2019
DOI: 10.1038/s41598-019-56233-0
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Abstract: Human microbiomes are predicted to assemble in a reproducible and ordered manner yet there is limited knowledge on the development of the complex bacterial communities that constitute the oral microbiome. The oral microbiome plays major roles in many oral diseases including early childhood caries (ECC), which afflicts up to 70% of children in some countries. Saliva contains oral bacteria that are indicative of the whole oral microbiome and may have the ability to reflect the dysbiosis in supragingival plaque c… Show more

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Cited by 70 publications
(84 citation statements)
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“…Strains that were identified belong to genera that have been shown to be part of the buccal core microbiota during early life. A recent study by Daspher and colleges has shown that members of Streptococcus, Staphylococcus and Rothia genera were early life colonizers of the BC [39]. In our library, Enterococcus species were also present.…”
Section: Discussionsupporting
confidence: 53%
“…Strains that were identified belong to genera that have been shown to be part of the buccal core microbiota during early life. A recent study by Daspher and colleges has shown that members of Streptococcus, Staphylococcus and Rothia genera were early life colonizers of the BC [39]. In our library, Enterococcus species were also present.…”
Section: Discussionsupporting
confidence: 53%
“…For instance, a recent publication on an Australian cohort of 134 children was followed from 2 months until 4 years of age demonstrated the potential of salivary microbiome in predicting the development of early childhood caries. 11…”
Section: Cohort Studiesmentioning
confidence: 99%
“…Differences in operational taxonomic units of bacterial genera belonging to the Firmicutes phylum were already described between a group of children fed with breast milk and a group fed with formula, combined or not with breast milk (44). In addition, when the oral microbiome data were compared with ECC development, Streptococcus mutans was identified as the most discriminatory taxa associated with disease (45), and their levels could be a surrogate marker for frequent sugar intake by children. High sugar exposure leads to dysbiosis of the dental biofilm microbiota, resulting in acidogenic and aciduric bacteria (20,45).…”
Section: Discussionmentioning
confidence: 86%
“…In addition, when the oral microbiome data were compared with ECC development, Streptococcus mutans was identified as the most discriminatory taxa associated with disease (45), and their levels could be a surrogate marker for frequent sugar intake by children. High sugar exposure leads to dysbiosis of the dental biofilm microbiota, resulting in acidogenic and aciduric bacteria (20,45).…”
Section: Discussionmentioning
confidence: 99%