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citations
Cited by 335 publications
(279 citation statements)
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References 18 publications
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“…Although the confidence intervals for these estimates are narrower for olanzapine (with observations from 29 pregnancies) than for clozapine (with observations from four pregnancies only) it is interesting to note that both these drugs have a metabolism largely dependent on CYP1A2,13 an enzyme that has been shown to have a decreased activity during the second and third trimesters 6, 18. This could explain why our results for these drugs may differ from the others.…”
Section: Discussionmentioning
confidence: 64%
“…Although the confidence intervals for these estimates are narrower for olanzapine (with observations from 29 pregnancies) than for clozapine (with observations from four pregnancies only) it is interesting to note that both these drugs have a metabolism largely dependent on CYP1A2,13 an enzyme that has been shown to have a decreased activity during the second and third trimesters 6, 18. This could explain why our results for these drugs may differ from the others.…”
Section: Discussionmentioning
confidence: 64%
“…It may be that the increased risk of spontaneous miscarriages found in the studies discussed above [10,21] was due to decreased caffeine metabolism among these women and the subsequent fetal concentrations of this xenobiotic. However results from another study found that neither estrogen nor progesterone altered CYP1A2 levels in 35 pregnant women [41]. In this current study, women who experienced nausea and vomiting in pregnancy did not have significantly increased odds of having a slow caffeine metabolism after adjusting for smoking, alcohol, caffeine intake, mothers age and body mass index.…”
Section: Nausea and Vomiting In Pregnancy Fetal Growth Restriction Amentioning
confidence: 49%
“…A positive linear trend between this cumulative dose and EDDP/methadone ratios in hair was observed [64]. This could illustrate auto-induction of methadone metabolism, mainly mediated by CYP3A4 [65], or, again, elevated CYP450 activity during pregnancy [61][62][63]. These studies suggest that applying segmental hair analysis to retrospectively assess drug metabolism may hold promise as an alternative phenotyping approach.…”
Section: Hairmentioning
confidence: 72%
“…Citalopram/norcitalopram ratios in hair segments corresponding to the first and third trimester of pregnancy were significantly lower than ratios in the postpartum period [59]. Although only 4 women were included, these findings could confirm the elevated metabolism of citalopram [60] and increased CYP2D6 activity during pregnancy [61][62][63].…”
Section: Hairmentioning
confidence: 79%
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