Terahertz spectra of DNA nucleobase crystals: A joint experimental and computational study

Wang, Fang; Zhao, Dongbo; Dong, Hao; Jiang, Ling; Liu, Yunfei; Li, Shuhua

doi:10.1016/j.saa.2017.02.037

Cited by 32 publications

(19 citation statements)

References 29 publications

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“…Presumably, these absorption peaks, at 3.44 THz and 3.89 THz of A, at 5.30 THz of C and at 1.69 THz of U, claimed in [27] are not observed in our work or others and these peaks also cannot be distinguished clearly in Figure 2a in [27]. These “unique case” peaks may be noise signals because of the large mass of the sample pellets in [27] among these mentioned works [26,27,28,29], or they could have originated from the interaction between purine and the water molecules during recrystallization [43]. The characteristic absorption peaks at 2.07 and 2.82 THz of T claimed in [28] are not repeated in our study or others.…”

Section: Discussionmentioning

confidence: 50%

“…All the absorption peaks of five nucleobases of DNA/RNA measured in this work and other reports previously are summarized in Table 2 for further comparison and analysis [26,27,28,29].…”

Section: Discussionmentioning

confidence: 90%

“…There is a great difference in intensity of the resonance absorption between different molecule systems under the different frequencies. The weak absorption peaks at some frequencies become clear gradually with the increase of mass, but at some frequencies, the strong absorption leads to a lot of jittery spikes which hinder distinguishing the exact positions of absorption peaks, so then referring [26,27,28,29], we mixed in PE to dilute the mass of tested objects for measurement and analysis. Therefore, this technique has a great significance to detect different masses of samples to obtain complete characteristic absorption peaks in THz time-domain spectrum analysis.…”

Section: Discussionmentioning

confidence: 99%

“…Up to now, spectral information of nucleobases above 5 THz was not available by using the traditional THz-TDS techniques. Besides, there are some notable differences in the results reported by different research groups [26,27,28,29]. The incompleteness and the uncertainty of spectral information for these base-pairs might affect the correct understanding of the DNA/RNA biomolecular structures and functions.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Characterization of Nucleobases in Broadband Terahertz Spectra from 0.5 to 10 THz with the Air-Biased-Coherent-Detection Technique

Yan

Sun

et al. 2019

Sensors

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Terahertz time-domain spectroscopy (THz-TDS) is an effective coherent detection technique for deeply understanding the structures and functions of biomolecules. However, generally not full information in the whole THz range can be obtained due to the limited detection bandwidth (usually less than 5 THz) of the traditional THz-TDS systems. In this paper, effective THz absorption spectra in 0.5–10 THz range of five typical nucleobases of DNA/RNA are characterized with a super broadband THz detection technique, called the air-biased- coherent-detection (THz-ABCD) technique. Few unexpected characteristic absorption peaks appeared in the low-frequency region and meanwhile a series of anticipated characteristic absorption peaks are found in the high-frequency region. The fingerprint spectra of these nucleobases are helpful for further analysis on the vibration and twisting behavior of hydrogen bonds, van der Waals and electrostatic forces etc. between and within DNA/RNA biomolecules.

show abstract

Section: Discussionmentioning

confidence: 50%

“…All the absorption peaks of five nucleobases of DNA/RNA measured in this work and other reports previously are summarized in Table 2 for further comparison and analysis [26,27,28,29].…”

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Characterization of Nucleobases in Broadband Terahertz Spectra from 0.5 to 10 THz with the Air-Biased-Coherent-Detection Technique

Yan

Sun

et al. 2019

Sensors

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show abstract

“…Given that proteins require water to function in living bodies, studying biomolecules in physiological solution has more practical significance. However, the use of THz spectroscopy to analyze aqueous samples has long been hampered by the strong THz absorption of water since the permanent dipole of water dominates and often masks any specific THz absorption which may occur from known biomolecules in solution [7,8].…”

Section: Introductionmentioning

confidence: 99%

Terahertz Spectroscopic Signatures of Microcystin Aptamer Solution Probed with a Microfluidic Chip

Zhang

Yang

Tang

et al. 2019

Sensors

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Terahertz signature detection of biological samples in aqueous solution remains a great challenge due to the strong terahertz absorption of water. Here we propose a new preparation process for fabricating a microfluidic chip and use it as an effective sensor to probe the terahertz absorption signatures of microcystin aptamer (a linear single-stranded DNA with 60 nucleotides) dissolved in TE buffer with different concentrations. The microfluidic chip made of silicon includes thousands of 2.4 μm × 2.4 μm square-cross-section channels. One repeatable terahertz absorption signature is detected and recognized around 830 GHz, fitted to a Lorentz oscillator. This signature is theorized to originate from the bending of hydrogen bonds formed between adjacent hydrated DNA bases surrounded by water molecules. Furthermore, the low-lying vibrational modes are also investigated by molecular dynamics simulations which suggest that strong resonant oscillations are highly probable in the 815–830 GHz frequency band.

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Ultra‐Broadband Wide‐Angle Terahertz Absorption Properties of 3D Graphene Foam

Huang

Chen

Huang

et al. 2017

Adv Funct Materials

260

137

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As a next generation of detection technology, terahertz technology is very promising. In this work, a highly efficient terahertz wave absorber based on 3D graphene foam (3DG) is first reported. Excellent terahertz absorption property at frequency ranging from 0.1 to 1.2 THz is obtained owing to faint surface reflection and enormous internal absorption. By precise control of the constant properties for 3DG, the reflection loss (RL) value of 19 dB is acquired and the qualified frequency bandwidth (with RL value over 10 dB) covers 95% of the entire measured bandwidth at normal incidence, which far surpasses most reported materials. More importantly, the terahertz absorption performance of 3DG enhances obviously with increasing the incidence while majority of materials become invalid at oblique incidence, instead. At the incidence of 45°, the maximum RL value increases 50% from 19 to 28.6 dB and the qualified frequency bandwidth covers 100% of the measured bandwidth. After considering all core indicators involving density, qualified bandwidth, and RL values, the specific average terahertz absorption (SATA) property is investigated. The SATA value of 3DG is over 3000 times higher than those of other materials in open literatures.

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Terahertz spectra of DNA nucleobase crystals: A joint experimental and computational study

Cited by 32 publications

References 29 publications

Characterization of Nucleobases in Broadband Terahertz Spectra from 0.5 to 10 THz with the Air-Biased-Coherent-Detection Technique

Characterization of Nucleobases in Broadband Terahertz Spectra from 0.5 to 10 THz with the Air-Biased-Coherent-Detection Technique

Terahertz Spectroscopic Signatures of Microcystin Aptamer Solution Probed with a Microfluidic Chip

Ultra‐Broadband Wide‐Angle Terahertz Absorption Properties of 3D Graphene Foam

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