Temporal and dose-dependent differences in simultaneously-induced cocaine hypervigilance and conditioned-place-preference in marmoset monkeys

Borges, Aline Caron; Duarte, Renata B.; Nogueira, Luma de Lira; Barros, Marília

doi:10.1016/j.drugalcdep.2015.01.007

Cited by 8 publications

(7 citation statements)

References 45 publications

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“…Conditioned place preference (CPP) was developed as a technique to assess the reinforcing properties of opioid drugs (Rossi and Reid, 1976 ; Katz and Gormezano, 1979 ; Mucha and Iversen, 1984 ). Now, CPP is widely used to test context associations based on the rewarding properties of an unconditioned stimulus in many organisms including, rodents (Lu et al, 2005 ; Akbarabadi et al, 2018 ; Cunningham, 2019 ), flies (Kaun et al, 2011 ), C. elegans (Musselman et al, 2012 ; Engleman et al, 2018 ), planaria (Hutchinson et al, 2015 ; Mohammed Jawad et al, 2018 ; Adams and Byrne, 2019 ; Phelps et al, 2019 ), primates (Wang et al, 2012 ; Borges et al, 2015 ; Yan et al, 2015 ; Wu et al, 2016 ), and humans (Thewissen et al, 2006 ; Childs and De Wit, 2009 , 2013 , 2016 ). Although a widely used behavioral model, CPP is a complex behavior that incorporates Pavlovian learning, memory, and motivated behaviors.…”

Section: Introductionmentioning

confidence: 99%

Drug-Induced Conditioned Place Preference and Its Practical Use in Substance Use Disorder Research

McKendrick

Graziane

2020

Front. Behav. Neurosci.

108

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The conditioned place preference (CPP) paradigm is a well-established model utilized to study the role of context associations in reward-related behaviors, including both natural rewards and drugs of abuse. In this review article, we discuss the basic history, various uses, and considerations that are tied to this technique. There are many potential takeaway implications of this model, including negative affective states, conditioned drug effects, memory, and motivation, which are all considered here. We also discuss the neurobiology of CPP including relevant brain regions, molecular signaling cascades, and neuromodulatory systems. We further examine some of our prior findings and how they integrate CPP with self-administration paradigms. Overall, by describing the fundamentals of CPP, findings from the past few decades, and implications of using CPP as a research paradigm, we have endeavored to support the case that the CPP method is specifically advantageous for studying the role of a form of Pavlovian learning that associates drug use with the surrounding environment.

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Section: Introductionmentioning

confidence: 99%

Drug-Induced Conditioned Place Preference and Its Practical Use in Substance Use Disorder Research

McKendrick

Graziane

2020

Front. Behav. Neurosci.

108

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“…We tested whether sphingolipid rheostat controlling enzymes would respond to recent cocaine exposure and CPP learning and consolidation/abstinence in a translational approach in monkeys, thereby getting closer to the human condition. We established a cocaine CPP in monkeys as previously reported 23,24 . The CPP establishment went along with a decline in blood ASM, but not NSM activity.…”

Section: Discussionmentioning

confidence: 72%

“…Conditioned place preference (CPP) was established and tested in a two‐compartment rectangular CPP box (120 × 60 × 35 cm) as previously described 23,24 (for details, see Supporting Information).…”

Section: Methodsmentioning

confidence: 99%

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Cocaine attenuates acid sphingomyelinase activity during establishment of addiction‐related behavior—A translational study in rats and monkeys

et al. 2020

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Cocaine addiction is a severe psychiatric condition for which currently no effective pharmacotherapy is available. Brain mechanisms for the establishment of addiction‐related behaviors are still not fully understood, and specific biomarkers for cocaine use are not available. Sphingolipids are major membrane lipids, which shape neuronal membrane composition and dynamics in the brain. Here, we investigated how chronic cocaine exposure during establishment of addiction‐related behaviors affects the activity of the sphingolipid rheostat controlling enzymes in the brain of rats. As we detected specific effects on several enzymes in the brain, we tested whether the activity of selected enzymes in the blood may serve as potential biomarker for cocaine exposure in non‐human primates (Callithrix penicillata). We found that intravenous cocaine self‐administration led to a reduced mRNA expression of Cers1, Degs1 and Degs2, and Smpd1 in the prefrontal cortex of rats, as well as a reduction of Cers4 expression in the striatum. These effects reversed after 10 days of abstinence. Monkeys showed a robust cocaine‐induced place preference (CPP). This coincided with a reduction in blood acid sphingomyelinase (ASM) activity after CPP establishment. This effect normalized after 15 days of abstinence. Altogether, these findings suggest that the establishment of cocaine addiction‐related behaviors coincides with changes in the activity of sphingolipid controlling enzymes. In particular, blood ASM levels may serve as a translational biomarker for recent cocaine exposure.

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“…The statistical package PRIZM 6 was used for the data analysis. Analyses for the CPP were conducted by comparison of the test trials with the pre-CPP levels seen on the last habituation trial (H2) [ 25 ]. The preference scores were calculated as follows: [post-test: duration of visits in the METH-paired room/(duration of visits in the METH-paired room+duration in the saline-paired room)]–[habituation day2 (pre-test): duration of visits in the METH-paired room/(duration of visits in the METH-paired room+duration in the saline-paired room)].…”

Section: Methodsmentioning

confidence: 99%

Claustral MeCP2 Regulates Methamphetamine-induced Conditioned Place Preference in Cynomolgus Monkey

et al. 2022

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The claustrum, a brain nucleus located between the cortex and the striatum, has recently been highlighted in drug-related reward processing. Methyl CpG-binding protein-2 (MeCP2) is a transcriptional regulator that represses or activates the expression of the target gene and has been known to have an important role in the regulation of drug addiction in the dopaminergic reward system. The claustrum is an important region for regulating reward processing where most neurons receive dopamine input; additionally, in this region, MeCP2 is also abundantly expressed. Therefore, here, we hypothesized that MeCP2 would be involved in drug addiction control in the Claustrum as well and investigated how claustral MeCP2 regulates drug addiction. To better understand the function of human claustral MeCP2, we established a non-human primate model of methamphetamine (METH) - induced conditioned place preference (CPP). After a habituation of two days and conditioning of ten days, the CPP test was conducted for three days. Interestingly, we confirmed that virus-mediated overexpression of MECP2 in the claustrum showed a significant reduction of METH-induced CPP in the three consecutive days during the testing period. Moreover, they showed a decrease in visit scores (frequency for visit) for the METH-paired room compared to the control group although the scores were statistically marginal. Taken together, we suggest that the claustrum is an important brain region associated with drug addiction, in which MeCP2 may function as a mediator in regulating the response to addictive drugs.

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Temporal and dose-dependent differences in simultaneously-induced cocaine hypervigilance and conditioned-place-preference in marmoset monkeys

Cited by 8 publications

References 45 publications

Drug-Induced Conditioned Place Preference and Its Practical Use in Substance Use Disorder Research

Drug-Induced Conditioned Place Preference and Its Practical Use in Substance Use Disorder Research

Cocaine attenuates acid sphingomyelinase activity during establishment of addiction‐related behavior—A translational study in rats and monkeys

Claustral MeCP2 Regulates Methamphetamine-induced Conditioned Place Preference in Cynomolgus Monkey

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