Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome

Wilkinson, Michael J.; Manoogian, Emily N. C.; Zadourian, Adena; Lo, Hannah; Fakhouri, Savannah; Shoghi, Azarin; Wang, Xinran; Fleischer, Jason G.; Navlakha, Saket; Panda, Satchidananda; Taub, Pam R.

doi:10.1016/j.cmet.2019.11.004

Cited by 592 publications

(858 citation statements)

References 42 publications

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“…The health benefits of intermittent fasting on aging, antioxidant stress, metabolism and cardiovascular disease have been demonstrated in human and animal studies [18,[24][25][26][27], but its effect on gut microbiota remains largely unclear. In our study, we found 30 days of daily fasting (16 h fasting) led to significantly increased level of Akkermansia and deceased level of Alistipes.…”

Section: Discussionmentioning

confidence: 99%

The effects of daily fasting hours on shaping gut microbiota in mice

Li¹,

Su²,

Li³

et al. 2020

BMC Microbiol

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Background: It has recently been reported that intermittent fasting shapes the gut microbiota to benefit health, but this effect may be influenced to the exact fasting protocols. The purpose of this study was to assess the effects of different daily fasting hours on shaping the gut microbiota in mice. Healthy C57BL/6 J male mice were subjected to 12, 16 or 20 h fasting per day for 1 month, and then fed ad libitum for an extended month. Gut microbiota was analyzed by 16S rRNA gene-based sequencing and food intake was recorded as well.Results: We found that cumulative food intake was not changed in the group with 12 h daily fasting, but significantly decreased in the 16 and 20 h fasting groups. The composition of gut microbiota was altered by all these types of intermittent fasting. At genus level, 16 h fasting led to increased level of Akkermansia and decreased level of Alistipes, but these effects disappeared after the cessation of fasting. No taxonomic differences were identified in the other two groups. Conclusions: These data indicated that intermittent fasting shapes gut microbiota in healthy mice, and the length of daily fasting interval may influence the outcome of intermittent fasting.

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Section: Discussionmentioning

confidence: 99%

The effects of daily fasting hours on shaping gut microbiota in mice

Li¹,

Su²,

Li³

et al. 2020

BMC Microbiol

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“…In mice, TRF lowers blood cholesterol and sugar levels, reduces body weight, inflammation and dysbiosis, while increasing energy expenditure, motor control and endurance (Chaix et al, 2019b). Human studies confirmed TRE's potential as a healthpromoting intervention and showed that TRF can help improve a number of metabolic markers including weight, body fat, blood pressure, energy intake and endurance, in particular in individuals at risk for metabolic syndrome (Chaix et al, 2019b;Wilkinson et al, 2020). TRF is distinct from DR as its health benefits do not require a reduction in caloric intake.…”

Section: Introductionmentioning

confidence: 99%

Time-restricted feeding prolongs lifespan inDrosophilain a peripheral clock-dependent manner

Cabrera

Young

Axelrod

2020

Preprint

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Time-restricted feeding/eating (TRF/TRE) - limiting not the amount of food but the daily time window of food intake – is a dietary intervention that has been shown to improve health markers in model organisms and humans, but whether these benefits translate into positive effects on aging and longevity is not clear. We demonstrate here that TRF robustly prolongs lifespan in the short-lived genetically tractable model organism Drosophila melanogaster. Median TRF lifespan extensions range between ∼10% and ∼50% dependent on sex, reproductive status, TRF duration, and genotype. While TRF animals do not consume less food than ad libitum-fed (ALF) controls – making TRF distinct from dietary restriction – they still lose weight. TRF’s positive effect on longevity is at least in part dependent on a functioning circadian clock and is abolished in arrhythmic per0 and tim01 mutants as well as in constant light, suggesting that timed feeding acts as a zeitgeber partitioning eating and associated metabolic processes into certain phases of day and night. TRF-mediated longevity benefits are unaffected in flies whose neural circadian clocks have been abolished genetically, pointing towards peripheral clocks as the target of TRF mediating lifespan extension.

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“…Recently, dietary strategies that focus on the timing of eating and duration of fasting (i.e., chrono-nutrition), rather than the type, quality or quantity of foods, have been demonstrated to improve metabolic health independent of weight loss [12,13]. Specifically, time-restricted feeding (TRF, in which daily food intake is restricted to between 8-10 h) is a dietary strategy that has emerged as a practical intervention for weight loss, and improving insulin resistance along with other markers of whole-body health [10,[12][13][14][15][16]. Controlled (i.e., meals provided) 'early' TRF (eTRF; 0800-1500 h) improved both beta cell function in men with prediabetes [13] and 24-h glucose area under the curve (AUC) in individuals with obesity [12].…”

Section: Introductionmentioning

confidence: 99%

A Delayed Morning and Earlier Evening Time-Restricted Feeding Protocol for Improving Glycemic Control and Dietary Adherence in Men with Overweight/Obesity: A Randomized Controlled Trial

et al. 2020

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We determined the effects of time-restricted feeding (TRF; 8 h/d) versus extended feeding (EXF; 15 h/d) on 24-h and postprandial metabolism and subjective opinions of TRF in men with overweight/obesity. In a randomized crossover design, 11 sedentary males (age 38 ± 5 y; BMI: 32.2 ± 2.0 kg/m2) completed two isoenergetic diet protocols for 5 days, consuming meals at 1000, 1300 and 1700 h (TRF) or 0700, 1400 and 2100 h (EXF). On Day 5, participants remained in the laboratory for 24 h, and blood samples were collected at hourly (0700–2300 h) then 2-hourly (2300–0700 h) intervals for concentrations of glucose, insulin and appetite/incretin hormones. Structured qualitative interviews were conducted following completion of both dietary conditions and investigated thematically. Total 24-h area under the curve (AUCtotal) [glucose] tended to be lower for TRF versus EXF (−5.5 ± 9.0 mmol/L/h, p = 0.09). Nocturnal glucose AUC was lower in TRF (−4.2 ± 5.8 mmol/L/h, p = 0.04), with no difference in waking glucose AUC or AUCtotal for [insulin]. Attitudes towards TRF were positive with improved feelings of well-being. Barriers to TRF were work schedules, family commitments and social events. Compared to extended feeding, short-term TRF improved nocturnal glycemic control and was positively perceived in men with overweight/obesity.

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Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome

Cited by 592 publications

References 42 publications

The effects of daily fasting hours on shaping gut microbiota in mice

The effects of daily fasting hours on shaping gut microbiota in mice

Time-restricted feeding prolongs lifespan inDrosophilain a peripheral clock-dependent manner

A Delayed Morning and Earlier Evening Time-Restricted Feeding Protocol for Improving Glycemic Control and Dietary Adherence in Men with Overweight/Obesity: A Randomized Controlled Trial

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