Templated high density lipoprotein nanoparticles as potential therapies and for molecular delivery

Green design “bioinspired disassembly-reassembly strategy” applied for improved tumor-targeted anticancer drug delivery

“…They form core-shell spherical or discoidal nanoparticles of 7-600 nm in vivo to transport waterinsoluble lipids for peripheral usage [16,17]. Structurally, the amphiphilic nature of the lipids is capable of stabilizing the lipophilic cores, while the anchored apolipoproteins maintain the hydrodynamic size of the self-assembled natural nanoparticles [18,19]. Furthermore, lipoproteins possess specific affinity to their endogenous receptors in vivo.…”

Hyaluronic acid-decorated reconstituted high density lipoprotein targeting atherosclerotic lesions

“…Reconstituted HDL (rHDL), the synthetic form of endogenous HDL, is mostly composed of natural or synthetic phospholipids, apos, triglycerides, free cholesterol and cholesterol esters, etc. Recently, rHDL has been not only demonstrated as similar physicochemical properties to native counterpart, but also extensively applied in pharmaceutical development as effective drug delivery system [9]. Among them, our previous studies have successfully constructed rHDL loaded with cardiovascular drug tanshinone IIA (TA) [10e12].…”

Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

“…233 The SR-B1 is broadly overexpressed among various cancer cells including HCC and SR-B1 receptor-mediated HDL uptake makes HDL a promising target delivery vehicle for therapeutics. 234 The rHDL was utilized as a biomimetic nanovector by Ding et al, 235 mediating HCC-targeted cholesterol-conjugated siRNA (Chol-siRNA) delivery. rHDL could enhance cellular uptake and in vitro cytotoxicity of the siRNA and specifically target it into cytoplasm.…”