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Cited by 12 publications
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References 18 publications
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“…Breakdown or structural damage to capillary walls resulting from disease may provide one situation in which vascular cells experience altered loading (33); exercise may also provide this type of stimulus, and previous studies have noted alterations in capillary densities with exercise (34). Previously calculated strain levels in capillary walls during systolic contraction and stable diastolic arrest range between 0 to 22% (30,35), supporting the physiologic relevance of the 7% strain amplitude used in of our studies (29). Other investigations have used similar strain levels to study the effects of mechanical cue effects on ECs in vitro, specifically in the context of angiogenesis (36)(37)(38).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Breakdown or structural damage to capillary walls resulting from disease may provide one situation in which vascular cells experience altered loading (33); exercise may also provide this type of stimulus, and previous studies have noted alterations in capillary densities with exercise (34). Previously calculated strain levels in capillary walls during systolic contraction and stable diastolic arrest range between 0 to 22% (30,35), supporting the physiologic relevance of the 7% strain amplitude used in of our studies (29). Other investigations have used similar strain levels to study the effects of mechanical cue effects on ECs in vitro, specifically in the context of angiogenesis (36)(37)(38).…”
Section: Discussionmentioning
confidence: 99%
“…In vitro sprouting was used as a model for the initial stages of angiogenesis, as previously described (25)(26)(27)(28). Vascular cell cultures were exposed to cyclic tensile strain with an amplitude of 7%, representative of that experienced by vascular cells in large vessels, and also in the same range as previous calculations of capillary wall strain (29,30). Cyclic tensile strain was demonstrated to alter vascular cell phenotype and the secretion of Ang-2 and PDGF by EC.…”
mentioning
confidence: 99%
“…The extracellular collagen structure between cardiac muscle cells and the coronary vasculature, in particular the collagen struts, have been proposed to decrease the effect of cardiac contraction on the vasculature by preventing collapse of the capillaries in systole (2,46), and to increase interstitial pressure in diastole (312). It was also proposed that the collagen fibers affect the transmission of radial forces, which in turn play a role in the generation of intramyocardial pressure (40).…”
Section: A Theoretical Suggestionsmentioning
confidence: 99%
“…In a study of coronary capillaries it was concluded that tethering of these tubes to the surrounding myocytes prevents capillary collapse during systole of the heart [ 1 ], and this raises the question as to whether the very fine ”tethers” of collagen shown in Figure 1 perform a similar role in skeletal muscle? The issue of regulation of blood flow through the capillary tubes is another topic much in need of research.…”
Section: Discussionmentioning
confidence: 99%