Temperature/pH/Enzyme Triple-Responsive Cationic Protein/PAA-<i>b</i>-PNIPAAm Nanogels for Controlled Anticancer Drug and Photosensitizer Delivery against Multidrug Resistant Breast Cancer Cells

Don, Trong‐Ming; Lu, Kun Ying; Lin, Li Jie; Hsu, Chun‐Hua; Wu, Jui Yu; Mi, Fwu Long

doi:10.1021/acs.molpharmaceut.7b00737

Cited by 49 publications

(26 citation statements)

References 29 publications

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“…This resulted from the specific features of the microenvironment surrounding tumor cells, i.e., low pH, a high level of glutathione, the presence of particular enzymes, and reactive oxygen species. Several studies have been directed towards altering the structure or properties under chemical, physical, or biological environmental changes, including pH, redox potential, enzymes’ activity, temperature, or light [ 113 , 114 , 115 , 116 ]. The response of stimuli-responsive polymers to a given stimulus may result in charge conversion or size changes [ 117 ].…”

Section: Applications Of Oil-core Nanocapsulesmentioning

confidence: 99%

Polymer Capsules with Hydrophobic Liquid Cores as Functional Nanocarriers

et al. 2020

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Recent developments in the fabrication of core-shell polymer nanocapsules, as well as their current and future applications, are reported here. Special attention is paid to the newly introduced surfactant-free fabrication method of aqueous dispersions of nanocapsules with hydrophobic liquid cores stabilized by amphiphilic copolymers. Various approaches to the efficient stabilization of such vehicles, tailoring their cores and shells for the fabrication of multifunctional, navigable nanocarriers and/or nanoreactors useful in various fields, are discussed. The emphasis is placed on biomedical applications of polymer nanocapsules, including the delivery of poorly soluble active compounds and contrast agents, as well as their use as theranostic platforms. Other methods of fabrication of polymer-based nanocapsules are briefly presented and compared in the context of their biomedical applications.

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Section: Applications Of Oil-core Nanocapsulesmentioning

confidence: 99%

Polymer Capsules with Hydrophobic Liquid Cores as Functional Nanocarriers

et al. 2020

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“…One of the main advantages of PDT is the possibility to combine this treatment with other complementary techniques [1]. For instance, combinations with photothermal therapy (PTT), chemotherapy, or immunotherapy have been reported [2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

The Dark Side: Photosensitizer Prodrugs

2019

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Photodynamic therapy (PDT) and photodiagnosis (PD) are essential approaches in the field of biophotonics. Ideally, both modalities require the selective sensitization of the targeted disease in order to avoid undesired phenomena such as the destruction of healthy tissue, skin photosensitization, or mistaken diagnosis. To a large extent, the occurrence of these incidents can be attributed to “background” accumulation in non-target tissue. Therefore, an ideal photoactive compound should be optically silent in the absence of disease, but bright in its presence. Such requirements can be fulfilled using innovative prodrug strategies targeting disease-associated alterations. Here we will summarize the elaboration, characterization, and evaluation of approaches using polymeric photosensitizer prodrugs, nanoparticles, micelles, and porphysomes. Finally, we will discuss the use of 5-aminolevulinc acid and its derivatives that are selectively transformed in neoplastic cells into photoactive protoporphyrin IX.

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“…The tumour microenvironment is usually at a lower pH, higher temperature than the healthy cells, expresses certain enzymes and hence offers multiple responsive at the same time. In this context, Don et al [55] recently prepared a cationic nanogel using protamine-poly(AA-b-NIPAAm) copolymer. These nanogels showed multi-responsiveness as they were able to react to changes in temperature, pH, and presence of certain enzymes.…”

Section: Nanogels As a Responsive Carrier For Cancer Therapymentioning

confidence: 99%

Polymers, responsiveness and cancer therapy

Pethe

Yadav

2019

Artificial Cells, Nanomedicine, and Biotechnology

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A single outcome in a biological procedure at the time of cancer therapy is due to multiple changes happening simultaneously. Hence to mimic such complex biological processes, an understanding of stimuli responsiveness is needed to sense specific changes and respond in a predictable manner. Such responses due to polymers may take place either simultaneously at the site or in a sequential manner from preparation to transporting pathways to cellular compartments. The present review comprehends the stimuli-responsive polymers and multi-responsiveness with respect to cancer therapy. It focuses on the exploitation of different stimuli like temperature, pH and enzymes responsiveness in a multi-stimuli setting. Nanogels and micelles being two of the most commonly used responsive polymeric carriers have also been discussed. The role of multiple stimuli delivery system is significant due to multiple changes happening in the near surroundings of cancer cells. These responsive materials are able to mimic some biological processes and recognize at the molecular level itself to manipulate development of custom-designed molecules for targeting cancer cells.

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Temperature/pH/Enzyme Triple-Responsive Cationic Protein/PAA-b-PNIPAAm Nanogels for Controlled Anticancer Drug and Photosensitizer Delivery against Multidrug Resistant Breast Cancer Cells

Cited by 49 publications

References 29 publications

Polymer Capsules with Hydrophobic Liquid Cores as Functional Nanocarriers

Polymer Capsules with Hydrophobic Liquid Cores as Functional Nanocarriers

The Dark Side: Photosensitizer Prodrugs

Polymers, responsiveness and cancer therapy

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