Tetrahedral DNA nanostructures for effective treatment of cancer: advances and prospects

Yan, Jianqin; Zhan, Xiaowei; Zhang, Zhuangzhuang; Chen, Keqi; Wang, Maolong; Sun, Yong; He, Bin; Liang, Yan

doi:10.1186/s12951-021-01164-0

Cited by 58 publications

(36 citation statements)

References 122 publications

(129 reference statements)

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“… 9 – 12 Subsequently, these generated ROS like ·OH can attack and destroy bacterial membrane, DNA, and protein at the acidic infectious site, further resulting in bacterial inactivation. 13 , 14 Notably, compared with antibiotics, the bactericidal strategy based on the production of reactive oxygen species (ROS) can significantly avoid the occurrence of drug resistance. 15 , 16 Currently, various nanozymes including carbon and metal oxide/chalcogenide nanomaterials, have been successfully employed as antibacterial agents.…”

Section: Introductionmentioning

confidence: 99%

POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy

Cao

Zhang

Yang

et al. 2022

Sig Transduct Target Ther

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The current feasibility of nanocatalysts in clinical anti-infection therapy, especially for drug-resistant bacteria infection is extremely restrained because of the insufficient reactive oxygen generation. Herein, a novel Ag/Bi2MoO6 (Ag/BMO) nanozyme optimized by charge separation engineering with photoactivated sustainable peroxidase-mimicking activities and NIR-II photodynamic performance was synthesized by solvothermal reaction and photoreduction. The Ag/BMO nanozyme held satisfactory bactericidal performance against methicillin-resistant Staphylococcus aureus (MRSA) (~99.9%). The excellent antibacterial performance of Ag/BMO NPs was ascribed to the corporation of peroxidase-like activity, NIR-II photodynamic behavior, and acidity-enhanced release of Ag+. As revealed by theoretical calculations, the introduction of Ag to BMO made it easier to separate photo-triggered electron-hole pairs for ROS production. And the conduction and valence band potentials of Ag/BMO NPs were favorable for the reduction of O2 to ·O2−. Under 1064 nm laser irradiation, the electron transfer to BMO was beneficial to the reversible change of Mo5+/Mo6+, further improving the peroxidase-like catalytic activity and NIR-II photodynamic performance based on the Russell mechanism. In vivo, the Ag/BMO NPs exhibited promising therapeutic effects towards MRSA-infected wounds. This study enriches the nanozyme research and proves that nanozymes can be rationally optimized by charge separation engineering strategy.

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Section: Introductionmentioning

confidence: 99%

POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy

Cao

Zhang

Yang

et al. 2022

Sig Transduct Target Ther

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“…However, the aimless distribution of chemodrugs in the body, in other words, the nonspecific target to the tumor site, will cause underdose but induce systemic toxicity and side effects on healthy cells (Yan et al, 2020). To deliver targeted chemotherapeutic drugs to the tumor site, drug delivery systems (DDSs) based on organic, inorganic, or hybrid DDSs as trucks would enhance the drug contents within tumors (Yan et al, 2021). To function as high‐efficiency DDSs, the “five features principle” should be satisfied, including “ long circulation ”, “ enhanced tumor accumulation ”, “ deep tumor penetration ”, “ efficient cellular internalization ”, and “ drug release ” (Yong et al, 2020).…”

Section: Cu‐based Nms For Combined Cancer Therapymentioning

confidence: 99%

Copper‐based nanomaterials for cancer theranostics

Zhong

Wang

Qian

et al. 2022

WIREs Nanomed Nanobiotechnol

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Copper‐based nanomaterials (Cu‐based NMs) with favorable biocompatibility and unique properties have attracted the attention of many biomedical researchers. Cu‐based NMs are one of the most widely studied materials in cancer treatment. In recent years, great progress has been made in the field of biomedicine, especially in the treatment and diagnosis of tumors. This review begins with the classification of Cu‐based NMs and the recent synthetic strategies of Cu‐based NMs. Then, according to the abundant and special properties of Cu‐based NMs, their application in biomedicine is summarized in detail. For biomedical imaging, such as photoacoustic imaging, positron emission tomography imaging, and multimodal imaging based on Cu‐based NMs are summarized, as well as strategies to improve the diagnostic effectiveness. Moreover, a series of unique structures and functions as well as the underlying property activity relationship of Cu‐based NMs were shown to highlight their promising therapeutic performance. Cu‐based NMs have been widely used in monotherapies, such as photothermal therapy (PTT) and chemodynamic therapy (CDT). Moreover, the sophisticated design in composition, structure, and surface fabrication of Cu‐based NMs can endow these NMs with more modalities in cancer diagnosis and therapy. To further improve the efficiency of cancer treatment, combined therapy based on Cu‐based NMs was introduced in detail. Finally, the challenges, critical factors, and future prospects for the clinical translation of Cu‐based NMs as multifunctional theranostic agents were also considered and discussed. The aim of this review is to provide a better understanding and key consideration for the rational design of this increasingly important new paradigm of Cu‐based NMs as theranostic agents. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools > In Vivo Nanodiagnostics and Imaging

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“…The DNA tetrahedron described here has been used often in biological applications including biosensing and drug delivery, necessitating purification of these DNA nanostructures (Copp et al., 2021; Dou et al., 2022; Xie et al., 2017; Yan et al., 2021). The DNA tetrahedron has been previously constructed and thoroughly characterized by several groups.…”

Section: Commentarymentioning

confidence: 99%

Purification of Self‐Assembled DNA Tetrahedra Using Gel Electrophoresis

et al. 2022

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DNA nanostructures have found applications in a variety of fields such as biosensing, drug delivery, cellular imaging, and computation. Several of these applications require purification of the DNA nanostructures once they are assembled. Gel electrophoresis–based purification of DNA nanostructures is one of the methods used for this purpose. Here, we describe a step‐by‐step protocol for a gel‐based method to purify self‐assembled DNA tetrahedra. With further optimization, this method could also be adapted for other DNA nanostructures. © 2022 Wiley Periodicals LLC. Basic Protocol: Purification of self‐assembled DNA tetrahedra

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Tetrahedral DNA nanostructures for effective treatment of cancer: advances and prospects

Cited by 58 publications

References 122 publications

POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy

POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy

Copper‐based nanomaterials for cancer theranostics

Purification of Self‐Assembled DNA Tetrahedra Using Gel Electrophoresis

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