Terahertz radiation influence on peptide conformation

Черкасова, О. П.; Федоров, В. И.; Немова, Е. Ф.; Popova, S. S.; Pogodin, A. S.; Khamoyan, A. G.

doi:10.1117/12.752431

Cited by 6 publications

(4 citation statements)

References 2 publications

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“…As the result, changes in the UV and circular dichroism (CD) spectra of the irradiated protein were observed. They were attributed to modifications in the BSA conformation, as was further confirmed by an increase in the Trp fluorescence of BSA 212 and a twofold decrease in the progesterone binding constant. 211 , 212 In Ref.…”

Section: Terahertz Exposure Of Biological Objects With Different Levels Of Organizationmentioning

confidence: 70%

“…They were attributed to modifications in the BSA conformation, as was further confirmed by an increase in the Trp fluorescence of BSA 212 and a twofold decrease in the progesterone binding constant. 211 , 212 In Ref. 213 , BSA was exposed, for 60 min, to the pulsed THz radiation with the 0.2- to 1.5-THz spectral bandwidth and the peak irradiance of

(or the average irradiance of

), whereas the sample was in the form of thin films on a crystalline

substrate.…”

Section: Terahertz Exposure Of Biological Objects With Different Levels Of Organizationmentioning

confidence: 70%

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Cellular effects of terahertz waves

et al. 2021

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. Significance: An increasing interest in the area of biological effects at exposure of tissues and cells to the terahertz (THz) radiation is driven by a rapid progress in THz biophotonics, observed during the past decades. Despite the attractiveness of THz technology for medical diagnosis and therapy, there is still quite limited knowledge about safe limits of THz exposure. Different modes of THz exposure of tissues and cells, including continuous-wave versus pulsed radiation, various powers, and number and duration of exposure cycles, ought to be systematically studied. Aim: We provide an overview of recent research results in the area of biological effects at exposure of tissues and cells to THz waves. Approach: We start with a brief overview of general features of the THz-wave–tissue interactions, as well as modern THz emitters, with an emphasis on those that are reliable for studying the biological effects of THz waves. Then, we consider three levels of biological system organization, at which the exposure effects are considered: (i) solutions of biological molecules; (ii) cultures of cells, individual cells, and cell structures; and (iii) entire organs or organisms; special attention is devoted to the cellular level. We distinguish thermal and nonthermal mechanisms of THz-wave–cell interactions and discuss a problem of adequate estimation of the THz biological effects’ specificity. The problem of experimental data reproducibility, caused by rareness of the THz experimental setups and an absence of unitary protocols, is also considered. Results: The summarized data demonstrate the current stage of the research activity and knowledge about the THz exposure on living objects. Conclusions: This review helps the biomedical optics community to summarize up-to-date knowledge in the area of cell exposure to THz radiation, and paves the ways for the development of THz safety standards and THz therapeutic applications.

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Section: Terahertz Exposure Of Biological Objects With Different Levels Of Organizationmentioning

confidence: 70%

(or the average irradiance of

), whereas the sample was in the form of thin films on a crystalline

substrate.…”

Section: Terahertz Exposure Of Biological Objects With Different Levels Of Organizationmentioning

confidence: 70%

Cellular effects of terahertz waves

et al. 2021

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“…However, the specific component of each complex responsible for the observed effects could not be definitively confirmed, as a direct method for measuring the activity of each component of the complexes is still lacking. Given that terahertz waves have been shown to modulate protein conformation [ 43 – 45 ], one potential mechanism is that THz waves may induce structural alterations in enzymes, leading to changes in the turnover of enzymes, thereby affecting the number of active enzyme molecules in the membrane. As the control of the MMP involves both the functioning of proton pumps and the regulation of proton discharge [ 46 ], the stimulation of complex activities therefore resulted in an increase in the MMP ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Membrane-mediated modulation of mitochondrial physiology by terahertz waves

Lei,

Zhang,

et al. 2024

Biomed. Opt. Express

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Extensive studies have demonstrated the diverse impacts of electromagnetic waves at gigahertz and terahertz (THz) frequencies on cytoplasmic membrane properties. However, there is little evidence of these impacts on intracellular membranes, particularly mitochondrial membranes crucial for mitochondrial physiology. In this study, human neuroblast-like cells were exposed to continuous 0.1 THz radiation at an average power density of 33 mW/cm2. The analysis revealed that THz exposure significantly altered the mitochondrial ultrastructure. THz waves enhanced the enzymatic activity of the mitochondrial respiratory chain but disrupted supercomplex assembly, compromising mitochondrial respiration. Molecular dynamics simulations revealed altered rates of change in the quantity of hydrogen bonds and infiltration of water molecules in lipid bilayers containing cardiolipin, indicating the specific behavior of cardiolipin, a signature phospholipid in mitochondria, under THz exposure. These findings suggest that THz radiation can significantly alter mitochondrial membrane properties, impacting mitochondrial physiology through a mechanism related to mitochondrial membrane, and provide deeper insight into the bioeffects of THz radiation.

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“…During the THz irradiation of albumin protein samples there had been revealed conformational transitions of these macromolecules. These transitions had been registered by different spectroscopic methods, which let fix changes in correlation fractions of condensed and folded structures, and changes in optical albumin density in absorption area of peptid and disulfide bonds [14][15][16][17]. This indicates that THz irradiation induces conformational change in albumin molecules caused by the change in its bonding property.…”

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confidence: 99%

Regulatory effects of terahertz waves

Киричук¹,

Иванов²

2013

RusOMJ

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There are modern data about biological effects of terahertz (THz) waves in this article. Items of interaction of THz waves with bio objects of different organization level. A complex of the data indicates that the realization of a THz wave effect in biosystems is possible at molecular, cellular, tissular, organ and system levels of regulation. There are data about changes in nervous and humoral regulation of an organism and metabolic effects of THz waves.

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Terahertz radiation influence on peptide conformation

Cited by 6 publications

References 2 publications

Cellular effects of terahertz waves

Cellular effects of terahertz waves

Membrane-mediated modulation of mitochondrial physiology by terahertz waves

Regulatory effects of terahertz waves

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