Temporal trends in urinary concentrations of phenols, phthalate metabolites and phthalate replacements between 2000 and 2017 in Boston, MA

Paternal and maternal preconception and maternal pregnancy urinary phthalate metabolite and BPA concentrations in relation to child behavior

“…Phthalate biomarker and BPA concentrations were measured over a 12-year period in our current study. Previous analysis of temporal trends of phthalate biomarkers and phenols in the EARTH study cohort show that their concentrations have generally declined (1–12 %) over this period ( Jiang et al, 2023 ). Assessing phthalates and BPA exposure is challenging because of their relatively short half-lives and the frequent and episodic nature of exposures ( Li, 2020 ; Radke et al, 2020 ; Ejaredar et al, 2017 ).…”

“…Our interest in paternal preconception exposures and children’s health was motivated by limited human and robust experimental animal evidence suggesting that both maternal and paternal preconception diet, stress, and chemical exposures can affect offspring health through histone modification, microRNAs, DNA methylation, and DNA-associated proteins in sperm ( Xu et al, 2021 ; Watkins, 2018 ; Mychasiuk et al, 2013 ; Rando, 2012 ; Rando and Simmons, 2015 ; Chan et al, 2018 ; Rodgers et al, 2015 ; Braun et al, 2017 ; Braun et al, 2013 ; Daxinger and Whitelaw, 2012 ; Kumar et al, 2013 ; Yehuda, 2011 ; Huypens, 2016 ; Oluwayiose, 2022 ; Marcho et al, 2020 ; Lien, 2015 ; Colicino, 2021 ; Daniel, 2020 ; Engel, 2010 ; Kobrosly, 2014 ; Engel et al, 2018 ; Hyland et al, 2019 ; Ejaredar et al, 2017 ; Mustieles and Fernández, 2020 ; Casas, 2015 ; Braun, 2009 ; Braun, 2011 ; Braun et al, 2017 ; Jiang et al, 2023 ). Our study found evidence to suggest that there are relationships of some preconception maternal and paternal urinary phthalate metabolites concentrations with neurobehavior in school-aged children.…”

PPARα Senses Bisphenol S to Trigger EP300-Mediated Autophagy Blockage and Hepatic Steatosis

“…7 The urinary BPS concentration increased by 50% (from 0.23 ng/ mL to 0.35 ng/mL) during the last two decades in Boston, since the restriction of BPA. 8 The concentration of urinary BPS was significantly higher than the other alternatives, in various countries, such as China, 9,10 Japan, 11 and Sweden. 12 Until 2012, the highest geometric mean concentration of urinary BPS in populations was found in Japan (1.18 ng/mL), followed by the United States (0.299 ng/mL) and China (0.226 ng/mL).…”

“…It is of concern that the exposure dose of BPS in the human body is gradually increasing . The urinary BPS concentration increased by 50% (from 0.23 ng/mL to 0.35 ng/mL) during the last two decades in Boston, since the restriction of BPA . The concentration of urinary BPS was significantly higher than the other alternatives, in various countries, such as China, , Japan, and Sweden .…”

The adverse role of endocrine disrupting chemicals in the reproductive system

“…Exposure to EDCs has been observed to reduce the number of functional follicles in the ovary by activating specific signaling pathways, disrupting intercellular communication between oocytes and granulosa cells, and inducing oxidative stress. These effects ultimately result in DOR and have long-lasting detrimental impacts on reproductive function ( 123 , 144 ). However, a study conducted on women attending a fertility clinic found no association between mixtures of phenols and PAE metabolites in urine and ovarian reserve ( 145 ).…”