Terpenes in ethanol: haloperidol permeation and partition through human skin and stratum corneum changes

Vaddi, H.K; Ho, Peiying; Chan, Yew Weng; Chan, Sui Yung

doi:10.1016/s0168-3659(02)00057-3

Cited by 112 publications

(59 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The first three endotherms were obtained at 34 C (T 1 ), 83.13 C (T 2 ), and 104.56 C (T 3 ), respectively. Whereas, the fourth endotherm (T 4 ) produced a very sharp and prominent peak at 114 C which is attributed to stratum corneum proteins (Yamane et al 1995;Vaddi et al 2002b;Narishetty and Panchagnula 2004a). The first endotherm (having the lowest enthalpy) is attributed to sebaceous secretions (Lee et al 2005) or surface contamination and to minor structural rearrangement of lipid bilayer and is some time completely removed by lipid extracting solvents (Yamane et al 1995).…”

Section: Discussionmentioning

confidence: 99%

The application of anethole, menthone, and eugenol in transdermal penetration of valsartan: Enhancement and mechanistic investigation

Ahad

Aqil

Ali

2015

Pharmaceutical Biology

View full text Add to dashboard Cite

Context:The main barrier for transdermal delivery is the obstacle property of the stratum corneum. Many types of chemical penetration enhancers have been used to breach the skin barrier; among the penetration enhancers, terpenes are found as the most highly advanced, safe, and proven category. Objective: In the present investigation, the terpenes anethole, menthone, and eugenol were used to enhance the permeation of valsartan through rat skin in vitro and their enhancement mechanism was investigated. Materials and methods: Skin permeation studies of valsartan across rat skin in the absence and the presence of terpenes at 1% w/v, 3% w/v, and 5% w/v in vehicle were carried out using the transdermal diffusion cell sampling system across rat skin and samples were withdrawn from the receptor compartment at 1, 2, 3, 4, 6, 8, 10, 12, and 24 h and analysed for drug content by the HPLC method. The mechanism of skin permeation enhancement of valsartan by terpenes treatment was evaluated by Fourier transform infrared spectroscopy (FTIR) analysis and differential scanning calorimetry (DSC). Results: All the investigated terpenes provided a significant (p50.01) enhancement in the valsartan flux at a concentration of 1%, and less so at 3% and 5%. The effectiveness of terpenes at 1% concentration was in the following order: anethole4menthone4eugenol with 4.4-, 4.0-, and 3.0-fold enhancement ratio over control, respectively. DSC study showed that the treatment of stratum corneum with anethole shifted endotherm down to lower melting point while FTIR studies revealed that anethole produced maximum decrease in peak height and area than other two terpenes. Conclusion: The investigated terpenes can be successfully used as potential enhancers for the enhancement of skin permeation of lipophilic drug. ARTICLE HISTORY

show abstract

Section: Discussionmentioning

confidence: 99%

The application of anethole, menthone, and eugenol in transdermal penetration of valsartan: Enhancement and mechanistic investigation

Ahad

Aqil

Ali

2015

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…Utilization of chemical permeation enhancers in preparation of nanoparticles can overcome the barrier function of skin. [24][25][26] Different types of film dressing materials are available, including chitin, chitosan, Tegaderm™ (3M Health Care, Borken, Germany), hydrocolloid, biofilm, and alginate. 27,28 Alginate film is the most widely recommended dressing in the diabetic population, having a good safety profile and being suitable for application on wounds.…”

Section: Introductionmentioning

confidence: 99%

Dual drug-loaded nanoparticles on self-integrated scaffold for controlled delivery

Bennet¹,

Marimuthu²,

Kim³

et al. 2012

IJN

View full text Add to dashboard Cite

Antioxidant (quercetin) and hypoglycemic (voglibose) drug-loaded poly-D,L-lactideco-glycolide nanoparticles were successfully synthesized using the solvent evaporation method. The dual drug-loaded nanoparticles were incorporated into a scaffold film using a solvent casting method, creating a controlled transdermal drug-delivery system. Key features of the film formulation were achieved utilizing several ratios of excipients, including polyvinyl alcohol, polyethylene glycol, hyaluronic acid, xylitol, and alginate. The scaffold film showed superior encapsulation capability and swelling properties, with various potential applications, eg, the treatment of diabetes-associated complications. Structural and light scattering characterization confirmed a spherical shape and a mean particle size distribution of 41.3 nm for nanoparticles in the scaffold film. Spectroscopy revealed a stable polymer structure before and after encapsulation. The thermoresponsive swelling properties of the film were evaluated according to temperature and pH. Scaffold films incorporating dual drug-loaded nanoparticles showed remarkably high thermoresponsivity, cell compatibility, and ex vivo drug-release behavior. In addition, the hybrid film formulation showed enhanced cell adhesion and proliferation. These dual drugloaded nanoparticles incorporated into a scaffold film may be promising for development into a transdermal drug-delivery system.

show abstract

“…Increase in enthalpy and transition T m1 by Labrafil and Capryol may due to bilayer cohesion [20], which is in contrast to lipid extraction and fluidization. The shift in Tm to lower temperatures can be interpreted as disruption of the lipid bilayer and the irreversible denaturation of proteins in the SC layer of skin, while decrease in ∆H is related to fluidization of lipid in lipid bilayer and lipid -protein complex [14][15][16][17][18][19].…”

Section: Discussionmentioning

confidence: 95%

Effect of the Various Solvents on the <i>In Vitro</i> Permeability of Vitamin B<sub>12</sub> through Excised Rat Skin

Moghimipour¹,

Salimi²,

Makhmalzadeh³

2013

Trop. J. Pharm Res

View full text Add to dashboard Cite

Terpenes in ethanol: haloperidol permeation and partition through human skin and stratum corneum changes

Cited by 112 publications

References 25 publications

The application of anethole, menthone, and eugenol in transdermal penetration of valsartan: Enhancement and mechanistic investigation

The application of anethole, menthone, and eugenol in transdermal penetration of valsartan: Enhancement and mechanistic investigation

Dual drug-loaded nanoparticles on self-integrated scaffold for controlled delivery

Effect of the Various Solvents on the <i>In Vitro</i> Permeability of Vitamin B<sub>12</sub> through Excised Rat Skin

Contact Info

Product

Resources

About