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Cited by 6 publications
(13 citation statements)
References 8 publications
(13 reference statements)
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“…6 The identified SNPs in these genes do not account for a large proportion of risk in either melanoma or glioma, but there is evidence that innate telomere length and variation in telomere maintenance pathways may contribute to risk in both diseases. 57 When pathway analyses were re-run using single-SNP results conditioned on known GWAS hits, pathway associations no longer reached the significance threshold. Genespecific P-values for TERT, EGFR, and RTEL1 were lowest for conditional analyses performed in Pascal, the algorithm used to calculate pathway scores compared with the other 2 algorithms.…”
Section: Ostrom Et Al Sex-specific Germline Gene and Pathway Analysis...mentioning
confidence: 99%
“…6 The identified SNPs in these genes do not account for a large proportion of risk in either melanoma or glioma, but there is evidence that innate telomere length and variation in telomere maintenance pathways may contribute to risk in both diseases. 57 When pathway analyses were re-run using single-SNP results conditioned on known GWAS hits, pathway associations no longer reached the significance threshold. Genespecific P-values for TERT, EGFR, and RTEL1 were lowest for conditional analyses performed in Pascal, the algorithm used to calculate pathway scores compared with the other 2 algorithms.…”
Section: Ostrom Et Al Sex-specific Germline Gene and Pathway Analysis...mentioning
confidence: 99%
“…48,49 including SNPs in the regions surrounding CDNK2A and TERT that have been previously associated with glioma. 4 These SNPs do not account for a large proportion of risk in either cancer type, but there is some evidence that telomere length and pathways of telomere maintenance may contribute to risk in both diseases 50 .…”
Section: Discussionmentioning
confidence: 99%
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