Testicular tumors in the pediatric patient

Jarvis, Hannah; Cost, Nicholas G.; Saltzman, Amanda F.

doi:10.1016/j.sempedsurg.2021.151079

Cited by 9 publications

(15 citation statements)

References 32 publications

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“…TYST demonstrates a distinct distribution with the peak presenting at a median age of two years ( 8 , 12 ). Our study population exactly mirrors the distribution of disease described; the median age at diagnosis was 18 months, and 74.3% of the patients had a peak incidence between 0 and 2 years.…”

Section: Discussionmentioning

confidence: 99%

“…In total, 8.3% of patients were diagnosed with concomitant hydrocele/inguinal hernia, cryptorchidism, testicular epididymitis, testicular torsion and varicocele. These results showed that patients with the above diseases might be misdiagnosed, so careful physical examination and ultrasound might be conducive to the early detection of testicular tumor and timely treatment ( 12 ).…”

Section: Discussionmentioning

confidence: 99%

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Characteristics and outcomes of pediatric testicular yolk Sac tumor

Wang

et al. 2022

Front. Pediatr.

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PurposePediatric testicular yolk sac tumor is a rare malignant germ cell tumor and there is a lack of large clinical studies. The purpose of this study is to summarize the clinical characteristics of pediatric testicular yolk tumor and evaluate the prognostic factors.Materials and methodsThe medical records of children with testicular yolk sac tumor in one pediatric medical centre in China from January 2005 to January 2021 were retrospectively investigated. Data regarding clinical characteristics, treatment and prognosis were collected.ResultsA total of 109 patients with a median diagnosed age of 18 months (range 2–69) were included in this study; of them 100 were diagnosed as stage I, 6 as stage II and 3 as stage IV. All patients underwent radical orchiectomy, and 61 of them underwent postoperative chemotherapy. The mean follow-up time was 61.3 months (range 3–259), during that time, 8 patients experienced relapse. The five-year overall survival was 90.6% (95% CI 84.6%–96.7%). Univariate Cox regression analysis showed that disease stage, relapse, maximum tumor diameter, and alpha-fetoprotein returning to normal within 2 months postoperatively were risk factors for survival (HRs of 25.43, 26.43, 1.48 and 0.08, respectively, p < 0.05). Multivariate Cox regression analysis suggested that higher disease stage and relapse were independent adverse factors for survival (HRs of 148.30 and 94.58, respectively, p < 0.05).ConclusionsThe prognosis of pediatric testicular yolk sac tumor is generally excellent. A higher disease stage and the occurrence of relapse could predict a poor prognosis. The individualized management of children with testicular yolk sac tumor according to risk classification is feasible.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Characteristics and outcomes of pediatric testicular yolk Sac tumor

Wang

et al. 2022

Front. Pediatr.

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“…[21, 22] Testicles: brain, liver and bones. [5, 23, 24] Thyroids: brain, liver and bones. [25, 26, 27] Nasopharynx: lip/oral cavity and liver.…”

Section: Methodsmentioning

confidence: 99%

The role of Absorbing Markov Chains in childhood cancer

Margarit

Reale

Scagliotti

et al. 2022

Preprint

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Absorbing Markov Chains are an important mathematical tool used for different applications in science. On the other hand, cancer and its metastases in children have a significant impact on health due to their degree of lethality. Therefore, the aim of this work is to model the metastatic pathways of the main childhood cancers worldwide. The probabilities of generating metastases, from a primary site to secondary and tertiary sites, were characterized by constructing a directed graph and the associated transition matrix. In addition, the time of absorption and the probabilities of absorption by each absorbing state were calculated.

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“…Testicular yolk sac tumor (TYST) is a rare malignant germ cell tumor with an incidence of <1% (1). The disease is often accompanied by elevated serum alpha-fetoprotein (AFP) (1)(2)(3)(4). TYST accounts for 11-18% of germ cell tumors and 10-44% of non-seminoma germ cell tumors (4).…”

Section: Introductionmentioning

confidence: 99%

“…TYST accounts for 11–18% of germ cell tumors and 10–44% of non-seminoma germ cell tumors ( 4 ). Due to its high degree of malignancy, insidious onset and rapid progression, TYST seriously threatens the survival of patients ( 2 , 3 ). Surgical resection of the primary tumor is a key factor in treatment.…”

Section: Introductionmentioning

confidence: 99%

Develop and validate nomogram to predict cancer-specific survival for patients with testicular yolk sac tumors

Wang²,

Li³

et al. 2022

Front. Public Health

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PurposeTesticular yolk sac tumor (TYST) is a rare malignant germ cell tumor that mainly occurs in young men. Due to the low incidence of yolk sac tumors, there is a lack of prospective cohort studies with large samples. We aimed to develop a nomogram to predict cancer-specific survival (CSS) in patients with TYST.Materials and methodsPatient information was downloaded from the Surveillance, Epidemiology and End Results (SEER) database. We enrolled all patients with TYST from 2000 to 2018, and all patients were randomly divided into a training set and a validation set. Univariate and multivariate Cox proportional hazards regression models were used to identify independent risk factors for patients. We constructed a nomogram based on the multivariate Cox regression model to predict 1-, 3-, and 5-year CSS in patients with TYST. We used a series of validation methods to test the accuracy and reliability of the model, including the concordance index (C-index), calibration curve and the area under the receiver operating characteristic curve (AUC).Results619 patients with TYST were enrolled in the study. Univariate and multivariate Cox regression analysis showed that age, T stage, M stage and chemotherapy were independent risk factors for CSS. A nomogram was constructed to predict the patient's CSS. The C-index of the training set and the validation set were 0.901 (95%CI: 0.859–0.847) and 0.855 (95%CI: 0.865–0.845), respectively, indicating that the model had excellent discrimination. The AUC showed the same results. The calibration curve also indicated that the model had good accuracy.ConclusionsIn this study, we constructed the nomogram for the first time to predict the CSS of patients with TYST, which has good accuracy and reliability and can help doctors and patients make clinical decisions.

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Testicular tumors in the pediatric patient

Cited by 9 publications

References 32 publications

Characteristics and outcomes of pediatric testicular yolk Sac tumor

Characteristics and outcomes of pediatric testicular yolk Sac tumor

The role of Absorbing Markov Chains in childhood cancer

Develop and validate nomogram to predict cancer-specific survival for patients with testicular yolk sac tumors

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