Terahertz biophotonics as a tool for studies of dielectric and spectral properties of biological tissues and liquids

Smolyanskaya, O. A.; Chernomyrdin, Nikita V.; Konovko, A. A.; Zaytsev, Kirill I.; Ozheredov, I. A.; Черкасова, О. П.; Назаров, М. М.; Guillet, Jean-Paul; Kozlov, S. A.; Kistenev, Yury V.; Coutaz, Jean‐Louis; Mounaix, Patrick; Вакс, В. Л.; Son, Joo‐Hiuk; Cheon, Hwayeong; Wallace, Vincent P.; Feldman, Yuri; Попов, И. И.; Yaroslavsky, Anna N.; Shkurinov, Alexander P.; Tuchin, Valery V.

doi:10.1016/j.pquantelec.2018.10.001

Cited by 243 publications

(182 citation statements)

References 298 publications

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“…Thus, we have obtained the expected results-optical density and absorption of cancer tissue, in general, were higher than that of both mucosa and serosa, which corresponded to other research on cancer, using THz time-domain spectroscopy [8][9][10][11]. This difference could be explained by the high cell density in cancer regions [5], features of the tumor microenvironment that cause profound metabolic changes in the cells [26,27], abnormal protein density alterations, and the increase in the vasculature [27]. However, one of the main factors affecting the THz response from fresh biological tissue is an increased water content in tumors in comparison to normal tissues [8,22].…”

Section: Resultssupporting

confidence: 86%

“…Additionally, in contrast to X-rays, THz radiation has a low photon energy, that allows the performance of harmless diagnostics. Thus, THz spectroscopy and imaging methods have already been successfully used to detect tumors with different morphology and localization [5]. In recent years, there has been a growing interest in research on digestive system cancer, using THz diagnostic methods [6], which is related to the demand of clear recognition of boundaries between normal and cancer tissues during surgery or endoscopy treatment.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of Fresh Gastric Normal and Cancer Tissues Using Terahertz Time-Domain Spectroscopy

et al. 2019

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In recent times, terahertz (THz) technologies have been actively applied in many biomedical research work, including gastric cancer diagnosis. In order to provide an effective removal of tumor during surgery, it is necessary to clearly distinguish it from different membranes of the stomach. In this work, we reported an investigation of various normal and cancer fresh gastric tissues using terahertz time-domain spectroscopy in the reflection mode. Refractive index and absorption coefficient of moderately differentiated and poorly differentiated gastric adenocarcinomas, as well as both serosa and mucosa were obtained in the frequency range from 0.2 to 1 THz. All cancer tissues were distinguishable from normal ones. The influence of the morphology of the investigated tissues on the obtained optical properties is discussed. The obtained results demonstrated a potential of THz time-domain spectroscopy to discriminate a tumor from normal serous and mucous gastric membranes. Thus, this method might be applied to gastric cancer diagnosis.

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Section: Resultssupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Investigation of Fresh Gastric Normal and Cancer Tissues Using Terahertz Time-Domain Spectroscopy

et al. 2019

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“…However, since the successful implementation of ultrafast lasers [2] research in the field took off in the 1990s and has been growing ever since. Today a wide range of THz systems and applications have been developed across a broad range of sectors, including biological [3], medical [4], and industry [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Another distinct feature of THz radiation is its strong sensitivity to water and other polar liquids [3,10]. This sensitivity stems from the fact that hydrogen bonds between water molecules resonate strongly at THz frequencies, absorbing most of the incident THz radiation in the process of dipole re-orientation.…”

Section: Introductionmentioning

confidence: 99%

Non-Contact, Non-Destructive Testing in Various Industrial Sectors with Terahertz Technology

Tao

Fitzgerald

Wallace

2020

Sensors

166

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In this article, we survey various non-contact, non-destructive testing methods by way of terahertz (THz) spectroscopy and imaging designed for use in various industrial sectors. A brief overview of the working principles of THz spectroscopy and imaging is provided, followed by a survey of selected applications from three industries—the building and construction industry, the energy and power industry, and the manufacturing industry. Material characterization, thickness measurement, and defect/corrosion assessment are demonstrated through the examples presented. The article concludes with a discussion of novel spectroscopy and imaging devices and techniques that are expected to accelerate industry adoption of THz systems.

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“…Application of terahertz radiation spanning 0.1 to 10 THz is paving a new era in a wide range of fields, particularly directed toward faster, high data rate post‐5G communication network, high‐resolution imaging, stand‐off detection, and noncontact sensing of materials . More so, it is increasingly employed in research for the characterization of optical properties and screening of biological/chemical compounds based on distinctive spectral signatures resulting from vibrational modes of covalent and hydrogen bonds . The focus on this spectrally rich region is attributed to the highly coherent and nonionizing nature of terahertz radiation, wide unallocated frequency bands, distinctive wavelengths, and their penetration through a significant depth of dielectric materials.…”

Section: Introductionmentioning

confidence: 99%

Dielectrics for Terahertz Metasurfaces: Material Selection and Fabrication Techniques

Ako

Upadhyay

Withayachumnankul

et al. 2019

Advanced Optical Materials

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on distinctive spectral signatures resulting from vibrational modes of covalent and hydrogen bonds. [8,[13][14][15][16] The focus on this spectrally rich region is attributed to the highly coherent and nonionizing nature of terahertz radiation, wide unallocated frequency bands, distinctive wavelengths, and their penetration through a significant depth of dielectric materials. Terahertz technology is geared toward realizing devices that can efficiently manipulate the phase, amplitude, and polarization of terahertz radiations for the above-mentioned myriad of applications.However, progress in this domain is held back by low terahertz power available from compact sources, high free-space path loss, and limited choice of materials that exhibit less absorption of terahertz waves. [17] Owing to the fact that natural materials demonstrate weak wave-matter interaction at terahertz frequencies, terahertz devices with engineered subwavelength resonant metallic inclusions on dielectric spacers have been realized, to interact strongly with an incident electromagnetic wave.In the past, metamaterials have been a promising route to building terahertz devices. These devices have in essence been engineered as 3D resonating elements that effectively manipulate both permittivity and permeability of an effective medium to couple to free space. The underlining disadvantage of these structures is the difficulty involved in the fabrication of 3D geometrical structures using standard semiconductor fabrication techniques. Standard fabrication techniques are generally amenable to 2D design with extrusion of these structures into thickness (the third, vertical dimension). Moreover, the choice and availability of dielectric materials and metals that provide sufficient interaction while retaining device efficiency has proved challenging. [13,[18][19][20] Recently, effective manipulation of electromagnetic wave has been widely demonstrated with 2D metasurfaces, which were originally employed as building blocks for 3D metamaterials. In these lower-dimension designs, effective manipulation of terahertz waves for various applications is achieved by carefully designing sub-wavelength resonant structures as is evident in published review articles. [21,22] Metasurfaces present high degree of compactness that enhances radiation efficiency. Additionally, the planar form factor of metasurfaces enables Manipulation of terahertz radiation opens new opportunities that underpin application areas in communication, security, material sensing, and characterization. Metasurfaces employed for terahertz manipulation of phase, amplitude, or polarization of terahertz waves have limitations in radiation efficiency which is attributed to losses in the materials constituting the devices. Metallic resonators-based terahertz devices suffer from high ohmic losses, while dielectric substrates and spacers with high relative permittivity and loss tangent also reduce bandwidth and efficiency. To overcome these issues, a proper choice of low loss and low relative permittivi...

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Terahertz biophotonics as a tool for studies of dielectric and spectral properties of biological tissues and liquids

Cited by 243 publications

References 298 publications

Investigation of Fresh Gastric Normal and Cancer Tissues Using Terahertz Time-Domain Spectroscopy

Investigation of Fresh Gastric Normal and Cancer Tissues Using Terahertz Time-Domain Spectroscopy

Non-Contact, Non-Destructive Testing in Various Industrial Sectors with Terahertz Technology

Dielectrics for Terahertz Metasurfaces: Material Selection and Fabrication Techniques

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