Testicular Synthesis and Vitamin D Action

Hofer, Doris; Münzker, Julia; Schwetz, Verena; Ulbing, Matthias; Hutz, K.; Stiegler, P; Zigeuner, Richard; Pieber, Thomas R.; Müller, H.; Obermayer-Pietsch, B.

doi:10.1210/jc.2014-1690

Cited by 63 publications

(42 citation statements)

References 39 publications

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“…1,25-dihydroxyvitamin D has both genomic and non-genomic effects on Sertoli cells in the testes leading to increased testosterone steroidogenesis in cell culture models. [7,8] However, supplemental trials in adult men have shown inconsistent findings with one study showing vitamin D supplementation modestly increased serum T levels[16] and another study finding null results. [13] Therefore, whether treating vitamin D deficiency can improve a low T state directly is inconclusive at this time, and our data does not support a relationship beyond shared risk factors.…”

Section: Discussionmentioning

confidence: 99%

“…[5,6] The active metabolite of vitamin D, 1,25-dihydroxyvitamin D, regulates a number of enzymes involved in steroid hormone production, including both adrenal steroid hormones and sex hormones, as well as sex hormone signaling. [7,8]…”

Section: Introductionmentioning

confidence: 99%

“…[16] Data from testicular cell cultures suggest that vitamin D, especially 1,25-dihydroxyvitamin D3, has a major role in male steroidogenesis. [7]…”

Section: Introductionmentioning

confidence: 99%

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Serum vitamin D and sex hormones levels in men and women: The Multi-Ethnic Study of Atherosclerosis (MESA)

et al. 2017

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Introduction 25-hydroxyvitamin D [25(OH)D] deficiency has been associated with low testosterone levels in men, but there are conflicting reports of its associations with sex hormones in women. Less is known about whether these associations are independent of adiposity and lifestyle factors, and whether they differ by race/ethnicity. Aim To examine associations of 25(OH)D concentrations with sex hormone levels. Methods Cross-sectional analysis of 3017 men and 2929 women in a multi-ethnic cohort. Main Outcome Measures Testosterone, estradiol, dehydroepiandrosterone (DHEA), sex hormone binding globulin (SHBG), and free testosterone. Results The mean (SD) levels of 25(OH)D in men and women were 25.7(10.4) and 26.1(12.0) ng/ml, respectively. In men, after adjusting for demographic and lifestyle variables, a 10 ng/ml [25 nmol/L] decrease in 25(OH)D was associated with an average difference of −0.70 nmol/L (95%CI −1.36, −0.05) in SHBG and 0.02 percent (0.01, 0.04) in free testosterone, but was not associated with low total testosterone level (<10.41 nmol/L). In women, a 10 ng/ml decrease in 25(OH)D levels was associated with an average difference of −0.01 nmol/L (−0.01, −0.00) for estradiol, −8.29 nmol/L (−10.13, −6.45) for SHBG, 0.06 percent (0.04, 0.07) for free testosterone, and 0.40 nmol/L (0.19, 0.62) for DHEA. There was no significant interaction by race/ethnicity. Conclusions Lower 25(OH)D concentrations were associated with lower SHBG levels and higher free testosterone levels in both men and women, and lower estradiol and higher DHEA levels in women, independent of adiposity and lifestyle. We observed no significant association of 25(OH)D with total testosterone in men. Future studies are needed to determine whether vitamin D supplementation influences sex hormone levels.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum vitamin D and sex hormones levels in men and women: The Multi-Ethnic Study of Atherosclerosis (MESA)

et al. 2017

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“…VDR-knockout female mice show reproductive defect due to impaired follicle maturation [14], which is possibly due to the accumulation of androgens via UGT2B15 defectiveness, as found in the present study. The VDR also plays a role in regulating testicular androgen production [29]. VDR ligands suppress UGT2B15 expression in the prostate [4,11].…”

Section: Discussionmentioning

confidence: 99%

Regulation of uridine diphosphate-glucuronosyltransferase 2B15 expression during ovulation in the rat

et al. 2017

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“…Evidence also exists for vitamin D to play a role in fertility and steroidogenesis. However, randomized controlled trials are warranted to further investigate this possible effect [57,58,59]. In summary, again current evidence is scarce and definite conclusions on the role of vitamin D in non-skeletal diseases cannot be drawn at the moment; future studies might provide evidence on positive extraskeletal effects of vitamin D.…”

Section: Extraskeletal Diseases and Vitamin Dmentioning

confidence: 99%

Beneficial Effects of UV-Radiation: Vitamin D and beyond

Trummer

Pandis

Verheyen

et al. 2016

IJERPH

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Aside from its well-known effects on bone and mineral metabolism, vitamin D may also play an important role in extra-skeletal processes like immunologic diseases, cancer, or cardiovascular diseases. Even though meta-analyses showed that vitamin D supplementation reduces fractures, falls, and overall mortality, its potential benefits did not find universal acclaim. Several health care authorities published Recommended Dietary Allowances (RDAs) for vitamin D, most of them ranging from 600 to 800 international units (IU) per day, corresponding to a serum level of 25-hydroxyvitamin D of at least 20 ng/mL (50 nmol/L). However, studies conducted in the general population revealed a much lower overall intake of vitamin D than the proposed RDAs. Thus, strategies to increase the vitamin D intake in the general population, e.g., food fortification or vitamin D supplementation, are needed to match the existing evidence and recommendations. Therefore, several currently ongoing projects aim to investigate the effect of vitamin D supplementation in the general population and try to establish food-based solutions to improve vitamin D status.

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Testicular Synthesis and Vitamin D Action

Abstract: Data from our human primary testicular cell culture model suggest that vitamin D plays a major role in male steroidogenesis in vitro.

Cited by 63 publications

References 39 publications

Serum vitamin D and sex hormones levels in men and women: The Multi-Ethnic Study of Atherosclerosis (MESA)

Serum vitamin D and sex hormones levels in men and women: The Multi-Ethnic Study of Atherosclerosis (MESA)

Regulation of uridine diphosphate-glucuronosyltransferase 2B15 expression during ovulation in the rat

Beneficial Effects of UV-Radiation: Vitamin D and beyond

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