Temporal and geographical variations in colorectal cancer incidence in Northern Iran 2004–2013

Hasanpour-Heidari, Susan; Fazel, Abdolreza; Semnani, S H; Khandoozi, Seyyedreza; Amiriani, Taghi; Sedaghat, Seyed Mehdi; Hosseinpoor, Reza; Azarhoush, R; Poorabbasi, Mohammad; Naeimi-Tabiei, Mohammad; Roshandel, Gholamreza; Bray, Freddie; Weiderpass, Elisabete

doi:10.1016/j.canep.2019.02.003

Cited by 24 publications

(25 citation statements)

References 20 publications

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“…Furthermore, it was surprisingly shown that colorectal cancer incidence was higher in women than men in 2016. This higher incidence shows a sex transition in the incidence pattern of this cancer in Iran [24,31]. We found that Mazandaran, Gilan, and Boushehr had high ASR in colorectal cancer in proportion to their all cancer types' ASR (Figures 3 and 4).…”

Section: Colorectal Cancermentioning

confidence: 71%

National and Subnational Cancer Incidence for 22 Cancer Groups, 2000 to 2016: A Study Based on Cancer Registration Data of Iran

Khanali

Kolahi

2021

Journal of Cancer Epidemiology

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Background. Cancer is an increasing public health concern, and detailed knowledge of the cancer incidence is required for developing effective cancer control plans. The objective of this study is to present the cancer incidence of 22 cancer groups in Iran and all 31 provinces of the country from 2000 to 2016, for both sexes across different age groups. Method. To study the national and provincial cancer incidence in Iran, we extracted data from the Cancer Project, which collects the Iranian cancer registry data and visualizes it in the VIZIT data visualization system. The methodology and statistical analysis that is used in this study follow the cancer project study protocol. Joinpoint analysis was performed to calculate the average annual percent change of the crude rates and age-standardized rates from 2000 to 2016. Results. Cancer incidence was 126,982 patients in 2016, and the crude rate (CR) of cancer in both sexes and all ages was 155 per 100,000 people. Cancer incidence approximately doubled between 2000 and 2016; however, the age-standardized rate (ASR) had a less drastic increase. The most incident cancers in 2016 were breast, skin, and colorectal cancers; however, the ranking of cancer groups by incidence was different in different age and sex groups and provinces. Some cancers exhibited a unique distribution pattern in the country with high-incidence local areas. Discussion. The study showed that cancer incidence, crude rate, and age-standardized rate (ASR) in Iran had increased in 2000-2016 with vast heterogeneity by cancer type, province, and sex. Moreover, it was shown that the crude rate of cancer in Iran was much less than the global cancer crude rate. Providing such data helps to allocate resources and develop effective national cancer control plans appropriately.

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Section: Colorectal Cancermentioning

confidence: 71%

National and Subnational Cancer Incidence for 22 Cancer Groups, 2000 to 2016: A Study Based on Cancer Registration Data of Iran

Khanali

Kolahi

2021

Journal of Cancer Epidemiology

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“…(2,4) In Iran there was an increase in the agestandardized incidence rates (ASRs) for CRC in 2012-2015, and their incidence is moving in an upward manner. (5)(6)(7) In East Azerbaijan province CRC is the second most common cancer in both sexes, with an overall incidence rate of 20.2 and 16.2 per 100000 respectively in men and women. (8) East Azerbaijan province has the 4 th place among Iran's provinces when it comes to CRC ASRs, and is the only province in North/Northwest Iran with an ASR higher than 20 (ASR= 20.77).…”

Section: Introductionmentioning

confidence: 99%

Epidemiological aspects of colorectal cancer in East Azerbaijan, Northwest Iran: five year survival analysis

et al. 2021

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BackgroundColorectal cancer (CRC) is the third most common cancer and the second leading cause of death from cancer in the world. Currently, CRC is the fourth most common cancer in men and the second common cancer in women of all ages in Iran. The aim of this study was to determine the epidemiologic profile of CRC along with CRC specific survival analysis. MethodsThis was an analytical cross-sectional study using the East Azerbaijan Population Based Cancer Registry database (EA-PBCR) as a source for data related to patients with a diagnosis of CRC. Colorectal cancer specific 1- to 5-year survival analysis and mortality rates were calculated. Log-rank test and Cox regression analysis was performed to test the equality of survival function and mortality hazard. ResultsA total of 2,366 newly diagnosed CRCs were registered during 3 years, with a male: female ratio of 1.31. Overall survival rate was 49.8%. One- to 5-year survival rates were 96.21%, 56.94%, 48.62%, 47.88% and 46.76% respectively. At multivariate level, after adjusting for all variables, regression analysis showed that the hazard of mortality in stage IV cancers was 46.44 times higher than that in stage I cancers (HR=46.44, 95% CI: 14.86-145.14, p=0.000). However, differences in patients’ age group and sex and the subsite of cancer did not create any statistically significant variation between groups in regards to mortality hazards (p>0.05). ConclusionThis study demonstrated that the stage and grade of CRC were important prognostic factors and that early screening and diagnosis of CRC were essential.

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“…This was not surprising, because they are the most common cancers in the Golestan population. [13][14][15]24,25 According to the latest GPCR report (unpublished data), cancers of the breast (female), stomach, colorectum, lung and esophagus were the most common malignancies in the Golestan population in 2017 (Table S1, Supplementary file 1).…”

Section: Discussionmentioning

confidence: 99%

Building a Cancer Biobank in a Low-Resource Setting in Northern Iran: the Golestan Cancer Biobank

et al. 2021

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Background:We aim to present the development and the initial results of the Golestan Cancer Biobank (GoCB), in a low resource setting in northern Iran. Methods: The GoCB protocol and its standard operation procedures (SOP) were developed according to internationally accepted standards and protocols with some modifications considering the limited resources in our setting. The main biological samples collected by the GoCB include blood sample, urine sample, fresh endoscopy tissue sample, fresh surgical tissue sample and formalin fixed paraffin embedded (FFPE) tissue sample. The GoCB collects patients' demographic data, tumor characteristics as well as data on risk factors. We developed a specific GoCB software for management of patient data and biological sample information. The GoCB dataset is annually linked with the Golestan cancer registry dataset to add complementary data (e.g., survival data). Results: The GoCB started collection of data and biological samples in December 2016. By November 2020, a total number of 1217 cancer patients participated in the GoCB. The majority of the GoCB participants (n = 942, 77%) were those with gastrointestinal and breast cancers. Data on risk factors were successfully collected in 684 (56.2%) of the participants. Overall, 3563 samples were collected from the GoCB participants and 730 samples were used in 7 national and international research projects. Conclusion: We considered specific strategies to overcome major limitations, especially budget shortage, in the development and maintenance of a cancer-specific biological repositories in our setting. The GoCB may be considered as a model for the development of biobank in low-and middle-income countries (LMICs).

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Temporal and geographical variations in colorectal cancer incidence in Northern Iran 2004–2013

Cited by 24 publications

References 20 publications

National and Subnational Cancer Incidence for 22 Cancer Groups, 2000 to 2016: A Study Based on Cancer Registration Data of Iran

National and Subnational Cancer Incidence for 22 Cancer Groups, 2000 to 2016: A Study Based on Cancer Registration Data of Iran

Epidemiological aspects of colorectal cancer in East Azerbaijan, Northwest Iran: five year survival analysis

Building a Cancer Biobank in a Low-Resource Setting in Northern Iran: the Golestan Cancer Biobank

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