Th1 cytokines in oral lichen planus

Khan, Ambereen; Farah, Camile S.; Savage, N. W.; Walsh, L. J.; Harbrow, D.; Sugerman, Philip B.

doi:10.1034/j.1600-0714.2003.00077.x

Cited by 206 publications

(202 citation statements)

References 42 publications

Supporting

Mentioning

172

Contrasting

Unclassified

Order By: Relevance

“…33,34 In the present study, all of the patients were inpatients. All of the patients and controls were instructed not to eat one hour prior to the sampling.…”

Section: Discussionmentioning

confidence: 89%

Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma

Sato¹,

Goto²,

Murata³

et al. 2010

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

View full text Add to dashboard Cite

Objective: To elucidate the changes in interleukin-6 (IL-6) levels in whole saliva during the treatment phase in patients with oral squamous cell carcinoma (OSCC).Study Design: Twenty-nine consecutive inpatients with OSCC were enrolled in this study. Stimulated saliva was collected three times (just after hospitalization)[period 1], just before main treatment (surgery: 26/29 cases)[period 2] and at the time of discharge [period 3]. The mean intervals were 11±8 days between periods 1 and 2 and 30±18 days between periods 2 and 3. As controls, 19 age-matched healthy volunteers were also recruited. IL-6 concentrations were measured by a highly sensitive chemiluminescent enzyme immunoassay.

show abstract

“…33,34 In the present study, all of the patients were inpatients. All of the patients and controls were instructed not to eat one hour prior to the sampling.…”

Section: Discussionmentioning

confidence: 89%

Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma

Sato¹,

Goto²,

Murata³

et al. 2010

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

View full text Add to dashboard Cite

show abstract

“…The pathophysiology of OLP is multifarious and in the microscopic evaluation, its features are associated with pathognomonic characteristics and degeneration of cells which is supposed to be certified to associate epithelial permeation of T-lymphocytes leading to local production of cytokines (Khan et al, 2003). Recently, it has been stated that the imbalance in levels of free radical and ROS with antioxidants may play an important role in the start of several inflammatory oral disease (Hosseini et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Uric Acid, Total Antioxidant and Lipid Peroxidation Parameters in Serum and Saliva of Patients with Oral Lichen Planus

Shiva¹,

Arab²

2016

GJHS

View full text Add to dashboard Cite

Background: Oral lichen planus (OLP) is a chronic and inflammation mucosal disease. Reactive Oxygen Species (ROS) and oxidative stress damage might be the cause. Malondialdehyd (MDA), one parameter of lipid peroxidation is appropriate for DNA damage in OLP disease.Objective: To evaluate antioxidants and oxidative stress parameters in patients with oral lichen planus (OLP) diseases and healthy control group with compare on serum and salivary samples. Material & Methods:The research population included 22 patients with OLP which recently diagnosed and 22 healthy controls matched for periodontal status. Total antioxidant activity (TAA), Malondialdehyde (MDA) or lipid peroxidation product and uric acid (UA) were evaluated in both serum and saliva. The t-tests were used for differences between the two groups in normal distributed variables and also Spearman's rho correlation coefficient for assessing association between serum and salivary fluids.Results: TAA levels in OLP patients showed significant result and lower than healthy control group (p=0.39). Also, results in the saliva MDA concentration, was significantly higher in OLP patients than controls. In correlation test, inverse and significant correlation was observed between the MDA and UA values(r=0. 682, P=0.0001) and a significant correlation was found between serum TAA and UA values. Conclusion:This study showed that OLP groups have higher cellular lipid peroxidation in compare to healthy controls and low level of TAA than controls. Patients with OLP are believed to be more at risk of antioxidant-oxidative stress imbalance.

show abstract

“…In various reports, it has been emphasized that IFN-γ and TNF-α are proinflammatory cytokines, that TNF-α reduces IFN-γ secretion, and that these cytokines play an active part in the clinical type and disease activity in LP. Although the findings obtained in the above-mentioned study were not compared with a control group, it has been reported that TNF-α expression increased whereas IFN-γ expression decreased [29].…”

Section: Discussionmentioning

confidence: 99%

Possible Role of TNF-α, IFN-γ, FAS/APO1 in the Etiopathogenesis of Lichen Planus

2015

J Turk Acad Dermatol

View full text Add to dashboard Cite

show abstract

Th1 cytokines in oral lichen planus

Abstract: These data suggest the development of a T helper 1 immune response that may promote CD8+ cytotoxic T-cell activity in OLP.

Cited by 206 publications

References 42 publications

Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma

Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma

Evaluation of Uric Acid, Total Antioxidant and Lipid Peroxidation Parameters in Serum and Saliva of Patients with Oral Lichen Planus

Possible Role of TNF-α, IFN-γ, FAS/APO1 in the Etiopathogenesis of Lichen Planus

Contact Info

Product

Resources

About