Ten Years' Experience in the Treatment of Epilepsy With Ketogenic Diet

Acute Supplementation of Beta‐Hydroxybutyrate Increases Visual Cortical Excitability in Humans: A Combined Electro‐EncephaloGraphy and Magnetic Resonance Spectroscopy Study

“…The number of studies measuring the impact of ketone supplementation or dieting on clinical populations and animal models is much larger, and their results are exceedingly heterogeneous (Machowiec et al 2022). Many of these studies focused on epilepsy, given the long-established effect of ketogenic dieting or fasting as anticonvulsants (Helmholz and Keith 1933). The beneficial outcome of dieting is commonly interpreted as an enhancement of inhibition by increasing the GABA/Glutamate ratio.…”

“…2022). Many of these studies focused on epilepsy, given the long‐established effect of ketogenic dieting or fasting as anticonvulsants (Helmholz and Keith 1933). The beneficial outcome of dieting is commonly interpreted as an enhancement of inhibition by increasing the GABA/Glutamate ratio.…”

Acute Supplementation of Beta‐Hydroxybutyrate Increases Visual Cortical Excitability in Humans: A Combined Electro‐EncephaloGraphy and Magnetic Resonance Spectroscopy Study

“…The number of studies measuring the impact of ketone supplementation or dieting on clinical populations and animal models is much larger, and their results are exceedingly heterogeneous (Machowiec et al 2022). Many of these studies focused on epilepsy, given the long-established effect of ketogenic dieting or fasting as anticonvulsants (Helmholz and Keith 1933). The beneficial outcome of dieting is commonly interpreted as an enhancement of inhibition by increasing the GABA/Glutamate ratio.…”

“…2022). Many of these studies focused on epilepsy, given the long‐established effect of ketogenic dieting or fasting as anticonvulsants (Helmholz and Keith 1933). The beneficial outcome of dieting is commonly interpreted as an enhancement of inhibition by increasing the GABA/Glutamate ratio.…”

Ketogenic Diet in Cancer Prevention and Therapy: Molecular Targets and Therapeutic Opportunities

“…In the 1920s and 1930s, all preliminary reports that verified the effectiveness of the ketogenic diet were retrospective reports [37,44,[61][62][63][64][65][66][67][68]. Unfortunately, some of these included a small number of patients and few clinical details and it was often not clear what should be regarded as a "good" or "partial" response to the ketogenic diet.…”

Pathophysiological Abnormalities in Migraine Ameliorated by Ketosis: A Proof-of-Concept Review

“…Even so, a study from 1967 has discovered how KBs could replace glucose as the major fuel of the brain in situations of prolonged fasting or glucose deficiency, being able to provide up to 60% of the energy needs of the brain [92]. Moreover, the impact of KBs on brain function were discovered much earlier in the 1920s, as it was observed that a low-carb and high-fat diet was successful in treating paediatric epilepsy [93,94]. While the human brain mainly relies on glucose as the primary energy source, other substrates might support metabolism also, for the most part when glucose stock is confined or insufficient [95].…”

Acute Supplementation of Beta‐Hydroxybutyrate Increases Visual Cortical Excitability in Humans: A Combined Electro‐EncephaloGraphy and Magnetic Resonance Spectroscopy Study

“…The number of studies measuring the impact of ketone supplementation or dieting on clinical populations and animal models is much larger, and their results are exceedingly heterogeneous (Machowiec et al 2022). Many of these studies focused on epilepsy, given the long-established effect of ketogenic dieting or fasting as anticonvulsants (Helmholz and Keith 1933). The beneficial outcome of dieting is commonly interpreted as an enhancement of inhibition by increasing the GABA/Glutamate ratio.…”

“…2022). Many of these studies focused on epilepsy, given the long‐established effect of ketogenic dieting or fasting as anticonvulsants (Helmholz and Keith 1933). The beneficial outcome of dieting is commonly interpreted as an enhancement of inhibition by increasing the GABA/Glutamate ratio.…”

Ketogenic Diet in Cancer Prevention and Therapy: Molecular Targets and Therapeutic Opportunities

“…In the 1920s and 1930s, all preliminary reports that verified the effectiveness of the ketogenic diet were retrospective reports [37,44,[61][62][63][64][65][66][67][68]. Unfortunately, some of these included a small number of patients and few clinical details and it was often not clear what should be regarded as a "good" or "partial" response to the ketogenic diet.…”

Pathophysiological Abnormalities in Migraine Ameliorated by Ketosis: A Proof-of-Concept Review

“…Even so, a study from 1967 has discovered how KBs could replace glucose as the major fuel of the brain in situations of prolonged fasting or glucose deficiency, being able to provide up to 60% of the energy needs of the brain [92]. Moreover, the impact of KBs on brain function were discovered much earlier in the 1920s, as it was observed that a low-carb and high-fat diet was successful in treating paediatric epilepsy [93,94]. While the human brain mainly relies on glucose as the primary energy source, other substrates might support metabolism also, for the most part when glucose stock is confined or insufficient [95].…”

Acute Supplementation of Beta‐Hydroxybutyrate Increases Visual Cortical Excitability in Humans: A Combined Electro‐EncephaloGraphy and Magnetic Resonance Spectroscopy Study

“…The number of studies measuring the impact of ketone supplementation or dieting on clinical populations and animal models is much larger, and their results are exceedingly heterogeneous (Machowiec et al 2022). Many of these studies focused on epilepsy, given the long-established effect of ketogenic dieting or fasting as anticonvulsants (Helmholz and Keith 1933). The beneficial outcome of dieting is commonly interpreted as an enhancement of inhibition by increasing the GABA/Glutamate ratio.…”

“…2022). Many of these studies focused on epilepsy, given the long‐established effect of ketogenic dieting or fasting as anticonvulsants (Helmholz and Keith 1933). The beneficial outcome of dieting is commonly interpreted as an enhancement of inhibition by increasing the GABA/Glutamate ratio.…”

Ketogenic Diet in Cancer Prevention and Therapy: Molecular Targets and Therapeutic Opportunities

“…In the 1920s and 1930s, all preliminary reports that verified the effectiveness of the ketogenic diet were retrospective reports [37,44,[61][62][63][64][65][66][67][68]. Unfortunately, some of these included a small number of patients and few clinical details and it was often not clear what should be regarded as a "good" or "partial" response to the ketogenic diet.…”

Pathophysiological Abnormalities in Migraine Ameliorated by Ketosis: A Proof-of-Concept Review

“…Even so, a study from 1967 has discovered how KBs could replace glucose as the major fuel of the brain in situations of prolonged fasting or glucose deficiency, being able to provide up to 60% of the energy needs of the brain [92]. Moreover, the impact of KBs on brain function were discovered much earlier in the 1920s, as it was observed that a low-carb and high-fat diet was successful in treating paediatric epilepsy [93,94]. While the human brain mainly relies on glucose as the primary energy source, other substrates might support metabolism also, for the most part when glucose stock is confined or insufficient [95].…”