Joshua Rees-Garbutt, Jake Rightmyer, Oliver Chalkley, Lucia Marucci, Claire Grierson
Numerous authors have pondered what the minimal gene set for life might be and many hypothetical minimal gene sets have been proposed, including at least 10 for Mycoplasma genitalium (M.genitalium) . None of these have been reported to be tested in-vivo or in-silico . In-vivo testing would be extremely difficult as M.genitalium is very difficult to grow in the laboratory and laborious to engineer. However, the M.genitalium whole-cell model provides the first opportunity to test them in-silico . We simulated t…
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