Telomere length, ZNF208 genetic variants and risk of chronic obstructive pulmonary disease in the Hainan Li population

Abstract

Background Chronic obstructive pulmonary disease (COPD) is a disease characterized by airflow limitation. It is not completely reversible and shows progressive development. ZNF208 rs8105767 affects telomere length, although the impact of telomere on COPD is still controversial. In the present study, we aimed to explore the impact of the ZNF208 gene polymorphism on telomere length and also that of telomere length on COPD in the Hainan Li population. Methods In total, 270 COPD patients and 288 controls were recruited. Telomere length was measured by a quantitative real‐time polymerase chain reaction. Five single nucleotide polymorphisms in ZNF208 were selected and genotyping was performed using MassARRAY software (Agena Bioscience Co. Ltd, San Diego, CA, USA). Differences in telomere length among the subjects with three genotypes of related genes were assessed using analysis of variance. Unconditional logistic regression was used to calculate odds ratios (OR) as the indicator of association between telomere length and COPD risk. Results Relative telomere length in the COPD group and control group was 0.66 ± 0.47 and 1.44 ± 0.89, respectively. We grouped according to a median of 0.8284 for telomere length and observed that the risk of COPD for individuals with a telomere length less than 0.8284 is 2.92 times that for individuals with a telomere length longer than 0.8284 (OR = 2.92, 95% confidence interval = 2.01–4.25, p = 1.91 × 10–8). Subjects carrying the G allele of rs2188972 had a longer telomere length. Subjects carrying the carrying the CA genotype of rs8103163 and AC genotype of rs7248488 had a longer telomere length compared to wild‐type individuals. Conclusions Shorter telomeres increase COPD risk and the ZNF208 polymorphism affects telomere length in COPD patients.

Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments

“…Several studies have found that COPD patients have accelerated telomere shortening in leukocytes compared to regular smokers, and morbidity of the disease has been correlated to shorter telomere length [186,187,188]. When looking specifically at relative telomere length in airway epithelial cells from COPD patients, one study found no correlation of shorter telomere length with the disease.…”

Immunosenescence and Inflammation in Chronic Obstructive Pulmonary Disease: A Systematic Review

“…Forty-one (41) were retained after the reading of titles and abstracts. Twenty-six (26) of these were excluded due to lacking eligibility criteria: eight studies were excluded as a result of statistically significant differences in age between COPD patients and controls [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]; three were excluded due to the investigation of biomarkers in lung or muscular tissue [ 30 , 31 , 32 ]; five studies had no control group [ 17 , 33 , 34 , 35 , 36 ]; three did not report the results of statistical testing for discrepancies in age between COPD patients and controls [ 37 , 38 , 39 ]; and one did not perform comparisons [ 40 ]. Two articles employed a study design that was inconsistent with the stated eligibility criteria [ 41 , 42 ].…”

A retrospective case-control study for Clinical Validation of mutated ZNF208 as a novel biomarker of fatal blast crisis in Chronic Myeloid Leukemia

“…These ZFPs have the potential to be used in the development of a predictive gene signature, which could have prognostic value in relation to ovarian cancer and its response to PARP inhibitors. The sources cited for this information are [54,62,[63][64][65][66].…”