Thalamic and Subcortical Gliosis With Dementia

Morbid Risk to First Degree Relatives of Neuropathologically Confirmed Cases of Alzheimer's Disease

“…These include dysphagic dementias and Pick's disease [41.42], progressive thalamic and subcortical gliosis [43], Gcrtzman-Straussler disease [44][45][46], Creutzfelt-Jacob disease [47][48][49], as well as dementia associated with non specific neuropalhological features [50]. Indeed, 2 of 7 non-AD dementia cases with nonspecific neuropathological features in the present series showed a positive family history for PPD.…”

Morbid Risk to First Degree Relatives of Neuropathologically Confirmed Cases of Alzheimer's Disease

“…These include dysphagic dementias and Pick's disease [41.42], progressive thalamic and subcortical gliosis [43], Gcrtzman-Straussler disease [44][45][46], Creutzfelt-Jacob disease [47][48][49], as well as dementia associated with non specific neuropalhological features [50]. Indeed, 2 of 7 non-AD dementia cases with nonspecific neuropathological features in the present series showed a positive family history for PPD.…”

A Unique Autosomal Dominant Disorder with Indifference to Pain: Clinicopathologic Correlation of Indifference to Pain and Thalamic Gliosis

“…The neuropathological substrate in selective thalamic degenerations is most often spongioform change related to prion disease [34,38] or nonspecific neuronal loss and gliosis [36,37]. However, the clinical phenotype of these thalamic syndromes is similar to our family with early behavioral changes and psychiatric disturbances.…”

Frontotemporal dementia with severe thalamic involvement: a clinical and neuropathological study

“…In the latter, they may appear in association with motor neuron disease 19 or a more diffuse subcortical atrophy, frequently being familial in character. Since the degenerative alterations frequently spread to other subcortical structures, the term "subcortical gliosis" is also applied to such cases of progressive dementia associated with variable cortical neuronal loss and subcortical / deep white matter gliosis [20][21][22] . The thalamus has massive connections with the frontal lobes, the limbic system and the activating reticular formation of the brainstem, and these connections are directly related to the mechanisms of behavioral control, emotions and memory.…”

Morbid Risk to First Degree Relatives of Neuropathologically Confirmed Cases of Alzheimer's Disease

“…These include dysphagic dementias and Pick's disease [41.42], progressive thalamic and subcortical gliosis [43], Gcrtzman-Straussler disease [44][45][46], Creutzfelt-Jacob disease [47][48][49], as well as dementia associated with non specific neuropalhological features [50]. Indeed, 2 of 7 non-AD dementia cases with nonspecific neuropathological features in the present series showed a positive family history for PPD.…”

A Unique Autosomal Dominant Disorder with Indifference to Pain: Clinicopathologic Correlation of Indifference to Pain and Thalamic Gliosis

“…The neuropathological substrate in selective thalamic degenerations is most often spongioform change related to prion disease [34,38] or nonspecific neuronal loss and gliosis [36,37]. However, the clinical phenotype of these thalamic syndromes is similar to our family with early behavioral changes and psychiatric disturbances.…”

Frontotemporal dementia with severe thalamic involvement: a clinical and neuropathological study

“…In the latter, they may appear in association with motor neuron disease 19 or a more diffuse subcortical atrophy, frequently being familial in character. Since the degenerative alterations frequently spread to other subcortical structures, the term "subcortical gliosis" is also applied to such cases of progressive dementia associated with variable cortical neuronal loss and subcortical / deep white matter gliosis [20][21][22] . The thalamus has massive connections with the frontal lobes, the limbic system and the activating reticular formation of the brainstem, and these connections are directly related to the mechanisms of behavioral control, emotions and memory.…”

Morbid Risk to First Degree Relatives of Neuropathologically Confirmed Cases of Alzheimer's Disease

“…These include dysphagic dementias and Pick's disease [41.42], progressive thalamic and subcortical gliosis [43], Gcrtzman-Straussler disease [44][45][46], Creutzfelt-Jacob disease [47][48][49], as well as dementia associated with non specific neuropalhological features [50]. Indeed, 2 of 7 non-AD dementia cases with nonspecific neuropathological features in the present series showed a positive family history for PPD.…”

A Unique Autosomal Dominant Disorder with Indifference to Pain: Clinicopathologic Correlation of Indifference to Pain and Thalamic Gliosis

“…The neuropathological substrate in selective thalamic degenerations is most often spongioform change related to prion disease [34,38] or nonspecific neuronal loss and gliosis [36,37]. However, the clinical phenotype of these thalamic syndromes is similar to our family with early behavioral changes and psychiatric disturbances.…”

Frontotemporal dementia with severe thalamic involvement: a clinical and neuropathological study

“…In the latter, they may appear in association with motor neuron disease 19 or a more diffuse subcortical atrophy, frequently being familial in character. Since the degenerative alterations frequently spread to other subcortical structures, the term "subcortical gliosis" is also applied to such cases of progressive dementia associated with variable cortical neuronal loss and subcortical / deep white matter gliosis [20][21][22] . The thalamus has massive connections with the frontal lobes, the limbic system and the activating reticular formation of the brainstem, and these connections are directly related to the mechanisms of behavioral control, emotions and memory.…”