Tetracycline and Epidermolysis Bullosa Simplex

Epidermolysis bullosa – a group of skin diseases with different causes but commonalities in gene expression

“…Other cutaneous features include milia, nail dystrophy or absence and scarring. Disease severity depends on the type of mutation and the precise location of the affected protein .…”

“…Generally, EB is divided into four major groups: epidermolytic EB or EB simplex (EBS), lucidolytic or junctional EB (JEB), dermolytic or dystrophic EB (DEB) and Kindler syndrome . For EBS, JEB and DEB, this classification reflects the level on which the skin split takes places and hence the level of blister formation.…”

“…Epidermolysis Bullosa Simplex is characterized by blistering within the basal keratinocytes and is divided into ‘EBS, localized’ and ‘EBS‐generalized other’ (formerly the Dowling Meara, Weber Cockayne and Koebner subtype) . These subtypes are caused by mutations in KRT5 or KRT14, encoding keratin 5 and keratin 14 .…”

“…There is a full‐length and a truncated form of plectin. While the full‐length form is reduced or absent in EBS‐MD , truncated plectin is expressed . The ratio depends on the cell type: in fibroblasts and keratinocytes, full‐length plectin levels exceed those of the truncated isoform.…”

“…GABEB (generalized benign epidermolysis bullosa) is a subtype of junctional epidermolysis bullosa. JEB is divided into two main subtypes: ‘Herlitz’ and ‘others’ . The subtype investigated in this study, formerly known as GABEB, counts among JEB non‐Herlitz, generalized (JEB‐nH gen).…”