Biochemical Pharmacology volume 77, issue 5, P813-825 2009 DOI: 10.1016/j.bcp.2008.10.036 View full text
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Simona Serratì, Francesca Margheri, Marco Pucci, Anna Rita Cantelmo, Rosaria Cammarota, Javier Dotor, Francisco Borràs-Cuesta, Gabriella Fibbi, Adriana Albini, Mario Del Rosso

Abstract: ABSTRACTThe role of transforming growth factor-beta (TGF) in tumor promotion and in angiogenesis is context-dependent. While TGF prevents tumor growth and angiogenesis in early phases of tumor development, evidence is accumulating about its pro-angiogenic and tumor promotion activities in late stages of tumor progression. Here we have studied, in an experimental context previously reported to disclose the pro-