volume 78, issue 1, P7-16 2009
DOI: 10.5025/hansen.78.7
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Abstract: Hansen's disease is caused by an infection with an intracellular pathogen, Mycobacterium leprae , which mainly inhabits macrophages and Schwann cells. However, little is known about the survival or growth mechanisms of the bacilli in mouse and human macrophages. In the present study, by using radiorespirometry analysis for the evaluation of the viability of M.leprae , we observed that in vitro incubation of M.leprae-infected macrophages at 35°C was more growth permissive than at 37°C, and supplementation with …

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