2016
DOI: 10.18632/aging.101095
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Abstract: Chronological aging of the yeast Saccharomyces cerevisiae is attributed to multi-faceted traits especially those involving genome instability, and has been considered to be an aging model for post-mitotic cells in higher organisms. Telomeres are the physical ends of eukaryotic chromosomes, and are essential for genome integrity and stability. It remains elusive whether dysregulated telomerase activity affects chronological aging. We employed the CDC13-EST2 fusion gene, which tethers telomerase to telomeres, to… Show more

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Cited by 8 publications
(15 citation statements)
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References 72 publications
(103 reference statements)
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“…Chronological lifespan is usually defined as the time period when cells remain viable at stationary phase (G 0 phase) [33]. The budding yeast post-mitotic cell ageing usually undergoes for 1–2 months of survival and has been widely used in ageing research [26,35,36,37,38,39,40,41,42]. It is believed that evolutionarily conserved key molecules in the polarization processes from yeast budding and mating to metazoan neuronal outgrowth and spinogenesis are homologous, potentially making the yeast chronological ageing process as a useful model for the non-dividing human cell ageing research [43,44,45,46,47,48,49].…”
Section: Cell Chronological Ageingmentioning
confidence: 99%
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“…Chronological lifespan is usually defined as the time period when cells remain viable at stationary phase (G 0 phase) [33]. The budding yeast post-mitotic cell ageing usually undergoes for 1–2 months of survival and has been widely used in ageing research [26,35,36,37,38,39,40,41,42]. It is believed that evolutionarily conserved key molecules in the polarization processes from yeast budding and mating to metazoan neuronal outgrowth and spinogenesis are homologous, potentially making the yeast chronological ageing process as a useful model for the non-dividing human cell ageing research [43,44,45,46,47,48,49].…”
Section: Cell Chronological Ageingmentioning
confidence: 99%
“…More recently, no effect of long telomeres on vegetative cell division, meiosis or in cell chronological lifespan is observed in the yeast [57]. During chronological ageing, longer telomeres remain stable albeit without affecting chronological lifespan [42]. These strains with 2–4 folds longer telomeres do not carry any plasmids or gene deletions, potentially applicable to assess the relationship between overlong telomeres and chronological lifespan [42].…”
Section: Roles Of Telomere Length In Cell Senescence Replicative mentioning
confidence: 99%
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“…One copy of RIF1 was deleted in BY4743 by a pRS306-rif1Δ cassette as descried previously (Liu et al, 2016;Wu et al, 2017). Rif1-5UTR-F & T7 and Rif1-orf-F& Rif1-orf-R were used to confirm RIF1 deletion.…”
Section: Yeast Strains Plasmids and Primersmentioning
confidence: 99%