1997
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Abstract: The synthesis of oligoguanylates [oligo(G)s] is catalyzed by a template of oligocytidylates [oligo(C)s] containing 2',5'- and 3',5'-linked phosphodiester bonds with and without incorporated C5'ppC groupings. An oligo(C) template containing exclusively 2',5'-phosphodiester bonds also serves as a template for the synthesis of complementary oligo(G)s. The oligo(C) template was prepared by the condensation of the 5'-phosphorimidazolide of cytidine on montmorillonite clay. These studies establish that RNA oligomers… Show more

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Cited by 94 publications
(68 citation statements)
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References 35 publications
(68 reference statements)
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“…Different solutions for the origin of abiotically obtained RNA polymers have been proposed and reviewed [99][100][101] and conditions for the promotion of their polymerization have been defined [102,103]. The actual prebiotic relevance of several of these solutions was criticized [97], due to their requirement for highly activated precursors whose formation entails complex chemistry.…”
Section: Abiotic Rnamentioning
confidence: 99%
“…Different solutions for the origin of abiotically obtained RNA polymers have been proposed and reviewed [99][100][101] and conditions for the promotion of their polymerization have been defined [102,103]. The actual prebiotic relevance of several of these solutions was criticized [97], due to their requirement for highly activated precursors whose formation entails complex chemistry.…”
Section: Abiotic Rnamentioning
confidence: 99%
“…The ability of RNA to catalyze reactions is exemplified by natural and artificial ribozymes that promote a wide variety of chemical reactions (4) as well as the observation that the catalytic core of the ribosome is comprised of RNA (5). Despite the attractiveness of the RNA world as a hypothetical stage of early life, it remains unclear how RNA [or a predecessor of RNA (6-11)] would initially have been synthesized without the aid of protein enzyme catalysis.Several distinct proposals have been presented for the abiotic origin of the first RNA polymers (10,(12)(13)(14)(15)(16)(17). Perhaps the most notable is that of Ferris and coworkers, in which mineral surfaces are used to locally concentrate and promote the polymerization of ligation-activated mononucleotides, an approach that allows formation of single-stranded RNA strands up to ca.…”
mentioning
confidence: 99%
“…Several distinct proposals have been presented for the abiotic origin of the first RNA polymers (10,(12)(13)(14)(15)(16)(17). Perhaps the most notable is that of Ferris and coworkers, in which mineral surfaces are used to locally concentrate and promote the polymerization of ligation-activated mononucleotides, an approach that allows formation of single-stranded RNA strands up to ca.…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…Because of their high surface areas and adsorption characteristics, clays have long been postulated to play a key role in concentrating the products of nonbiological organic chemical processes leading to the Huxley-Darwin-Oparin-Haldane model for the origin of living systems [32][33] . Clays can also act as catalysts for the formation of RNA oligomers from activated nucleotide precursors [34][35] . Furthermore, montmorillonite clay and alumina both catalyse polymerisation of amino acids in peptide formation reactions such as those of glycine, alanine, leucine, valine and proline [36][37][38][39][40][41] .…”
Section: Introductionmentioning
confidence: 99%