2015
DOI: 10.18632/aging.100840
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Abstract: PurposeAge induces a progressive decline in functional reserve and impacts cancer treatments. Telomere attrition leads to tissue senescence. We tested the hypothesis that telomere length (TL) could predict patient vulnerability and outcome with cancer treatment.Patients and methodsAn ancillary study in the Elderly Women GINECO Trial 3 was performed to evaluate the impact of geriatric covariates on survival in elderly advanced ovarian cancer patients receiving six cycles of carboplatin. TL was estimated from pe… Show more

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Cited by 9 publications
(6 citation statements)
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References 35 publications
(44 reference statements)
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“…Thus, telomerase-high ovarian CSCs are the most energetically-activated, migratory and proliferative cell sub-population [ 6 ]. These findings suggest a mechanistic interpretation for why long telomere length (a specific marker of high telomerase activity) is strictly correlated with metastasis disease progression and poor outcome in ovarian tumors and other cancer types [ 8 , 9 ].…”
Section: Discussionmentioning
confidence: 99%
“…Thus, telomerase-high ovarian CSCs are the most energetically-activated, migratory and proliferative cell sub-population [ 6 ]. These findings suggest a mechanistic interpretation for why long telomere length (a specific marker of high telomerase activity) is strictly correlated with metastasis disease progression and poor outcome in ovarian tumors and other cancer types [ 8 , 9 ].…”
Section: Discussionmentioning
confidence: 99%
“…However, rate of side effects was also low in this study, at least for some of the toxicities under analysis. In contrast, one study significantly correlated shorter leukocyte TL with higher risk of non-hematological toxicity in elderly ovarian cancer patients, but did not find such association for hematological events [33] . The cohort of this study received carboplatin instead of FEC or FEC-D, so it is possible that the observed correlation is drug-specific.…”
Section: Discussionmentioning
confidence: 81%
“…Short telomere was associated with age, and with treatment completion rates (p=0.02), serious adverse events (p=0.02), and a trend association with unplanned hospital admissions (p=0.08), and OS (p=0.06). There was a trend association with geriatric vulnerability parameters 110.…”
Section: Dna Damage/telomerecell Cycle Regulation/apoptosis/senesmentioning
confidence: 87%