Testicular germ cell tumors: Molecular genetic and clinicomorphological aspects

Немцова, М. В.; Андреева, Ю. Ю.

doi:10.17650/1726-9776-2015-1-12-19

Cited by 3 publications

(1 citation statement)

References 22 publications

(23 reference statements)

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“…According to the published data, a majority of patients with CC already have metastases at the time of diagnosis. Hematogenic spread is characterized by predominant involvement of the lungs, brain, and occasionally liver and retroperitoneal lymph nodes [ 8 ]. There were individual cases of metastatic lesions of the skin [ 9 ] and pancreas [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Metastasis of Testicular Choriocarcinoma in the Stomach, Complicated by the Development of Choriocarcinoma Syndrome

Подзолков¹,

Pokrovskaya²,

Тарзиманова³

et al. 2021

Case Rep Gastroenterol

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Choriocarcinoma (CC) is a very rare and aggressive neoplasm. The characteristic feature of this disease is a rapid hematogenous spread, mainly to the lungs and brain, which largely defines clinical signs of the disease and complicates the diagnosis. Gastrointestinal metastases are rare, and of those, only few cases with gastric location have been reported. There are publications describing choriocarcinoma syndrome (CCS). As a rule, it presents in patients with an advanced disease and is characterized by hemorrhage from metastatic foci, leading to hemoptysis and gastrointestinal bleeding. CCS development is associated with poor prognosis and high mortality. This article describes a case of testicular CC with rare few gastric metastases, complicated by CCS.

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Section: Discussionmentioning

confidence: 99%

Metastasis of Testicular Choriocarcinoma in the Stomach, Complicated by the Development of Choriocarcinoma Syndrome

Подзолков¹,

Pokrovskaya²,

Тарзиманова³

et al. 2021

Case Rep Gastroenterol

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Polymorphisms of KITLG, SPRY4, and BAK1 genes in patients with testicular germ cell tumors and individuals with infertility associated with AZFc deletion of the Y chromosome

et al. 2016

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Полиморфизмы генов KITLG , SPRY4 и BAK1 у больных с герминогенными опухолями яичка и у лиц с бесплодием, связанным с делецией локуса AZFc хромосомы Y

Mv¹,

et al. 2016

Молекул. биол.

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Testicular cancer is the most common form of solid cancer in young men. Testicular cancer is represented by testicular germ cell tumors (TGCTs) derived from embryonic stem cells with different degrees of differentiation in about 95% of cases. The development of these tumors is related to the formation of a pool of male germ cells and gametogenesis. Clinical factors that are predisposed to the development of germ-cell tumors include cryptorchidism and testicular microlithiasis, as well as infertility associated with the gr/gr deletion within the AZFс locus. KITLG, SPRY4, and BAK1 genes affect the development of the testes and gametogenesis; mutations and polymorphisms of these genes lead to a significant increase in the risk of the TGCT development. To determine the relationship between gene polymorphisms and the development of TGCTs, we developed a system for detection and studied the allele and genotype frequencies of the KITLG (rs995030, rs1508595), SPRY4 (rs4624820, rs6897876), and BAK1 (rs210138) genes in fertile men, patients with TGCTs, and patients with infertility that have the AZFс deletion. A significant association of rs995030 of the KITLG gene with the development of TGCTs (p = 0.029 for the allele G, p = 0.0124 for the genotype GG) was revealed. Significant differences in the frequencies of the studied polymorphisms in patients with the AZFc deletion and the control group of fertile men were not found. We showed significant differences in the frequencies for the combination of all high-risk polymorphisms in the control group, patients with the AZFc deletion and patients with TGCTs (p (TGCTs-AZF-control) = 0.0207). A fivefold increase in the frequency of the combination of all genotypes in the TGCT group (p = 0.0116; OR = 5.25 [1.44-19.15]) and 3.7-fold increase was identified in patients with the AZFc deletion (p = 0.045; OR = 3.69 [1.11-12.29]) were revealed. The genotyping of patients with infertility caused by the AZFc deletion can be used to identify individuals with an increased risk of TGCTs.

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Testicular germ cell tumors: Molecular genetic and clinicomorphological aspects

Cited by 3 publications

References 22 publications

Metastasis of Testicular Choriocarcinoma in the Stomach, Complicated by the Development of Choriocarcinoma Syndrome

Metastasis of Testicular Choriocarcinoma in the Stomach, Complicated by the Development of Choriocarcinoma Syndrome

Polymorphisms of KITLG, SPRY4, and BAK1 genes in patients with testicular germ cell tumors and individuals with infertility associated with AZFc deletion of the Y chromosome

Полиморфизмы генов KITLG , SPRY4 и BAK1 у больных с герминогенными опухолями яичка и у лиц с бесплодием, связанным с делецией локуса AZFc хромосомы Y

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