2022
DOI: 10.3390/cells11193153
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Abstract: Transcription factor EB (TFEB) is considered the master transcriptional regulator of autophagy and lysosomal biogenesis, which regulates target gene expression through binding to CLEAR motifs. TFEB dysregulation has been linked to the development of numerous pathological conditions; however, several other lines of evidence show that TFEB might be a point of convergence of diverse signaling pathways and might therefore modulate other important biological processes such as cellular senescence, DNA repair, ER str… Show more

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Cited by 28 publications
(10 citation statements)
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“…Notable, nuclear TFEB appeared to have a higher molecular weight than cytosolic TFEB in bladder cancer cell lines. This observation opens the question whether post-translational modifications, such as acetylation, SUMOylation, PARsylation, or glycosylation in addition to phosphorylation 21 , or alternatively, different isoforms of TFEB could be more prevalent in the nuclear fraction of bladder cancer cells. To further test whether this nuclear localization indicated hyperactivation of TFEB in cell lines representing high-grade cancers we performed a GSEA (Gene Set Enrichment Analysis) of the transcriptome of bladder cancer cell lines.…”
Section: Resultsmentioning
confidence: 99%
“…Notable, nuclear TFEB appeared to have a higher molecular weight than cytosolic TFEB in bladder cancer cell lines. This observation opens the question whether post-translational modifications, such as acetylation, SUMOylation, PARsylation, or glycosylation in addition to phosphorylation 21 , or alternatively, different isoforms of TFEB could be more prevalent in the nuclear fraction of bladder cancer cells. To further test whether this nuclear localization indicated hyperactivation of TFEB in cell lines representing high-grade cancers we performed a GSEA (Gene Set Enrichment Analysis) of the transcriptome of bladder cancer cell lines.…”
Section: Resultsmentioning
confidence: 99%
“…Several lines point to the localization of these particular pathways in the proximal tubule, among them the present TUNEL signal and related apoptotic cell features (23,61). With the UPR response also driving regulation of TFEB, an acknowledged master regulator of autophagy and lysosomal biogenesis (64), CsA may hereby induce a blockade in autophagic flux and cause the selective lysosomal disorder that was not observed in Tac. Notably, mTOR inhibitors, commonly employed in combination with CNI, may have a beneficial effect herein through their activation of TFEB (25,64,65).…”
Section: Discussionmentioning
confidence: 99%
“…With the UPR response also driving regulation of TFEB, an acknowledged master regulator of autophagy and lysosomal biogenesis (64), CsA may hereby induce a blockade in autophagic flux and cause the selective lysosomal disorder that was not observed in Tac. Notably, mTOR inhibitors, commonly employed in combination with CNI, may have a beneficial effect herein through their activation of TFEB (25,64,65). Stimulated Arl8b expression standing for enhanced lysosomal exocytosis, which we observed in the proximal tubule of the CsA group, supported the lysosomal issue (66).…”
Section: Discussionmentioning
confidence: 99%
“…The nuclear localization of TFEB induced by starvation is different from the nuclear TFEB mediated by Wnt signaling. 95 …”
Section: Tfeb Signaling Pathwaysmentioning
confidence: 99%