3 domain. Thus, our results demonstrate diverse mechanisms regulating differentiation of GABAergic neuron subpopulations and suggest a role for Gata2 as a selector gene of both GABAergic neuron neurotransmitter and prosomere subtype identities in the developing diencephalon. Our results demonstrate for the first time that neuronal identities between distinct prosomeres can still be transformed in postmitotic neuronal precursors.

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Section: Introductionmentioning

confidence: 99%

Transcriptional regulatory mechanisms underlying the GABAergic neuron fate in different diencephalic prosomeres

et al. 2012

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“…In the diencephalic neuroepithelium, Shh shows an intriguing and dynamic pattern of expression with domains in the caudal-dorsal diencephalon [zona limitans interthalamica (ZLI)] and the rostral-ventral diencephalon (hypothalamic domain), which seem strategically situated to influence the formation of the DTJ. In the caudal diencephalon, neural Shh from the ZLI specifies the prethalamus (PTh) (Hashimoto-Torii et al, 2003;Kiecker and Lumsden, 2004;Vieira et al, 2005;Hirata et al, 2006;Scholpp et al, 2006;Guinazu et al, 2007) and promotes growth and differentiation of specific subdivisions of the thalamus (Szabó et al, 2009). The role of neural Shh in the rostral diencephalon (hypothalamus) and DTJ, however, is only starting to be analyzed.…”

Section: Introductionmentioning

confidence: 99%

Role of NeuroepithelialSonic hedgehogin Hypothalamic Patterning

et al. 2009

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The hypothalamus is a region of the diencephalon with particularly complex patterning. Sonic hedgehog (Shh), encoding a protein with key developmental roles, shows a peculiar and dynamic diencephalic expression pattern. Here, we use transgenic strategies and in vitro experiments to test the hypothesis that Shh expressed in the diencephalic neuroepithelium (neural Shh) coordinates tissue growth and patterning in the hypothalamus. Our results show that neural Shh coordinates anteroposterior and dorsoventral patterning in the hypothalamus and in the diencephalon-telencephalon junction. Neural Shh also coordinates mediolateral hypothalamic patterning, since it is necessary for the lateral hypothalamus to attain proper size and is required for the specification of hypocretin/orexin cells. Finally, neural Shh is necessary to maintain expression of differentiation markers including survival factor Foxb1.

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“…This pre-epichordal planar interaction in the alar plate would induce the conditions which permit the expression of Shh in the ZLI and would activate the morphogenetic properties of this organizer, specifying in turn the compartmentalization and cell fate of the different diencephalic prosomeres, through the control of specific gene expression ( Fig. 4; Kobayashi et al, 2002;Vieira et al, 2005). The pattern of Shh expression in the ZLI is very dynamic in both mouse and chick embryos (Echelard et al, 1993;Shimamura et al, 1995;Fig.…”

Section: Zona Limitans Intrathalamica (Zli)mentioning

confidence: 99%

“…The expression of molecules such as Mkp3/Sef and those belonging to the sprouty (Spry) family are induced by Fgf8 expression in the organizers (Fig. 5) and may determine the spatial reduction of Fgf8 activity in a gradient manner by interaction with the intracellular mechanism of the MAP kinase cascade (Furthauer et al, 2002;Tsang and Dawid, 2004;Echevarria et al, 2005a;Vieira et al, 2005; for review see Echevarria et al, 2005b). In particular, the negative feedback modulator of Fgf8 signaling, Mkp3, selectively inactivates the ERK1/2 class of MAP kinases by dephosphorylation leading to catalytic inactivation.…”

Section: Fgf Signaling Pathwaymentioning

confidence: 99%

Molecular mechanisms controlling brain development: an overview of neuroepithelial secondary organizers

Vieira¹,

Pombero²,

et al. 2010

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. In this review, we will describe the principle aspects of CNS development in birds and mammals, starting from early stages of embryogenesis (gastrulation and neurulation) and culminating with the formation of a variety of different regions which contribute to the structural complexity of the brain (regionalization and morphogenesis). We will pay special attention to the cellular and molecular mechanisms involved in neural tube regionalization and the key role played by localized secondary organizers in the patterning of neural primordia. KEY WORDS: patterning, neural plate, neural tube, gastrulation, neurulation, secondary organizer, anterior neural ridge, zona limitans intrathalamica, isthmic organizer Neural plate and neural tube formationA fundamental early step in neural development is the allocation of a group of ectodermal cells as precursors of the entire nervous system (Hemmati-Brivanlou and Melton, 1997). This process involves an inductive interaction first demonstrated in amphibian embryos by Spemann and Mangold in the 1920's (see Spemann and Mangold, 2001). Their experiments which involved the grafting of differently pigmented species of newt established the concept of neural induction as an instructive interaction between the dorsal lip of the blastopore (the "organizer") and the neighboring ectoderm. The discovery of a neural organization center for the amphibian gastrula initiated a search for homologous structures in other vertebrates. Soon thereafter, the equivalent region was discovered in most vertebrate species, including the shield of teleosts. In birds and mammals, the region was named "Hensen's node" and "the node", respectively. When C.H. Waddington transplanted the Hensen node of a chick embryo, he observed the induction of Int. J. Dev. Biol. 54: 7-20 (2010) Abbreviations used in this paper: ANR, anterior neural ridge; AP, anteroposterior; BMP, bone morphogenetic protein; DV, dorso-ventral; FGF, fibroblast growth factor; IsO, Isthmic organizer; ML, medio-lateral; TGF, transforming growth factor; ZLI, zona limitans intrathalamica.an ectopic neural plate or the formation of a partial new embryonic axis containing neural tube, notochord and somites (Waddington, 1933;Waddington, 1936). This demonstration provided the first evidence that in chick embryos, the nervous system is induced by signals from non-neural cells. Recent works demonstrated that the capacity of ectodermal cells to undergo neural differentiation represents their default state. In fact, neural differentiation must be suppressed in the lateral ectoderm by signals transmitted between neighboring cells, in order to develop as epidermis. These molecular signals are members of the bone morphogenetic protein (BMP) subclass of transforming growth factor β (TGF-β)-related proteins (for review see Wittler and Kessel, 2004). C. Vieira et al.Recent studies using chick embryos have shown that neural induction really begins prior to the formation of the organizer region and thus must be initiated by signals derived from other cellul...

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Thalamic development induced by Shh in the chick embryo

Cited by 93 publications

References 50 publications

Transcriptional regulatory mechanisms underlying the GABAergic neuron fate in different diencephalic prosomeres

Transcriptional regulatory mechanisms underlying the GABAergic neuron fate in different diencephalic prosomeres

Role of NeuroepithelialSonic hedgehogin Hypothalamic Patterning

Molecular mechanisms controlling brain development: an overview of neuroepithelial secondary organizers

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