2014
DOI: 10.1371/journal.pgen.1004181
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Abstract: Bacteriophages (or phages) dominate the biosphere both numerically and in terms of genetic diversity. In particular, genomic comparisons suggest a remarkable level of horizontal gene transfer among temperate phages, favoring a high evolution rate. Molecular mechanisms of this pervasive mosaicism are mostly unknown. One hypothesis is that phage encoded recombinases are key players in these horizontal transfers, thanks to their high efficiency and low fidelity. Here, we associate two complementary in vivo assays… Show more

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Cited by 98 publications
(97 citation statements)
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“…The frequencies of such exchanges in the wild are not known (e.g., George et al , 1983; Haggard-Ljungquist et al , 1992; Sandmeier et al , 1992; Stummeyer et al , 2006; Pickard et al , 2010; Casjens and Thuman-Commike, 2011; Jacobs-Sera et al , 2012), but some measurements have been performed in the laboratory ( e.g. , De Paepe et al , 2014). Such horizontal exchange complicates whole phage genome comparisons and will make any hierarchical classification scheme nonsensical if it is great enough (Lawrence et al , 2002).…”
Section: Introductionmentioning
confidence: 99%
“…The frequencies of such exchanges in the wild are not known (e.g., George et al , 1983; Haggard-Ljungquist et al , 1992; Sandmeier et al , 1992; Stummeyer et al , 2006; Pickard et al , 2010; Casjens and Thuman-Commike, 2011; Jacobs-Sera et al , 2012), but some measurements have been performed in the laboratory ( e.g. , De Paepe et al , 2014). Such horizontal exchange complicates whole phage genome comparisons and will make any hierarchical classification scheme nonsensical if it is great enough (Lawrence et al , 2002).…”
Section: Introductionmentioning
confidence: 99%
“…It has been shown that lambdoid phages are capable of extensive recombination and are prone to mosaicism, in large part due to their encoded recombinase enzyme systems (De Paepe et al, 2014). Because of the status of EHEC strains as important pathogens, and the role of Stx phages in the distribution of their key virulence factors, the Shiga toxins, Stx phages have been widely characterised (García-Aljaro et al, 2009;Smith et al, 2012).…”
Section: Discussionmentioning
confidence: 99%
“…However, the presence of homology with other lambdoid phages in this region does mean that ybcN can serve as a repository of alternative phage genetic material that can be picked up by incoming phage, thus contributing to the ongoing evolution of mosaic genomes [38]. The presence of homologs of the defective prophage DLP12 ybcN gene in functional phage genomes, including 82 and φ 80, suggests that it does specify an active Orf-like protein.…”
Section: Discussionmentioning
confidence: 99%
“…However, recent experiments examining recombinational exchanges between partially homologous partners on phages and prophages, suggest that Orf is required primarily for exchanges promoted by the Red system rather than by RecA [38]. It is possible that RecFOR normally prevail over Orf in mediating the loading of RecA onto ssDNA bound by SSB, whereas the bacterial activities are less active in situations involving the Red system (e.g.…”
Section: Discussionmentioning
confidence: 99%