Tetrahydrocannabinol-attenuated abstinence and induced rotation in morphine-dependent rats: Possible involvement of dopamine

Hine, Bromfield; Friedman, Eitan; Torrelio, Marina; Gershon, Samuel

doi:10.1016/0028-3908(75)90128-8

Cited by 31 publications

(5 citation statements)

References 4 publications

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“…Notably, a reduction in the incidence of escape jumps, paw tremors, weight loss, and diarrhea were most commonly reported in rodents (see Table 1 for original references). Exceptions to the reductions in withdrawal occurred only when the agonist (Δ 9 THC) was administered chronically during the development of morphine dependence ( Cichewicz and Welch, 2003 ; Gerak and France, 2016 ), when rats were made acutely dependent on morphine prior to withdrawal ( Hine et al, 1975b ), or when the cannabinoid tested, cannabidiol, was not a CB 1 receptor agonist ( Hine et al, 1975d , e ; Chesher and Jackson, 1985 ).…”

Section: Cannabinoids On Opiate Withdrawalmentioning

confidence: 99%

Effect of Pharmacological Modulation of the Endocannabinoid System on Opiate Withdrawal: A Review of the Preclinical Animal Literature

Wills

Parker

2016

Front. Pharmacol.

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Over the years, animal studies have revealed a role for the endocannabinoid system in the regulation of multiple aspects of opiate addiction. The current review provides an overview of this literature in regards to opiate withdrawal. The opiate withdrawal syndrome, hypothesized to act as a negative reinforcer in mediating continued drug use, can be characterized by the emergence of spontaneous or precipitated aversive somatic and affective states following the termination of drug use. The behaviors measured to quantify somatic opiate withdrawal and the paradigms employed to assess affective opiate withdrawal (e.g., conditioned place aversion) in both acutely and chronically dependent animals are discussed in relation to the ability of the endocannabinoid system to modulate these behaviors. Additionally, the brain regions mediating somatic and affective opiate withdrawal are elucidated with respect to their modulation by the endocannabinoid system. Ultimately, a review of these findings reveals dissociations between the brain regions mediating somatic and affective opiate withdrawal, and the ability of cannabinoid type 1 (CB1) receptor agonism/antagonism to interfere with opiate withdrawal within different brain sub regions.

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Section: Cannabinoids On Opiate Withdrawalmentioning

confidence: 99%

Effect of Pharmacological Modulation of the Endocannabinoid System on Opiate Withdrawal: A Review of the Preclinical Animal Literature

Wills

Parker

2016

Front. Pharmacol.

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“…Similarly, cannabis induces aggressive behaviour in 6-hydroxydopamine (6-OHDA) pretreated rats (Musty et al, 1976) and in morphine-abstinent rats (Carlini & Gonzalez, 1972). Opiate (Gianutsos, Hynes, Puri, Drawbaugh & Lal, 1974) and 6-OHDA (Barnes, Cann, Karczmar, Kindel & Longo, 1973) (Kramer & Ben David, 1974) and induction of turning behaviour (Waters & Glick, 1973;Hine, Friedman, Torrelio & Gershon, 1975) serve as examples. A question that may be asked is, if the changes that were observed in response to nomifensine and A9-THC or marihuana are due to REM sleep-deprivation per se or to the stress derived from the deprivation procedure.…”

Section: Discussionmentioning

confidence: 99%

“…Other data in the literature can be found that are indicative of possible dopaminergic actions of cannabis. A9-THC-induced inhibition of prolactin secretion (Kramer & Ben David, 1974) and induction of turning behaviour (Waters & Glick, 1973;Hine, Friedman, Torrelio & Gershon, 1975) serve as examples.…”

Section: Discussionmentioning

confidence: 99%

Cannabis, Catecholamines, Rapid Eye Movement Sleep and Aggressive Behaviour

Carlini

Lindsey

Tufik

1977

British J Pharmacology

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1Previous work from our laboratory has shown that cannabis induces aggressive behaviour in rats that have been deprived of rapid eye movement (REM) sleep. It was suggested that this effect was related to brain catecholamines, with dopamine playing an agonist role and noradrenaline an inhibitory one. The present paper describes new experiments dealing with this subject. 2 Previous REM sleep-deprivation enhanced both A9-tetrahydrocannabinol (THC)-induced hypothermia and nomifensine effects on aggressive behaviour. 3 A marihuana extract decreased brain dopamine turnover in REM sleep-deprived rats, an effect not observed in non-deprived rats. Noradrenaline metabolism was not altered. 4 Fighting behaviour was elicited in REM sleep-deprived rats treated with 4 different dopamine-,6-hydroxylase inhibitors. 5 Apomorphine, nomifensine and A9-THC administered to non-deprived rats pretreated with bis(4-methyl-l-homopiperanzinyl-thiocarbonyl) disulphide (Fla-63), induced fighting behaviour. 6 Nomifensine and apomorphine induced fighting in non-deprived rats pretreated with A9-THC. 7 Clonidine inhibited the fighting elicited in REM sleep-deprived rats by either A9-THC or 8 The data are discussed in terms of the influence of REM sleep-deprivation (or the stress associated with deprivation) on the response to dopaminergic drugs and cannabis. Taken together they emphasize the participation of brain dopamine and noradrenaline systems in the aggressive behaviour studied.

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“…For example, both CB 1 and mu opioid receptor activation increase dopamine release in the nucleus accumbens (an effect observed for most abused drugs) and the effect of both can be blocked by infusion of naloxone (Tanda et al, 1997). Other studies have demonstrated that exogenous ∆ 9 -THC decreases signs of opioid withdrawal in morphine-dependent mice and rats (Hine et al, 1975a, 1975b; Bhargava, 1976,; Lichtman et al, 2001; Cichewicz and Welch, 2003; Gamage et al, 2015), and conversely, CB 1 antagonists precipitate opioid withdrawal (Scavone et al, 2013). …”

Section: Introductionmentioning

confidence: 95%

Opioid withdrawal suppression efficacy of oral dronabinol in opioid dependent humans

Lofwall

Babalonis

Nuzzo

et al. 2016

Drug and Alcohol Dependence

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Background The cannabinoid (CB) system is a rational novel target for treating opioid dependence, a significant public health problem around the world. This proof-of-concept study examined the potential efficacy of a CB1 receptor partial agonist, dronabinol, in relieving signs and symptoms of opioid withdrawal. Methods Twelve opioid dependent adults participated in this 5-week, inpatient, double-blind, randomized, placebo-controlled study. Volunteers were maintained on double-blind oxycodone (30mg oral, four times/day) and participated in a training session followed by 7 experimental sessions, each testing a single oral test dose (placebo, oxycodone 30 and 60mg, dronabinol 5, 10, 20, and 30mg [decreased from 40mg]). Placebo was substituted for oxycodone maintenance doses for 21 hours before each session in order to produce measurable opioid withdrawal. Outcomes included observer- and participant-ratings of opioid agonist, opioid withdrawal and psychomotor/cognitive performance. Results Oxycodone produced prototypic opioid agonist effects (i.e., suppressing withdrawal and increasing subjective effects indicative of abuse liability). Dronabinol 5 and 10mg produced effects most similar to placebo, while the 20 and 30mg doses produced modest signals of withdrawal suppression that were accompanied by dose-related increases in high, sedation, bad effects, feelings of heart racing, and tachycardia. Dronabinol was not liked more than placebo, showed some impairment in cognitive performance, and was identified as marijuana with increasing dose. Conclusion CB1 receptor activation is a reasonable strategy to pursue for the treatment of opioid withdrawal; however, dronabinol is not a likely candidate given its modest withdrawal suppression effects of limited duration and previously reported tachycardia during opioid withdrawal.

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Tetrahydrocannabinol-attenuated abstinence and induced rotation in morphine-dependent rats: Possible involvement of dopamine

Cited by 31 publications

References 4 publications

Effect of Pharmacological Modulation of the Endocannabinoid System on Opiate Withdrawal: A Review of the Preclinical Animal Literature

Effect of Pharmacological Modulation of the Endocannabinoid System on Opiate Withdrawal: A Review of the Preclinical Animal Literature

Cannabis, Catecholamines, Rapid Eye Movement Sleep and Aggressive Behaviour

Opioid withdrawal suppression efficacy of oral dronabinol in opioid dependent humans

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