Test–retest repeatability of myocardial blood flow and infarct size using 11C-acetate micro-PET imaging in mice

Croteau, Étienne; Renaud, Jennifer; McDonald, Matthew A.; Klein, Ran; DaSilva, Jean N.; deKemp, Robert A.

doi:10.1007/s00259-015-3111-9

Cited by 8 publications

(10 citation statements)

References 37 publications

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“…Chemokine Receptor Type-2 C-C chemokine receptor type 2 (CCR2) is another important inflammatory cell marker involved in monocyte/macrophage recruitment, which has been evaluated for imaging myocardial inflammation using PET. In an ischaemia-reperfusion heterotopic heart transplantation mouse model, the PET tracer 64 Cu-DOTA-ECL1i was shown to bind CCR2 + monocytes and macrophages within donor hearts, demonstrating increased tracer uptake compared to native hearts [43]. Specific autoradiographic binding was also confirmed in human myocardial specimens.…”

Section: Tracers For Imaging Post-infarct Inflammationmentioning

confidence: 78%

Section: Tracers For Imaging Post-infarct Inflammationmentioning

confidence: 99%

“…Macrophage Phagocytosis 64 Cu-Macrin is a 20-nm spherical dextran nanoparticle tracer designed specifically to target macrophages. In a preclinical study, 64 Cu-Macrin was shown to report on the accumulation of macrophages within the infarcted myocardium in experiments using mice, rabbits and pigs [45•]. Increases in lung and cardiac 64 Cu-Macrin PET signals were also observed in mouse models of sepsis and pneumonia, in newborn mice exhibiting higher macrophage content than adults, and in atherosclerotic plaques in rabbits.…”

Section: Tracers For Imaging Post-infarct Inflammationmentioning

confidence: 99%

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PET Imaging of Post-infarct Myocardial Inflammation

et al. 2021

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Purpose of Review To examine the use of positron emission tomography (PET) for imaging post-infarct myocardial inflammation and repair. Recent Findings Dysregulated immune responses after myocardial infarction are associated with adverse cardiac remodelling and an increased likelihood of ischaemic heart failure. PET imaging utilising novel tracers can be applied to visualise different components of the post-infarction inflammatory and repair processes. This approach could offer unique pathophysiological insights that could prove useful for the identification and risk-stratification of individuals who would ultimately benefit most from emerging immune-modulating therapies. PET imaging could also bridge the clinical translational gap as a surrogate measure of drug efficacy in early-stage clinical trials in patients with myocardial infarction. The use of hybrid PET/MR imaging, in particular, offers the additional advantage of simultaneous in vivo molecular imaging and detailed assessment of myocardial function, viability and tissue characterisation. Summary Further research is needed to realise the true clinical translational value of PET imaging after myocardial infarction.

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Section: Tracers For Imaging Post-infarct Inflammationmentioning

confidence: 78%

Section: Tracers For Imaging Post-infarct Inflammationmentioning

confidence: 99%

Section: Tracers For Imaging Post-infarct Inflammationmentioning

confidence: 99%

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PET Imaging of Post-infarct Myocardial Inflammation

et al. 2021

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“…Previously, the usage of 99mTc-sestamibi and 13N-ammonia PET showed a valid assessment of cardiac function in healthy and infarct mice compared to MRI and contrast CT ( 28 ). Furthermore, Croteau et al depicted a robust test and retest repeatability for mouse infarct assessment by using 11C-acetate micro-PET imaging ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

Cardiac 18F-FDG Positron Emission Tomography: An Accurate Tool to Monitor In vivo Metabolic and Functional Alterations in Murine Myocardial Infarction

Fischer

Zacherl

Weckbach

et al. 2021

Front. Cardiovasc. Med.

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Cardiac monitoring after murine myocardial infarction, using serial non-invasive cardiac 18F-FDG positron emissions tomography (PET) represents a suitable and accurate tool for in vivo studies. Cardiac PET imaging enables tracking metabolic alterations, heart function parameters and provides correlations of the infarct size to histology. ECG-gated 18F-FDG PET scans using a dedicated small-animal PET scanner were performed in mice at baseline, 3, 14, and 30 days after myocardial infarct (MI) by permanent ligation of the left anterior descending (LAD) artery. The percentage of the injected dose per gram (%ID/g) in the heart, left ventricular metabolic volume (LVMV), myocardial defect, and left ventricular function parameters: end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and the ejection fraction (EF%) were estimated. PET assessment of the defect positively correlates with post-infarct histology at 3 and 30 days. Infarcted murine hearts show an immediate decrease in LVMV and an increase in %ID/g early after infarction, diminishing in the remodeling process. This study of serial cardiac PET scans provides insight for murine myocardial infarction models by novel infarct surrogate parameters. It depicts that serial PET imaging is a valid, accurate, and multimodal non-invasive assessment.

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“…Importantly, in the study by Hess et al, heart rate of mice was in the physiological range (on average 477 beatsÁminute -1 ) as recommended in the guidelines. 1 Nuclear imaging in small animal models of ischemic heart disease is appealing, because it enables accurate measurement of MI size, 5-9 evaluation of myocardial perfusion, 10,11 and molecular imaging of metabolism such as oxygen consumption combined with substrate metabolism. 12,13 However, previous studies evaluating nuclear imaging for the assessment of cardiac volumes and function have been mainly focused on other conditions than MI.…”

Section: See Related Article Pp 1317-1327mentioning

confidence: 99%