Temperature-responsive copolymer brush constructed on a silica microparticle by atom transfer radical polymerization

Nomura, Kouji; Makino, Hirokazu; Nakaji-Hirabayashi, Tadashi; Kitano, Hiromi; Ohno, Kohji

doi:10.1007/s00396-014-3476-5

Cited by 9 publications

(5 citation statements)

References 36 publications

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“…One may also employ the technique of surface-initiated atom transfer radical polymerization (ATRP) for attaching pHresponsive polymer brushes as done for poly (2-(diethylamino)ethyl methacrylate) (PDEA) and multiresponsive poly (2-(dimethylamino)ethyl methacrylate) (PDMAE-MA). 17 −19 In a similar fashion by this method poly(2-(2methoxyethoxy)ethyl methacrylate) (PMDM) has been attached, thereby yielding nanoparticles possessing a lower critical solution temperature (LCST) in aqueous solution, 20 and this had similarly been reported previously for the case of poly(N-isopropylacrylamide (PNIPAM). 21 In a different approach via vapor deposition polymerization PDMAEMAcoated SiO 2 -NPs have been produced that showed antibacterial properties.…”

Section: Introductionmentioning

confidence: 68%

“…A rather versatile way for different polymer modifications is given by the reversible addition–fragmentation chain transfer polymerization (RAFT) method, which has been shown to allow to attach a large variety of different polymers, which then may also allow to attach polymers that are water-soluble, as aqueous dispersions are particularly interesting for many applications. One may also employ the technique of surface-initiated atom transfer radical polymerization (ATRP) for attaching pH-responsive polymer brushes as done for poly(2-(diethylamino)ethyl methacrylate) (PDEA) and multiresponsive poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA). − In a similar fashion by this method poly(2-(2-methoxyethoxy)ethyl methacrylate) (PMDM) has been attached, thereby yielding nanoparticles possessing a lower critical solution temperature (LCST) in aqueous solution, and this had similarly been reported previously for the case of poly( N -isopropylacrylamide (PNIPAM) . In a different approach via vapor deposition polymerization PDMAEMA-coated SiO 2 -NPs have been produced that showed antibacterial properties .…”

Section: Introductionmentioning

confidence: 99%

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Preparation of Polymer Brush Grafted Anionic or Cationic Silica Nanoparticles: Systematic Variation of the Polymer Shell

et al. 2018

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Polymer brush grafted anionic SiO 2 @PMAA (poly(methacrylic acid)) and cationic SiO 2 @PDMAEMA (poly(2-(dimethylamino)ethyl methacrylate)) inorganic/polymer hybrid nanoparticles with different core radii (d NP = 50− 140 nm) and different amounts of attached polymer were synthesized via surface-initiated atomic transfer radical polymerization (ATRP). To avoid irreversible aggregation, a three-step surface modification had to be employed, thereby keeping the nanoparticles always dispersed. For SiO 2 @PMAA the shell thickness changes with the monomer concentration, while for SiO 2 @PDMAEMA the grafting density was changed by monomer concentration and the shell thickness remained constant. We assume that the control over the grafting density relies on the nature of the complexation potential of the PDMAEMA. The structural characterization of the polymer grafted SiO 2 -NPs was done in detail by different scattering methods combined with thermogravimetric analysis, and details of the brush characteristics are obtained by small-angle neutron scattering (SANS). With this approach we were able to produce silica nanoparticles with anionic and cationic polymer shells, where the softness of the NPs can be controlled by the amount of polymer, which are pH-responsive and colloidally stable over a large pH range.

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Section: Introductionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Preparation of Polymer Brush Grafted Anionic or Cationic Silica Nanoparticles: Systematic Variation of the Polymer Shell

et al. 2018

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“…POEGMA-based TRPBCs demonstrate nonfouling properties, with no adsorbed proteins at all the studied temperatures: BSA adsorption was not observed for PDEGMA TRPBC [ 153 ]. Similar results were presented in the work [ 48 ], in which lentil lectin adsorption to POEGMA246 TRPBC was not observed at T > LCST as well as T < LCST.…”

Section: Advanced Biomedical Applications Of Trpbcsmentioning

confidence: 99%

Temperature-Responsive Polymer Brush Coatings for Advanced Biomedical Applications

et al. 2022

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Modern biomedical technologies predict the application of materials and devices that not only can comply effectively with specific requirements, but also enable remote control of their functions. One of the most prospective materials for these advanced biomedical applications are materials based on temperature-responsive polymer brush coatings (TRPBCs). In this review, methods for the fabrication and characterization of TRPBCs are summarized, and possibilities for their application, as well as the advantages and disadvantages of the TRPBCs, are presented in detail. Special attention is paid to the mechanisms of thermo-responsibility of the TRPBCs. Applications of TRPBCs for temperature-switchable bacteria killing, temperature-controlled protein adsorption, cell culture, and temperature-controlled adhesion/detachment of cells and tissues are considered. The specific criteria required for the desired biomedical applications of TRPBCs are presented and discussed.

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“…The temperature-responsive grafted copolymer brushes, such as poly(Nisopropylacrylamide-co-N-butyl methacrylate), 15 poly(N-isopropylacrylamide-co-acrylic acid-co-tert-butylacrylamide), 16 poly(N-isopropylacrylamide-co-N,N-dimethylaminopropylacrylamide-co-N-butyl methacrylate), 17 poly(N-isopropylacryla-mide-co-N,N-dimethylaminopropylacrylamide-co-N-tert-butylacrylamide), 18 various oligo(ethylene glycol)methacrylates, 19 and poly(N-isopropylacrylamide-co-2-carboxyisopropylacrylamide), modified with cell adhesive peptide 20,21 have been synthesized and very successfully used for the separation of molecules or as thermoresponsive surfaces for cell cultures. The composition of the copolymer brushes has a huge influence on their temperature-responsive properties tuning the low critical solution temperature 22 or blocking temperature-responsive properties. 23,24 Almost all previously reported works demonstrated two-stage temperature-controlled switching where, in general, only two phases can be displayed with a short transition between them.…”

Section: Introductionmentioning

confidence: 99%

Temperature-Controlled Three-Stage Switching of Wetting, Morphology, and Protein Adsorption

Stetsyshyn

Raczkowska

Lishchynskyi

et al. 2017

ACS Appl. Mater. Interfaces

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The novel polymeric coatings of oligoperoxide-graft-poly(4-vinylpyridine-co-oligo(ethylene glycol)ethyl ether methacrylate246) [oligoperoxide-graft-P(4VP-co-OEGMA246)] attached to glass were successfully fabricated. The composition, thickness, morphology, and wettability of resulting coatings were analyzed using X-ray photoelectron spectroscopy, ellipsometry, atomic force microscopy, and contact angle measurements, respectively. In addition, adsorption of the bovine serum albumin was examined with fluorescence microscopy. The thermal response of wettability and morphology of the coatings followed by that of protein adsorption revealed two distinct transitions at 10 and 23 °C. For the first time, three stage switching was observed not only for surface wetting but also for morphology and protein adsorption. Moreover, the influence of the pH on thermo-sensitivity of modified surfaces was shown.

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Temperature-responsive copolymer brush constructed on a silica microparticle by atom transfer radical polymerization

Cited by 9 publications

References 36 publications

Preparation of Polymer Brush Grafted Anionic or Cationic Silica Nanoparticles: Systematic Variation of the Polymer Shell

Preparation of Polymer Brush Grafted Anionic or Cationic Silica Nanoparticles: Systematic Variation of the Polymer Shell

Temperature-Responsive Polymer Brush Coatings for Advanced Biomedical Applications

Temperature-Controlled Three-Stage Switching of Wetting, Morphology, and Protein Adsorption

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