2018
DOI: 10.1021/acsami.8b16518
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Abstract: The problem of tissue vascularization is one of the obstacles that currently restricts the application of tissue engineering products to the clinic. Achieving tissue vascularization and providing adequate nutrients for tissues are an urgent problem to build complex and effective tissue-engineered tissues and organs. Therefore, the aim of this study was to investigate the effect of tetrahedral DNA nanostructures (TDNs), a novel and biocompatible nanomaterial, on angiogenesis. The results showed that TDNs can en… Show more

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Cited by 45 publications
(53 citation statements)
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“…Tetrahedral framework nucleic acids (tFNAs) are synthesized by four isometric single‐stranded DNAs through a simple, rapid, and reliable process, which have been identified as 3D DNA nanostructures with a stable structure and superior mechanical properties . Many biological functions can be affected after tFNAs are transported into cells, including osteogenic differentiation, nerve tissue regeneration, anti‐inflammatory, and antioxidant effects . In addition, tFNAs can be easily formulated as eye drops, which can be very convenient for experimental research and clinical use in the future.…”
Section: Introductionmentioning
confidence: 99%
“…Tetrahedral framework nucleic acids (tFNAs) are synthesized by four isometric single‐stranded DNAs through a simple, rapid, and reliable process, which have been identified as 3D DNA nanostructures with a stable structure and superior mechanical properties . Many biological functions can be affected after tFNAs are transported into cells, including osteogenic differentiation, nerve tissue regeneration, anti‐inflammatory, and antioxidant effects . In addition, tFNAs can be easily formulated as eye drops, which can be very convenient for experimental research and clinical use in the future.…”
Section: Introductionmentioning
confidence: 99%
“…(1) In vitro study (2) In vivo wound model exposed to Escherichia coli [40] PLLA electrospun fibrous membranes (1) In vitro study (2) In vivo diabetic wound model [35] Cu 2 S Nanoflowers (1) In vitro study (2) In vivo diabetic wound model [36] CaCuSi 4 O 10 nanoparticles coated on the surface of Poly (ε-caprolactone) and Poly (D, L-lactic acid) (PP) fibers (1) In vivo diabetic wound model cancer surgerycaused wounds in tumor-bearing mice [37] Nerve tissue repair rGO In vivo spinal cord hemisection model [48] PLGA nanoparticles In vivo spinal cord hemisection model [45] Ischemia reperfusion GO (1) In vitro study (2) In vivo myocardial infarction model [49,50] Tetrahedral DNA nanostructures In vitro study [137] thus, the characteristics and slow-release structure of its specific ions are still unclear. An ideal scaffold for bone tissue engineering should promote vascularized bone formation.…”
Section: Nanomaterials Type Of Angiogenesis Assays Referencesmentioning
confidence: 99%
“…(1) Nanotopology combines aligned electrospun fibers and nanopores can serve as a signaling mechanism to control cell growth and differentiation (2) Avoiding the detachment of nanoparticles (3) Delivery system [35] Tetrahedral DNA Triangular nanoparticles, formed by four ss-DNAs fragments [137] (1) Promote the proliferation, migration and tube formation of ECs (2) Increase the expression of VEGFA, VEGFR2…”
Section: Dimensionsmentioning
confidence: 99%
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