Testing of cigarette smoke inhalation for teratogenicity in rats

In Utero and Lactation Exposure of Rats to 1R4F Reference Cigarette Mainstream Smoke: Effect on Prenatal and Postnatal Development

“…The results of the present study indicate a smoke concentration-related decrease in average birth weight and confirm our earlier observations using this smoke-exposure design (Carmines et al, 2003). Our findings were consistent with other reports using less-characterized smoke-exposure situations where birth weight effects were noted (Bertolini et al, 1982;Magers et al, 1995;Peterson et al, 1981;Reckzeh et al, 1975;Reznik and Marquard, 1980;Schoeneck, 1941;Seller and Bnait, 1995;Wagner, 1972).…”

In Utero and Lactation Exposure of Rats to 1R4F Reference Cigarette Mainstream Smoke: Effect on Prenatal and Postnatal Development

“…The results of the present study indicate a smoke concentration-related decrease in average birth weight and confirm our earlier observations using this smoke-exposure design (Carmines et al, 2003). Our findings were consistent with other reports using less-characterized smoke-exposure situations where birth weight effects were noted (Bertolini et al, 1982;Magers et al, 1995;Peterson et al, 1981;Reckzeh et al, 1975;Reznik and Marquard, 1980;Schoeneck, 1941;Seller and Bnait, 1995;Wagner, 1972).…”

Evaluation of submarine atmospheres: effects of carbon monoxide, carbon dioxide and oxygen on general toxicology, neurobehavioral performance, reproduction and development in rats. II. Ninety-day study

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Smoking during pregnancy: Postnatal effects on arousal and attentional brain systems

“…Brain weights were not taken due to the need for rapid dissection of brain tissue required to generate viable slices. Previous studies showed doses of cigarette smoke tolerated by the pregnant rats were similar to those used here did not induce differences in fetal weight, length, or other teratological measures (Reczeh et al, 1975). However, recent studies in the mouse have shown that tobacco smoke produces a dose-related retardation in embryonic growth (Seller and Bnait, 1995).…”

In Utero and Lactation Exposure of Rats to 1R4F Reference Cigarette Mainstream Smoke: Effect on Prenatal and Postnatal Development

“…The results of the present study indicate a smoke concentration-related decrease in average birth weight and confirm our earlier observations using this smoke-exposure design (Carmines et al, 2003). Our findings were consistent with other reports using less-characterized smoke-exposure situations where birth weight effects were noted (Bertolini et al, 1982;Magers et al, 1995;Peterson et al, 1981;Reckzeh et al, 1975;Reznik and Marquard, 1980;Schoeneck, 1941;Seller and Bnait, 1995;Wagner, 1972).…”

Evaluation of submarine atmospheres: effects of carbon monoxide, carbon dioxide and oxygen on general toxicology, neurobehavioral performance, reproduction and development in rats. II. Ninety-day study

“……”

Smoking during pregnancy: Postnatal effects on arousal and attentional brain systems

“…Brain weights were not taken due to the need for rapid dissection of brain tissue required to generate viable slices. Previous studies showed doses of cigarette smoke tolerated by the pregnant rats were similar to those used here did not induce differences in fetal weight, length, or other teratological measures (Reczeh et al, 1975). However, recent studies in the mouse have shown that tobacco smoke produces a dose-related retardation in embryonic growth (Seller and Bnait, 1995).…”

In Utero and Lactation Exposure of Rats to 1R4F Reference Cigarette Mainstream Smoke: Effect on Prenatal and Postnatal Development

“…The results of the present study indicate a smoke concentration-related decrease in average birth weight and confirm our earlier observations using this smoke-exposure design (Carmines et al, 2003). Our findings were consistent with other reports using less-characterized smoke-exposure situations where birth weight effects were noted (Bertolini et al, 1982;Magers et al, 1995;Peterson et al, 1981;Reckzeh et al, 1975;Reznik and Marquard, 1980;Schoeneck, 1941;Seller and Bnait, 1995;Wagner, 1972).…”

Evaluation of submarine atmospheres: effects of carbon monoxide, carbon dioxide and oxygen on general toxicology, neurobehavioral performance, reproduction and development in rats. II. Ninety-day study

“……”

Smoking during pregnancy: Postnatal effects on arousal and attentional brain systems

“…Brain weights were not taken due to the need for rapid dissection of brain tissue required to generate viable slices. Previous studies showed doses of cigarette smoke tolerated by the pregnant rats were similar to those used here did not induce differences in fetal weight, length, or other teratological measures (Reczeh et al, 1975). However, recent studies in the mouse have shown that tobacco smoke produces a dose-related retardation in embryonic growth (Seller and Bnait, 1995).…”