Testicular expression of long non–coding RNAs is affected by curative GnRHa treatment of cryptorchidism

Hadžiselimović, Faruk; Verkauskas, Gilvydas; Vincel, Beata; Stadler, Michael

doi:10.1186/s12610-019-0097-3

Cited by 15 publications

(12 citation statements)

References 60 publications

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“…A study on azoospermia in cryptorchidism shows that gonadotropin-releasing hormone agonist treatment of cryptorchidism affects the expression of lncRNA in the testis. In this study, it is confirmed that LINC-ROR, LINC00221, LINC00261, LINC00282, LINC00293, LINC00303, LINC00898, LINC00994, LINC01121 and LINC01553 may play a role in the early stage of spermatogonial stem cell development ( 76 ).…”

Section: Lncrnasupporting

confidence: 73%

The gene regulatory role of non-coding RNAs in non-obstructive azoospermia

Zhou

Zhang

et al. 2022

Front. Endocrinol.

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Non-coding RNAs are classified as small non-coding RNAs, long non-coding RNAs and circular RNAs, which are involved in a variety of biological processes, including cell differentiation, proliferation, apoptosis and pathological conditions of various diseases. Many studies have shown that non-coding RNAs are related to spermatogenesis, maturation, apoptosis, function, etc. In addition, the expression of non-coding RNAs in testicular tissue and semen of patients with non-obstructive azoospermia was different. However, the role of non-coding RNAs in the pathogenesis of non-obstructive azoospermia has not been fully elucidated, and the role of non-coding RNAs in non-obstructive azoospermia is rarely reviewed. Here we summarize the research progress of non-coding RNAs in the pathogenesis of non-obstructive azoospermia.

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Section: Lncrnasupporting

confidence: 73%

The gene regulatory role of non-coding RNAs in non-obstructive azoospermia

Zhou

Zhang

et al. 2022

Front. Endocrinol.

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“…SH3BP5‐AS1 is significantly upregulated in neuroblastoma [29]. MTOR‐AS1 is associated with cryptorchidism [30]. RPS6KA2‐AS1 is considered a potential biomarker of acute stroke and is involved in the neurotrophin signaling pathway [31].…”

Section: Discussionmentioning

confidence: 99%

Identification of hub lncRNAs in head and neck cancer based on weighted gene co‐expression network analysis and experiments

Shao

2021

FEBS Open Bio

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Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most common cancer among systemic malignant tumors, with 600 000 new cases occurring every year worldwide. Since HNSCC has high heterogeneity and complex pathogenesis, no effective prognostic indicator has yet been identified. Here, we aimed to identify a lncRNA signature associated with the prognosis of HNSCC as a potential new biomarker. LncRNA expression data were downloaded from The Cancer Genome Atlas database. A polygenic risk score model was constructed by using Lasso–Cox regression analysis. Weighted gene co‐expression network analysis (WGCNA) was applied to analyze the co‐expression modules of lncRNAs associated with the prognosis of HNSCC. The robustness of the signature was validated in testing and external cohorts. Polymerase chain reaction was performed to detect the expression levels of identified lncRNAs in cancer and adjacent tissues. We constructed an 8‐lncRNA signature (LINC00567, LINC00996, MTOR‐AS1, PRKG1‐AS1, RAB11B‐AS1, RPS6KA2‐AS1, SH3BP5‐AS1, ZNF451‐AS1) that could be used as an independent prognostic factor of HNSCC. The signature showed strong robustness and had stable prediction performance in different cohorts. WGCNA results showed that modules related to risk score mainly participated in biological processes such as blood vessel development, positive regulation of catabolic processes, and regulation of growth. The prognostic risk score model based on lncRNA for HNSCC may help clinicians conduct individualized treatment plans.

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“…Cryptorchidism is an endocrinopathy considered as an important cause of male infertility [42]. The current study evaluated the effects of aqueous and methanolic extracts of R. apetalus on various reproductive (organ weights, spermatozoa parameters, testicular proteins, sex hormones, fertility potential and morphometric characteristics of testis) and metabolic (oxidative stress markers) parameters in unilateral induced cryptorchid rats.…”

Section: Discussionmentioning

confidence: 99%

Rubus apetalus (Rosaceae) improves spermatozoa characteristics, antioxidant enzymes and fertility potential in unilateral cryptorchid rats

Munyali¹,

Momo²,

Fozin³

et al. 2020

Basic Clin. Androl.

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Background: Cryptorchidism (CPT) is an important cause of male infertility. Rubus apetalus is a medicinal plant with a powerful antioxidant potential. We investigated the effects of aqueous and methanolic extracts of R. apetalus on spermatozoa parameters, antioxidant enzymes and fertility potential of rats with experimental unilateral CPT. Method: Normal (n = 15), sham-operated (n = 15) and cryptorchid rats (n = 80; distributed into 16 groups of 5 rats/ group) were treated for 2, 4 or 8 weeks with either distilled water (10 ml/kg/day), vitamin E (75 mg/kg/day), aqueous or methanolic extract of R. apetalus (12 and 60 mg/kg). Sex organ weights, spermatozoa parameters, testicular proteins, sex hormones, fertility potential, morphometric characteristics of testis and oxidative stress markers were measured. Results: CPT significantly (p < 0.05-0.001) decreased testicular and epididymal weights, spermatozoa density, spermatozoa motility, spermatozoa normality, testicular proteins, LH, FSH and testosterone concentrations. In cryptorchid rats, peri-vascular fibrosis significantly increased (p < 0.001), while diameter of the seminiferous tube, germ cell thickness, gestation index and fertility index decreased when compared to control. Additionally, CPT induced oxidative stress by increasing lipid peroxidation and by reducing superoxide dismutase and catalase activities. These alterations were corrected by R. apetalus. For instance, a significantly increase (p < 0.05-0.001) in spermatozoa motility, normality, viability and density after 2, 4 and 8 weeks of treatment was noticed. R. apetalus also increased (p < 0.05-0.001) testicular proteins, gestation index (90-100%) and fertility index (90-100%), compared to the untreated cryptorchid rats. Conclusion: R. apetalus boosts fertility potential in cryptorchid rats and could be considered as a promising alternative agent for the management of infertility associated with CPT.

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Testicular expression of long non–coding RNAs is affected by curative GnRHa treatment of cryptorchidism

Cited by 15 publications

References 60 publications

The gene regulatory role of non-coding RNAs in non-obstructive azoospermia

The gene regulatory role of non-coding RNAs in non-obstructive azoospermia

Identification of hub lncRNAs in head and neck cancer based on weighted gene co‐expression network analysis and experiments

Rubus apetalus (Rosaceae) improves spermatozoa characteristics, antioxidant enzymes and fertility potential in unilateral cryptorchid rats

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