Tetrahedral DNA Enhanced Antibacterial Effect of Lysozyme
Yingqi Zhang,
Wei Feng,
Wenke Zhang
Abstract:Lysozyme (Lys) is a potential candidate to address the issue of drug-resistant bacteria with conventional antibiotics. However, its weak killing effect on Gram-negative bacteria hinders its prospect for clinical application. To solve this problem, we modified lysozyme using a tetrahedral framework nucleic acid (TDN) to construct its complex (TDN-Lys). With the help of TDN, lysozyme showed a great bactericidal effect against both drug-resistant bacteria, MRSA, and Gram-negative bacteria, E. coli O157:H7. Morph… Show more
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