volume 7, issue 10, P766-775 2015
DOI: 10.18632/aging.100814
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Katrien De Vusser, Nicky Pieters, Bram Janssen, Evelyne Lerut, Dirk Kuypers, Ina Jochmans, Diethard Monbaliu, Jacques Pirenne, Tim Nawrot, Maarten Naesens

Abstract: BackgroundReplicative senescence, associated with telomere shortening, plays an important role in aging and cardiovascular disease. The relation between telomere length, cardiovascular risk, and renal disease is unknown.MethodsOur study consisted of a cohort of 257 kidney donors for transplantation, divided into a test and a validation cohort. We used quantitative RT‐PCR to measure relative telomere length (log T/S ratio) in peripheral blood leucocytes, and in kidney biopsies performed prior to implantation. T…

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