Terpenoids Isolated from Psidium guajava Hexane Extract with Depressant Activity on Central Nervous System

Antiplasmodial activity of certain medicinal plants against chloroquine resistant Plasmodium berghei infected white albino BALB/c mice

“…The fruits are edible and are rich source of vitamin C and minerals. The leaf extract has a broad spectrum of activities against cough, bacterial infections, heamostasis (Jairaj et al 1999(Jairaj et al , 2000, diarrheas and narcotic properties (Lozoya et al 1990), antidiabetic (Obatomi et al 1994), antioxidant (Qian and Nihorimbere 2004), antimutagenic (Grover and Bala 1993;Matsuo et al 1994), abdominal pain, convulsions, epilepsy, cholera, insomnia and hypnotic effects (Lutterodt and Maleque, 1988;Meckes et al 1996). Our effort was to evaluate its leaf and unripe fruits for antimalarial activity.…”

Hydroalcoholic Extract of Cuscuta Epithymum Enhances Pentobarbitalinduced Sleep: Possible Involvement of GABAergic System

“…Kambe et al (2010) ▶ demonstrated that quercetin increases non-rapid eye movement sleep in dark period in rats. The depressant activity of some terpenoids in the central nervous system has also been reported by Meckes et al (1996) ▶ . Although we did not investigate the exact compound responsible for sleep prolonging effect of P. eldarica , quercetin and some terpenoids might be involved in this effect.…”

Essential Oil from the Leaves of Chromolaena odorata, and Sesquiterpene Caryophyllene Oxide Induce Sedative Activity in Mice

“…Moreover, administration of flumazenil did not change the sleeping time, which suggested that caryophyllene oxide does not operate via the GABAergic receptor system. Conversely, a work in which caryophyllene oxide was extracted from Psidium guajava L. hexanolic leaves, demonstrated that it increased the sleeping time induced by pentobarbital [ 39 ]. In this study, the authors utilized different dosage and methodology and caryophyllene oxide obtained only in traces was administered intraperitoneally whereas our study was performed on pure caryophyllene oxide administered via inhalation.…”