TEMPO oxidized nano-cellulose containing thermo-responsive injectable hydrogel for post-surgical peritoneal tissue adhesion prevention

Sultana, Tamanna; Hải, Hồ Văn Minh; Abueva, Celine; Kang, Hoe Jin; Lee, Sun-Young; Lee, Byong‐Taek

doi:10.1016/j.msec.2019.03.110

Cited by 47 publications

(25 citation statements)

References 53 publications

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“…21 Previous studies also showed that inclusion of TOCNF in hydrogel systems facilitated cell growth and improved biocompatibility in vitro. 16–18…”

Section: Resultsmentioning

confidence: 99%

“…Earlier studies have shown that TOCNF provides high crystallinity and is capable of making hydrogels in a three-dimensional environment for cell attachment and proliferation. 16–18 In the present study, TEMPO treatment is limited to CNF only because CNC has already achieved high crystallinity due to acid hydrolysis.…”

Section: Introductionmentioning

confidence: 99%

“…16,19 Only few studies demonstrated the biocompatibility of pure CNC, CNF, or TOCNF and mainly limited to in vitro investigations. 16,17,19–21 To the best of our knowledge, the systematic in vivo biological evaluation of CNC, CNF, or TOCNF has not been clarified thus far.…”

Section: Introductionmentioning

confidence: 99%

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Preliminary studies on the in vivo performance of various kinds of nanocellulose for biomedical applications

Makkar

Padalhin

et al. 2019

J Biomater Appl

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Nanocellulose has recently attracted a great deal of attention for numerous biomedical applications due to its superior mechanical properties, high surface area, tailorable surface chemistry, good biocompatibility, renewable nature, and cost-effectiveness. The objective of this study was to investigate the long-term in vivo biocompatibility of three kinds of nanocellulose, namely, cellulose nanocrystal (CNC), cellulose nanofiber (CNF), and TEMPO-oxidized cellulose nanofiber (TOCNF). The morphological features of these nanocellulose materials were examined by transmission electron microscopy. In vivo biocompatibility of all nanocellulose materials was investigated using a subcutaneous rat model for 1, 2, 4, and 12 weeks of implantation. The average diameters of prepared homogenous CNC, CNF, and TOCNF were ∼6 nm, ∼8 nm, and ∼5 nm respectively, as depicted by micrographs obtained by using transmission electron microscopy. TOCNF showed highest in vitro biocompatibility with respect to CNC and CNF in response to L929 fibroblast cells. In vivo studies revealed that all nanocellulose materials exhibited no foreign body reaction up to two-week post-injection. Subcutaneous implantation at 12 weeks showed lowest inflammation and better tissue repair for TOCNF compared to CNC and CNF. The results suggest that the long-term biocompatibility profile follows the sequence: TOCNF > CNC > CNF.

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“…21 Previous studies also showed that inclusion of TOCNF in hydrogel systems facilitated cell growth and improved biocompatibility in vitro. 16–18…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preliminary studies on the in vivo performance of various kinds of nanocellulose for biomedical applications

Makkar

Padalhin

et al. 2019

J Biomater Appl

Self Cite

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show abstract

“…In addition to thermosensitive behavior of this type of hydrogel, there was good cell availability (>50% after 14 days of treatment) of L929 and RBMSCs cells. [ 46 ]…”

Section: Tempo‐oxidized Cellulosementioning

confidence: 99%

Antimicrobial and Wound Treatment Aspects of Micro‐ and Nanoformulations of Carboxymethyl, Dialdehyde, and TEMPO‐Oxidized Derivatives of Cellulose: Recent Advances

Alavi

Nokhodchi

2020

Macromolecular Bioscience

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/mabi.201900362.The remedy for infected chronic wounds such as diabetic foot ulcers is more complicated particularly in the case of patients with an inefficient immune system. Also, fighting against microbial infections in the wound site by available antibiotics may not be effective because of emerging antibiotic resistance properties among pathogenic bacteria and fungi. Recently, applications of micro-and nanoformulations of biomaterials have demonstrated improved therapeutic abilities for wound dressings. In this way, carboxymethyl, dialdehyde, and 2,2,6,6-tetramethylpiperidine-1-oxyl-oxidized celluloses are common biomaterials having outstanding physicochemical and therapeutic properties compared to unmodified cellulose. Therefore, in this review, recent progress in the field of wound healing and antimicrobial activities of these derivatives are presented and discussed.

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“…By contrast, physical hydrogels such as thermo‐responsive ones converted from liquid form to gel form at body temperature eliminate the need for chemical reaction or ultraviolet irradiation in vivo. [ 31–33 ] But minutes of waiting time still has to be allowed for the physical gels to solidify. With the problems above associating with the applying processes, current physical barriers remained under‐performed and can only alleviate or reduce adhesions to some extent.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Zwitterionic Cream Gel for Effective Prevention of Postoperative Adhesion

Zhang

Yang

Wang

et al. 2020

Adv Funct Materials

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Postoperative peritoneal adhesions are frequent complications for almost any type of abdominal and pelvic surgery. This leads to numerous medical problems and a huge financial burden to the patients. Current anti‐adhesion strategies focus mostly on physical barriers including films and hydrogels. However, they can only alleviate or reduce adhesions to a certain level and their applying processes are far from ideal. This work reported the development of a biodegradable zwitterionic cream gel presenting a series of characters for an ideal anti‐adhesion material, including unique injectable yet malleable and self‐supporting properties, which enables an instant topical application, no curing, waiting, or suturing, no hemostasis requirement, protein/cell resistance, and biodegradability. The cream gel shows a major advancement in anti‐adhesion efficacy by completely and reliably preventing a primary and more severe recurrent adhesion in rat models.

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TEMPO oxidized nano-cellulose containing thermo-responsive injectable hydrogel for post-surgical peritoneal tissue adhesion prevention

Cited by 47 publications

References 53 publications

Preliminary studies on the in vivo performance of various kinds of nanocellulose for biomedical applications

Preliminary studies on the in vivo performance of various kinds of nanocellulose for biomedical applications

Antimicrobial and Wound Treatment Aspects of Micro‐ and Nanoformulations of Carboxymethyl, Dialdehyde, and TEMPO‐Oxidized Derivatives of Cellulose: Recent Advances

Biodegradable Zwitterionic Cream Gel for Effective Prevention of Postoperative Adhesion

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