Temperature compensation of the threshold potential for excitation of the snail bursting neuron

Effects of Cooling on the Response of the Snail Bursting Neuron to Acetylcholine

“…Previous experiments conducted in our laboratory have shown that cooling causes little or no change in membrane potential of the Br neuron of Helix pomatia 4. Cooling of Br neuron reduces its spontaneous parabolic bursting activity, increases the threshold for action potential firing, and broadens the action potential, suggesting that some voltage‐gated conductances or intrinsic membrane properties are affected by cooling 4. Our data demonstrate that fast cooling reduces the amplitude of ACh‐induced current on the Br neuron of Helix pomatia by an unidentified mechanism that does not involve change in the apparent receptor affinity while increasing the time constant of current decay.…”

“…It has been shown that the iontophoretic application of ACh induced dose‐dependent membrane depolarization on Br neurons. Previous experiments conducted in our laboratory have shown that cooling causes little or no change in membrane potential of the Br neuron of Helix pomatia 4. Cooling of Br neuron reduces its spontaneous parabolic bursting activity, increases the threshold for action potential firing, and broadens the action potential, suggesting that some voltage‐gated conductances or intrinsic membrane properties are affected by cooling 4.…”

Effects of Cooling on the Response of the Snail Bursting Neuron to Acetylcholine

“…Previous experiments conducted in our laboratory have shown that cooling causes little or no change in membrane potential of the Br neuron of Helix pomatia 4. Cooling of Br neuron reduces its spontaneous parabolic bursting activity, increases the threshold for action potential firing, and broadens the action potential, suggesting that some voltage‐gated conductances or intrinsic membrane properties are affected by cooling 4. Our data demonstrate that fast cooling reduces the amplitude of ACh‐induced current on the Br neuron of Helix pomatia by an unidentified mechanism that does not involve change in the apparent receptor affinity while increasing the time constant of current decay.…”

“…It has been shown that the iontophoretic application of ACh induced dose‐dependent membrane depolarization on Br neurons. Previous experiments conducted in our laboratory have shown that cooling causes little or no change in membrane potential of the Br neuron of Helix pomatia 4. Cooling of Br neuron reduces its spontaneous parabolic bursting activity, increases the threshold for action potential firing, and broadens the action potential, suggesting that some voltage‐gated conductances or intrinsic membrane properties are affected by cooling 4.…”

Cold Adaptation in Ectotherms: Regulation of Membrane Function and Cellular Metabolism

“…In crayfish leg muscles the resting potential became more negative with heating, primarily due to stimulation of the sodium pump (Prosser and Nelson 1981), while in giant fibers of the earthworm, action potential duration increased tenfold and conduction velocity declined fourfold between 30° and 5°C (Lagerspetz 1973). Cooling of bursting neurons in the snail, Helix pomatia, increased the threshold voltage and reduced the excitability (Zecevic and Pasic 1983). The low temperature suppression of antibody formation in teleosts may also reflect a membrane limitation (Miller and Clem 1984;Clem et al 1984).…”

Effects of Cooling on the Response of the Snail Bursting Neuron to Acetylcholine

“…Previous experiments conducted in our laboratory have shown that cooling causes little or no change in membrane potential of the Br neuron of Helix pomatia 4. Cooling of Br neuron reduces its spontaneous parabolic bursting activity, increases the threshold for action potential firing, and broadens the action potential, suggesting that some voltage‐gated conductances or intrinsic membrane properties are affected by cooling 4. Our data demonstrate that fast cooling reduces the amplitude of ACh‐induced current on the Br neuron of Helix pomatia by an unidentified mechanism that does not involve change in the apparent receptor affinity while increasing the time constant of current decay.…”

“…It has been shown that the iontophoretic application of ACh induced dose‐dependent membrane depolarization on Br neurons. Previous experiments conducted in our laboratory have shown that cooling causes little or no change in membrane potential of the Br neuron of Helix pomatia 4. Cooling of Br neuron reduces its spontaneous parabolic bursting activity, increases the threshold for action potential firing, and broadens the action potential, suggesting that some voltage‐gated conductances or intrinsic membrane properties are affected by cooling 4.…”

Cold Adaptation in Ectotherms: Regulation of Membrane Function and Cellular Metabolism

“…In crayfish leg muscles the resting potential became more negative with heating, primarily due to stimulation of the sodium pump (Prosser and Nelson 1981), while in giant fibers of the earthworm, action potential duration increased tenfold and conduction velocity declined fourfold between 30° and 5°C (Lagerspetz 1973). Cooling of bursting neurons in the snail, Helix pomatia, increased the threshold voltage and reduced the excitability (Zecevic and Pasic 1983). The low temperature suppression of antibody formation in teleosts may also reflect a membrane limitation (Miller and Clem 1984;Clem et al 1984).…”

Effects of Cooling on the Response of the Snail Bursting Neuron to Acetylcholine

“…Previous experiments conducted in our laboratory have shown that cooling causes little or no change in membrane potential of the Br neuron of Helix pomatia 4. Cooling of Br neuron reduces its spontaneous parabolic bursting activity, increases the threshold for action potential firing, and broadens the action potential, suggesting that some voltage‐gated conductances or intrinsic membrane properties are affected by cooling 4. Our data demonstrate that fast cooling reduces the amplitude of ACh‐induced current on the Br neuron of Helix pomatia by an unidentified mechanism that does not involve change in the apparent receptor affinity while increasing the time constant of current decay.…”

“…It has been shown that the iontophoretic application of ACh induced dose‐dependent membrane depolarization on Br neurons. Previous experiments conducted in our laboratory have shown that cooling causes little or no change in membrane potential of the Br neuron of Helix pomatia 4. Cooling of Br neuron reduces its spontaneous parabolic bursting activity, increases the threshold for action potential firing, and broadens the action potential, suggesting that some voltage‐gated conductances or intrinsic membrane properties are affected by cooling 4.…”

Cold Adaptation in Ectotherms: Regulation of Membrane Function and Cellular Metabolism

“…In crayfish leg muscles the resting potential became more negative with heating, primarily due to stimulation of the sodium pump (Prosser and Nelson 1981), while in giant fibers of the earthworm, action potential duration increased tenfold and conduction velocity declined fourfold between 30° and 5°C (Lagerspetz 1973). Cooling of bursting neurons in the snail, Helix pomatia, increased the threshold voltage and reduced the excitability (Zecevic and Pasic 1983). The low temperature suppression of antibody formation in teleosts may also reflect a membrane limitation (Miller and Clem 1984;Clem et al 1984).…”