2016
DOI: 10.18632/aging.101050
View full text |Buy / Rent full text
Has erratum 2021-8-31
|
Sign up to set email alerts
|

Abstract: The corneal epithelium plays important roles in the maintenance of corneal transparency for good vision, and acts as a protective barrier against foreign insults. Structural and functional changes with aging in the corneal epithelium have been documented. Here we found that transforming growth factor-β (TGF-β) is highly expressed in the elderly donor corneal epithelium, as are senescence-associated genes, such as p16 and p21. In human corneal epithelial cell (HCEC) models, TGF-β induces cellular senescence, ch… Show more

Help me understand this report
Editorial notices

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

4
17
0

Year Published

2017
2017
2020
2020

Publication Types

Select...
4
1

Relationship

1
4

Authors

Journals

citations
Cited by 29 publications
(54 citation statements)
references
References 49 publications
(54 reference statements)
4
17
0
Order By: Relevance
“…Notwithstanding our findings in this study, TGF‐β induces cellular senescence in human corneal epithelial cells in cooperation with NF‐kB signals . Consistent with this, we already reported that TNF‐α signals cooperate with TGF‐β to induce the EMT in lung cancer A549 cells harboring active K‐Ras mutation, and NF‐kB inhibitor blocks the EMT .…”
Section: Discussionsupporting
confidence: 91%
“…Notwithstanding our findings in this study, TGF‐β induces cellular senescence in human corneal epithelial cells in cooperation with NF‐kB signals . Consistent with this, we already reported that TNF‐α signals cooperate with TGF‐β to induce the EMT in lung cancer A549 cells harboring active K‐Ras mutation, and NF‐kB inhibitor blocks the EMT .…”
Section: Discussionsupporting
confidence: 91%
“…Corneal allografts and MDSCs were lysed in RIPA buffer (Beyotime, Beijing, China) with a protease inhibitor cocktail (Millipore), respectively. Western blot was performed as described previously ( 24 ). The membranes were probed with anti-GAPDH (KC-5G5, Kangchen) and anti-iNOS (ab15323, Abcam) primary antibodies and subsequently reacted with HRP-conjugated secondary antibodies (Pierce, 1:3,000), respectively.…”
Section: Methodsmentioning
confidence: 99%
“…The TGF-β protein has three different isoforms (1-3), located in the extracellular matrix and can regulate several biological cell functions such as proliferation, differentiation, migration, and survival, playing pivotal role in the morphogenesis and homeostasis [ 10 ]. This protein is expressed in different tissues including brain [ 9 ], tumor [ 11 ], corneal epithelium [ 12 ] and muscle [ 13 ]. There are some evidences that links the TGF-β1 levels with obesity and aging in rodents and humans [ 9 , 14 , 15 ].…”
Section: Introductionmentioning
confidence: 99%