2015
DOI: 10.18632/aging.100814
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Abstract: BackgroundReplicative senescence, associated with telomere shortening, plays an important role in aging and cardiovascular disease. The relation between telomere length, cardiovascular risk, and renal disease is unknown.MethodsOur study consisted of a cohort of 257 kidney donors for transplantation, divided into a test and a validation cohort. We used quantitative RT‐PCR to measure relative telomere length (log T/S ratio) in peripheral blood leucocytes, and in kidney biopsies performed prior to implantation. T… Show more

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Cited by 18 publications
(34 citation statements)
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References 32 publications
(34 reference statements)
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“…In other words, shorter telomeres possibly contribute to increased renal injury and decreased recovery after damage [ 132 , 136 ]. Finally, it should be noted that De Vusser et al demonstrated an association between shorter leucocyte telomere length and arteriosclerosis in smaller intrarenal arteries suggesting a central role of replicative senescence in the progression of renovascular disease [ 137 ]. Current data support a connection of telomeres and telomerase in the chronic inflammatory status of renal failure though the exact connection still remains unknown and more studies are needed in order for every molecular aspect of this connection to be uncovered.…”
Section: The Telomere/telomerase System In Chronic Disorders Is Imentioning
confidence: 99%
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“…In other words, shorter telomeres possibly contribute to increased renal injury and decreased recovery after damage [ 132 , 136 ]. Finally, it should be noted that De Vusser et al demonstrated an association between shorter leucocyte telomere length and arteriosclerosis in smaller intrarenal arteries suggesting a central role of replicative senescence in the progression of renovascular disease [ 137 ]. Current data support a connection of telomeres and telomerase in the chronic inflammatory status of renal failure though the exact connection still remains unknown and more studies are needed in order for every molecular aspect of this connection to be uncovered.…”
Section: The Telomere/telomerase System In Chronic Disorders Is Imentioning
confidence: 99%
“…Moreover, telomere biology has also been linked to hypertension since telomere shortening significantly contributes to increased pulse pressure and pulse wave velocity in male patients, while hypertension also in men has been associated with shorter leucocyte telomere length [ 146 ]. Intrarenal arteriosclerosis has also been associated with shorter leucocyte telomere length, indicating that replicative senescence plays a central role in the progression of renovascular disease, independent of calendar age [ 137 ]. Shorter leucocyte telomere length has also been associated with increased concentrations of certain inflammation markers such as oxLDL, CRP and IL-6 [ 147 ].…”
Section: The Telomere/telomerase System In Chronic Disorders Is Imentioning
confidence: 99%
“…Telomeres shorten with every cell division during replicative senescence, which is involved in renal ageing [ 18 ]. In the follow-up of CKD patients with a history of smoking and a history of diabetes, it was found that the CKD risk increased by 44% and 16%, respectively, per 0.1 unit decrease in the telomere length of peripheral blood mononuclear cells [ 19 ].…”
Section: Cellular Senescence In Chronic Kidney Diseasementioning
confidence: 99%
“…In uraemic predialysis patients, the telomere length of lymphocytes was significantly shorter than that in the control, suggesting the existence of replicative senescence [ 21 ]. In uraemic patients undergoing haemodialysis or renal transplantation, the lymphocytes showed shorter telomere lengths and secreted large amounts of inflammatory molecules [ 18 , 21 , 22 ]. Moreover, with the extension of dialysis duration, the telomere length of peripheral blood mononuclear cells gradually shortened, and the expression of p53 correspondingly increased [ 23 ].…”
Section: Cellular Senescence In Chronic Kidney Diseasementioning
confidence: 99%
“…Second, selected mechanisms of the aging process are more evident in COPD patients; for instance, telomere shortening of pneumocytes and pulmonary endothelial cells is dramatically increased in COPD patients even after age 70 years . Similarly, renal arteriosclerosis was recently found to be associated with shorter leukocyte and renal cells telomere length . Third, age‐related loss of efficiency of reparative processes makes the aged lung and kidney at special risk of damage secondary to exposure to selected risk factors, such as smoking or inflammation.…”
Section: Mechanisms For Coexisting Ckd and Copd: Does Age Modulate Thmentioning
confidence: 99%