Tetrazolo[1,5-<i>a</i>]pyrimidine-based metal(II) complexes as therapeutic agents: DNA interaction, targeting topoisomerase I and cyclin-dependent kinase studies

Haleel, Azees Khan; Mahendiran, Dharmasivam; Rafi, Ummer Muhammed; Veena, V.; Shobana, Shanmugam; Rahiman, A. Kalilur

doi:10.1080/24701556.2019.1571514

Cited by 9 publications

(6 citation statements)

References 46 publications

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“…Tetrazolo[1,5- a ]pyrimidine-based Cu(II) complexes 11 have a square planar geometry, and despite their high capability to inhibit Top1, interact with CDK for 11 [ 86 ] and VEGF receptors for an analog of 11 [ 87 ]. Binuclear Cu(II) dipeptide piperazine-bridged complex 12 recognizes specific sequences in the DNA, oxidatively cleaves DNA, and displays superoxide dismutase (SOD) activity [ 88 ].…”

Section: Copper Complexes As Topoisomerases Inhibitorsmentioning

confidence: 99%

“…Multiple stress factors ranging from various cell damages, ATP levels, and specific pathways (e.g., caspases) determine the type of cell death [ 157 ]. Most Top1 CuC inhibitors that interact with DNA [ 70 , 76 , 79 , 86 , 87 , 90 ], Top1 poison [ 89 ], Top2α CuC poison [ 109 ], or dual Top1/Top2 inhibitor [ 113 ] trigger apoptotic programmed cell death. Genetic damages and oxidative stress activate an intrinsic mitochondrial response [ 158 ].…”

Section: Programmed Cell Death Engaged By Copper Complexes and Topmentioning

confidence: 99%

“…CuC dual Top inhibitors display a high antiproliferative activity. Particularly, some CuC and non-CuC are dual inhibitors of Top1 and superoxide dismutase agonist [ 88 , 207 , 208 ] or Cdk receptor, like VEGF inhibitors, involved in cancer cells proliferation [ 86 , 87 , 209 , 210 ] ( Figure 5 B). Another strategy to improve therapies is the association of a CuC with a TDP1/2 (tyrosyl-DNA-phosphodiesterase 1/2) inhibitor.…”

Section: Future Strategies For Copper Complexes As Top Inhibitors mentioning

confidence: 99%

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Copper Complexes as Anticancer Agents Targeting Topoisomerases I and II

Molinaro

Martoriati

Pélinski

et al. 2020

Cancers

119

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Organometallics, such as copper compounds, are cancer chemotherapeutics used alone or in combination with other drugs. One small group of copper complexes exerts an effective inhibitory action on topoisomerases, which participate in the regulation of DNA topology. Copper complexes inhibitors of topoisomerases 1 and 2 work by different molecular mechanisms, analyzed herein. They allow genesis of DNA breaks after the formation of a ternary complex, or act in a catalytic mode, often display DNA intercalative properties and ROS production, and sometimes display dual effects. These amplified actions have repercussions on the cell cycle checkpoints and death effectors. Copper complexes of topoisomerase inhibitors are analyzed in a broader synthetic view and in the context of cancer cell mutations. Finally, new emerging treatment aspects are depicted to encourage the expansion of this family of highly active anticancer drugs and to expend their use in clinical trials and future cancer therapy.

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Section: Copper Complexes As Topoisomerases Inhibitorsmentioning

confidence: 99%

Section: Programmed Cell Death Engaged By Copper Complexes and Topmentioning

confidence: 99%

Section: Future Strategies For Copper Complexes As Top Inhibitors mentioning

confidence: 99%

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Copper Complexes as Anticancer Agents Targeting Topoisomerases I and II

Molinaro

Martoriati

Pélinski

et al. 2020

Cancers

119

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“…Furthermore, the complexes also inhibit topoisomerase I, and interact with cyclin-dependent kinase receptors. 119 The derivatives of biologically active 5,7-diaryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine derivatives 14 were synthesized in excellent yields by Ghorbani-Vaghei and coworkers using an LDH@TUSA@Ni nanocomposite approach based on the Biginelli reaction (Scheme 27). A one-pot, three-component reaction was characterized in this study, where 5-aminotetrazole (1), benzaldehydes 2, and substituted acetophenone derivatives 13 were reacted using LDH@TUSA@Ni nanocomposite catalyst in DMF at 80 °C.…”

Section: Review Synthesismentioning

confidence: 99%

Recent Advances in the Multicomponent Synthesis of Heterocycles Using 5-Aminotetrazole

Javahershenas,

Makarem,

Mei

et al. 2024

Synthesis

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The unique reactivity and beneficial features of the 5-aminotetrazole synthon (1H-tetrazol-5-amine) have made it a versatile and effective building block in the synthesis of heterocyclic compounds. In addition, several drugs containing this scaffold with a wide array of biological properties have been already introduced. Heterocyclic structures are the backbone of many biologically active and industrially important compounds. 5-Aminotetrazole is one of the favored synthons used in the preparation of heterocycle-bearing compounds, especially in multicomponent synthesis. This review highlights a comprehensive overview of the emerging applications of 5-aminotetrazole as a key component in the synthesis of heterocyclic frameworks through multicomponent reactions, reported between 2017 and July 2023.1 Introduction2 5-Aminotetrazole3 Tetrazolopyrimidine Compounds4 Spiro Compounds5 Miscellaneous6 Conclusion

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“…It was well known that some co-ordination compounds may inhibit cancer cell multiplication due to binding and damage to cancer DNA 2,4,14 . It was requisite en route for pattern metallic multiplexes by way of a reduced amount of lethal, target-peculiar as well as spending non-covalent binding modus in the direction of DNA 15 . Conflicting intercalators, groove binders inevitability partake springy structures 16 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral Characterization, Computational Revisions, Toxicology Studies In Addition To Biotic Studies of O-Phenylenediamine Based Schiff Base and Its Transition Metal Complexes

Indra¹,

Xavier²,

Harinathan³

2020

AJPTR

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E)-2-(1-((2-aminophenyl)imino)ethyl)phenol (APIEP) was charity in place of a ligand in lieu of the synthesis of a succession of metallic multiplexes, wherever the metals were Ni(II), Fe(III) and Zn(II). The structural sorts of the ligand in addition to the contrived multiplexes remained characterized by means of numerous spectral as well as diagnostic practices. FT-IR spectra exhibited that the liberty ligand APIEP accomplishes by means of tridentate with hydroxyl, amine and imine moiety were co-ordination sites to all the metal ions. The FT-IR stretching frequency for the above co-ordination sites were varied after co-ordination with Ni(II), Fe(III) then Zn(II) metallic salts. The metallic complexes exhibits octahedral geometry, it was confirmed by spectral techniques. Natal activities of the ligand APIEP voguish accumulation en route on behalf of its multiplexes have remained verified against anti-oxidant and anti-microbial strains. All the metallic multiplexes partake superior biotic doings than the free APIEP. The computational analysis like biological activity prediction, cell line cytotoxicity, acute rate toxicity, environmental toxicity and docking of the samples were done with online software and commercial docking software.

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Tetrazolo[1,5-a]pyrimidine-based metal(II) complexes as therapeutic agents: DNA interaction, targeting topoisomerase I and cyclin-dependent kinase studies

Cited by 9 publications

References 46 publications

Copper Complexes as Anticancer Agents Targeting Topoisomerases I and II

Copper Complexes as Anticancer Agents Targeting Topoisomerases I and II

Recent Advances in the Multicomponent Synthesis of Heterocycles Using 5-Aminotetrazole

Synthesis, Spectral Characterization, Computational Revisions, Toxicology Studies In Addition To Biotic Studies of O-Phenylenediamine Based Schiff Base and Its Transition Metal Complexes

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