Temporoparietal encoding of space and time during vestibular-guided orientation

Kaski, Diego; Quadir, Shamim; Nigmatullina, Yuliya; Malhotra, Paresh; Bronstein, Adolfo M.; Seemungal, Barry M.

doi:10.1093/brain/awv370

“…Although several brain regions are known to be involved in self-motion perception (Baier et al, 2013;Kaski et al, 2016;Nigmatullina et al, 2015), the insular and opercular cortices play an important role in multisensory integration of space-motion information for self-motion perception (Shinder & Newlands, 2014). These findings are consistent with reduced activity and connectivity of the PIVC, hippocampus and anterior insula observed in patients with CSD in a previous fMRI study (Indovina et al, 2015).…”

Section: Decreased Connectivity Of the Parieto-insularhippocampal-csupporting

confidence: 71%

“…The human vestibular cortex is centered in the OP2 region of the opercular cortices (zu Eulenburg et al, ) and together with adjacent areas of the insula and temporal‐parietal junction constitutes the human homologue of the parieto‐insular vestibular cortex (PIVC) that has been identified in other species (Eickhoff, Weiss, Amunts, Fink, & Zilles, ). Although several brain regions are known to be involved in self‐motion perception (Baier et al, ; Kaski et al, ; Nigmatullina et al, ), the insular and opercular cortices play an important role in multisensory integration of space‐motion information for self‐motion perception (Shinder & Newlands, ). These findings are consistent with reduced activity and connectivity of the PIVC, hippocampus and anterior insula observed in patients with CSD in a previous fMRI study (Indovina et al, ).…”

Section: Discussionmentioning

confidence: 99%

Altered brain function in persistent postural perceptual dizziness: A study on resting state functional connectivity

Lee

¹

,

Lee

²

,

Kim

³

et al. 2018

Human Brain Mapping

View full text Add to dashboard Cite

This study used resting state functional magnetic resonance imaging (rsfMRI) to investigate whole brain networks in patients with persistent postural perceptual dizziness (PPPD). We compared rsfMRI data from 38 patients with PPPD and 38 healthy controls using whole brain and region of interest analyses. We examined correlations among connectivity and clinical variables and tested the ability of a machine learning algorithm to classify subjects using rsfMRI results. Patients with PPPD showed: (a) increased connectivity of subcallosal cortex with left superior lateral occipital cortex and left middle frontal gyrus, (b) decreased connectivity of left hippocampus with bilateral central opercular cortices, left posterior opercular cortex, right insular cortex and cerebellum, and (c) decreased connectivity between right nucleus accumbens and anterior left temporal fusiform cortex. After controlling for anxiety and depression as covariates, patients with PPPD still showed decreased connectivity between left hippocampus and right inferior frontal gyrus, bilateral temporal lobes, bilateral insular cortices, bilateral central opercular cortex, left parietal opercular cortex, bilateral occipital lobes and cerebellum (bilateral lobules VI and V, and left I-IV). Dizziness handicap, anxiety, and depression correlated with connectivity in clinically meaningful brain regions. The machine learning algorithm correctly classified patients and controls with a sensitivity of 78.4%, specificity of 76.9%, and area under the curve = 0.88 using 11 connectivity parameters. Patients with PPPD showed reduced connectivity among the areas involved in multisensory vestibular processing and spatial cognition, but increased connectivity in networks linking visual and emotional processing. Connectivity patterns may become an imaging biomarker of PPPD.

show abstract

“…However, some authors have found normal path integration function with hippocampal lesions in humans but not rats (69). This conundrum has recently been solved by a recent human lesion study, which shows in fact that the important region is the temporoparietal junction (70). In addition, this study also found no impact of hippocampal lesions upon angular path integration function.…”

Section: The Vestibular Thalamic Projections and The Vestibular Cortimentioning

confidence: 99%

“…In addition, this study also found no impact of hippocampal lesions upon angular path integration function. It follows that dementia, which is more frequent in the elderly, may affect spatial orientation by its effect on vestibular cortical regions such as the TPJ (70). …”

Section: The Vestibular Thalamic Projections and The Vestibular Cortimentioning

confidence: 99%

Age-Related Vestibular Loss: Current Understanding and Future Research Directions

Allen

¹

,

Ribeiro

²

,

Arshad

³

et al. 2016

Self Cite

View full text Add to dashboard Cite

The vestibular system sub-serves a number of reflex and perceptual functions, comprising the peripheral apparatus, the vestibular nerve, the brainstem and cerebellar processing circuits, the thalamic relays, and the vestibular cerebral cortical network. This system provides signals of self-motion, important for gaze and postural control, and signals of traveled distance, for spatial orientation, especially in the dark. Current evidence suggests that certain aspects of this multi-faceted system may deteriorate with age and sometimes with severe consequences, such as falls. Often the deterioration in vestibular functioning relates to how the signal is processed by brain circuits rather than an impairment in the sensory transduction process. We review current data concerning age-related changes in the vestibular system, and how this may be important for clinicians dealing with balance disorders.

show abstract

“…In addition, this study also found no impact of hippocampal lesions upon angular path integration function. It follows that dementia, which is more frequent in the elderly, may affect spatial orientation by its effect on vestibular cortical regions such as the TPJ (70). Another currently unsolved question is the cortical location mediating the sensation of vertigo.…”

Section: The Vestibular Thalamic Projections and The Vestibular Cortimentioning

confidence: 99%

Age-Related Vestibular Loss: Current Understanding and Future Research Directions

Agrawal¹,

Carey²

2017

Frontiers Research Topics

0

View full text Add to dashboard Cite

The vestibular system sub-serves a number of reflex and perceptual functions, comprising the peripheral apparatus, the vestibular nerve, the brainstem and cerebellar processing circuits, the thalamic relays, and the vestibular cerebral cortical network. This system provides signals of self-motion, important for gaze and postural control, and signals of traveled distance, for spatial orientation, especially in the dark. Current evidence suggests that certain aspects of this multi-faceted system may deteriorate with age and sometimes with severe consequences, such as falls. Often the deterioration in vestibular functioning relates to how the signal is processed by brain circuits rather than an impairment in the sensory transduction process. We review current data concerning age-related changes in the vestibular system, and how this may be important for clinicians dealing with balance disorders.

show abstract

Temporoparietal encoding of space and time during vestibular-guided orientation

Cited by 73 publications

References 48 publications

Altered brain function in persistent postural perceptual dizziness: A study on resting state functional connectivity

Altered brain function in persistent postural perceptual dizziness: A study on resting state functional connectivity

Age-Related Vestibular Loss: Current Understanding and Future Research Directions

Age-Related Vestibular Loss: Current Understanding and Future Research Directions

Contact Info

Product

Resources

About