Temporal global expression profiling of DSS colitis and identification of potential targets of ulcerative colitis

Fang, Kai; Bruce, Megan; Pattillo, Christopher B.; Bao, Jianxiong; Zhang, S; Stone, Randolph; Clifford, John Noel; Kevil, Christopher G.

doi:10.1097/00054725-200912002-00147

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“…By analyzing the publicly published mRNA expression profiles, we determined that Ninj1 mRNA expression was greater in colon tissues from patients with CD (n = 10) and UC (n = 10), as compared to normal controls (n = 11) ( Figure 1A) [31]. Moreover, Ninj1 mRNA expression was upregulated in the colon of dextran sodium sulfate (DSS)-treated mice, when compared to untreated (normal) mice ( Figure 1B) [32]. We further validated Ninj1 expression in mice colon tissues by Western blot analysis.…”

Section: Ninj1 Expression Increases Under Intestinal Inflammatory Conmentioning

confidence: 99%

Detrimental Role of Nerve Injury-Induced Protein 1 in Myeloid Cells under Intestinal Inflammatory Conditions

Jung

Kang

Pak

et al. 2020

IJMS

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Nerve injury-induced protein 1 (Ninjurin1, Ninj1) is a cell-surface adhesion molecule that regulates cell migration and attachment. This study demonstrates the increase in Ninj1 protein expression during development of intestinal inflammation. Ninj1-deficient mice exhibited significantly attenuated bodyweight loss, shortening of colon length, intestinal inflammation, and lesser pathological lesions than wild-type mice. Although more severe inflammation and serious lesions are observed in wild-type mice than Ninj1-deficient mice, there were no changes in the numbers of infiltrating macrophages in the inflamed tissues obtained from WT and Ninj1-deficient mice. Ninj1 expression results in activation of macrophages, and these activated macrophages secrete more cytokines and chemokines than Ninj1-deficient macrophages. Moreover, mice with conditional deletion of Ninj1 in myeloid cells (Ninj1fl/fl; Lyz-Cre+) alleviated experimental colitis compared with wild-type mice. In summary, we propose that the Ninj1 in myeloid cells play a pivotal function in intestinal inflammatory conditions.

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Section: Ninj1 Expression Increases Under Intestinal Inflammatory Conmentioning

confidence: 99%

Detrimental Role of Nerve Injury-Induced Protein 1 in Myeloid Cells under Intestinal Inflammatory Conditions

Jung

Kang

Pak

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

Temporal global expression profiling of DSS colitis and identification of potential targets of ulcerative colitis

Cited by 1 publication

References 0 publications

Detrimental Role of Nerve Injury-Induced Protein 1 in Myeloid Cells under Intestinal Inflammatory Conditions

Detrimental Role of Nerve Injury-Induced Protein 1 in Myeloid Cells under Intestinal Inflammatory Conditions

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