Tetracycline and Chloramphenicol Studies on Rabbit and Human Eyes

Pharmacokinetics of amikacin and chloramphenicol in the aqueous humor of rabbits

“…While the terminal aqueous humor and serum levels of chloramphenicol were equal, this was also true for the peripheral compartment. Consistently, previous studies using data pooled from different subjects show excellent penetration for chloramphenicol but not for amikacin into the aqueous humor (2,8,9,17,20).…”

“…In these experiments, we compared amikacin and chloramphenicol since they have different physicochemical properties which are known to influence penetration of blood-brain and blood-aqueous humor barriers. Chloramphenicol, which is both lipophilic and uncharged (12), has better penetration of the blood-aqueous humor barrier (2,9,17,20) than does amikacin (8,17). Figure 3A and B show the mean drug levels in serum and aqueous humor of five rabbits given amikacin intravenously.…”

Pharmacokinetics of amikacin and chloramphenicol in the aqueous humor of rabbits

“…While the terminal aqueous humor and serum levels of chloramphenicol were equal, this was also true for the peripheral compartment. Consistently, previous studies using data pooled from different subjects show excellent penetration for chloramphenicol but not for amikacin into the aqueous humor (2,8,9,17,20).…”

“…In these experiments, we compared amikacin and chloramphenicol since they have different physicochemical properties which are known to influence penetration of blood-brain and blood-aqueous humor barriers. Chloramphenicol, which is both lipophilic and uncharged (12), has better penetration of the blood-aqueous humor barrier (2,9,17,20) than does amikacin (8,17). Figure 3A and B show the mean drug levels in serum and aqueous humor of five rabbits given amikacin intravenously.…”

Doxycycline in the Management of Pseudomonas Corneal Melting

“…37 Application of topical tetracycline has been shown to have poor penetration through an intact cornea. 38 In the United Kingdom, topical tetracycline is no longer commercially available. However, systemic administration overcomes problems with corneal toxicity reactions that may be associated with topical use.…”

“…39 In a study of tetracycline levels in rabbit and human eyes, orally and intravenously administered levels had detectable levels in the aqueous, but topical administration showed little penetration through an intact cornea into the aqueous. 38 Another study showed that although tetracycline can be detected in the aqueous after systemic administration, vitreous levels were negative. With respect to the ratio of aqueous-to-plasma concentration, tetracycline can penetrate the aqueous at a level approximately 20% to 25% of the plasma concentration.…”

The Penetration of Vibramycin (Doxycycline) in Human Aqueous Humor

“…Sometimes the values are different for one substance if administered by various routes [1]. The typical example is chloramphenicol; its penetration into the aqueous humor has been studied by several authors [1,2,3,4,5,6,7,26,27], all of whom have found different rates of penetration. We would like to present our paper dealing with the penetration of a new tetracycline, doxycycline, currently used in general medicine and ophthalmology.…”

Pharmacokinetics of amikacin and chloramphenicol in the aqueous humor of rabbits

“…While the terminal aqueous humor and serum levels of chloramphenicol were equal, this was also true for the peripheral compartment. Consistently, previous studies using data pooled from different subjects show excellent penetration for chloramphenicol but not for amikacin into the aqueous humor (2,8,9,17,20).…”

“…In these experiments, we compared amikacin and chloramphenicol since they have different physicochemical properties which are known to influence penetration of blood-brain and blood-aqueous humor barriers. Chloramphenicol, which is both lipophilic and uncharged (12), has better penetration of the blood-aqueous humor barrier (2,9,17,20) than does amikacin (8,17). Figure 3A and B show the mean drug levels in serum and aqueous humor of five rabbits given amikacin intravenously.…”

Doxycycline in the Management of Pseudomonas Corneal Melting

“…37 Application of topical tetracycline has been shown to have poor penetration through an intact cornea. 38 In the United Kingdom, topical tetracycline is no longer commercially available. However, systemic administration overcomes problems with corneal toxicity reactions that may be associated with topical use.…”

“…39 In a study of tetracycline levels in rabbit and human eyes, orally and intravenously administered levels had detectable levels in the aqueous, but topical administration showed little penetration through an intact cornea into the aqueous. 38 Another study showed that although tetracycline can be detected in the aqueous after systemic administration, vitreous levels were negative. With respect to the ratio of aqueous-to-plasma concentration, tetracycline can penetrate the aqueous at a level approximately 20% to 25% of the plasma concentration.…”

The Penetration of Vibramycin (Doxycycline) in Human Aqueous Humor

“…Sometimes the values are different for one substance if administered by various routes [1]. The typical example is chloramphenicol; its penetration into the aqueous humor has been studied by several authors [1,2,3,4,5,6,7,26,27], all of whom have found different rates of penetration. We would like to present our paper dealing with the penetration of a new tetracycline, doxycycline, currently used in general medicine and ophthalmology.…”

Pharmacokinetics of amikacin and chloramphenicol in the aqueous humor of rabbits

“…While the terminal aqueous humor and serum levels of chloramphenicol were equal, this was also true for the peripheral compartment. Consistently, previous studies using data pooled from different subjects show excellent penetration for chloramphenicol but not for amikacin into the aqueous humor (2,8,9,17,20).…”

“…In these experiments, we compared amikacin and chloramphenicol since they have different physicochemical properties which are known to influence penetration of blood-brain and blood-aqueous humor barriers. Chloramphenicol, which is both lipophilic and uncharged (12), has better penetration of the blood-aqueous humor barrier (2,9,17,20) than does amikacin (8,17). Figure 3A and B show the mean drug levels in serum and aqueous humor of five rabbits given amikacin intravenously.…”

Doxycycline in the Management of Pseudomonas Corneal Melting

“…37 Application of topical tetracycline has been shown to have poor penetration through an intact cornea. 38 In the United Kingdom, topical tetracycline is no longer commercially available. However, systemic administration overcomes problems with corneal toxicity reactions that may be associated with topical use.…”

“…39 In a study of tetracycline levels in rabbit and human eyes, orally and intravenously administered levels had detectable levels in the aqueous, but topical administration showed little penetration through an intact cornea into the aqueous. 38 Another study showed that although tetracycline can be detected in the aqueous after systemic administration, vitreous levels were negative. With respect to the ratio of aqueous-to-plasma concentration, tetracycline can penetrate the aqueous at a level approximately 20% to 25% of the plasma concentration.…”

The Penetration of Vibramycin (Doxycycline) in Human Aqueous Humor

“…Sometimes the values are different for one substance if administered by various routes [1]. The typical example is chloramphenicol; its penetration into the aqueous humor has been studied by several authors [1,2,3,4,5,6,7,26,27], all of whom have found different rates of penetration. We would like to present our paper dealing with the penetration of a new tetracycline, doxycycline, currently used in general medicine and ophthalmology.…”