Telocytes in human oesophagus

Chen, Xiaoke; Zheng, Yonghua; Manole, Catalin G.; Wang, Xiangdong; Wang, Qun

doi:10.1111/jcmm.12149

Cited by 65 publications

(66 citation statements)

References 55 publications

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“…Telocytes have been detected in many organs , and we recently identified renal TCs in the renal cortex . However, the biological function of these cells remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Renal telocytes contribute to the repair of ischemically injured renal tubules

Lin

et al. 2014

J Cellular Molecular Medi

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Telocytes (TCs), a distinct type of interstitial cells, have been identified in many organs via electron microscopy. However, their precise function in organ regeneration remains unknown. This study investigated the paracrine effect of renal TCs on renal tubular epithelial cells (TECs) in vitro, the regenerative function of renal TCs in renal tubules after ischaemia–reperfusion injury (IRI) in vivo and the possible mechanisms involved. In a renal IRI model, transplantation of renal TCs was found to decrease serum creatinine and blood urea nitrogen (BUN) levels, while renal fibroblasts exerted no such effect. The results of histological injury assessments and the expression levels of cleaved caspase-3 were consistent with a change in kidney function. Our data suggest that the protective effect of TCs against IRI occurs via inflammation-independent mechanisms in vivo. Furthermore, we found that renal TCs could not directly promote the proliferation and anti-apoptosis properties of TECs in vitro. TCs did not display any advantage in paracrine growth factor secretion in vitro compared with renal fibroblasts. These data indicate that renal TCs protect against renal IRI via an inflammation-independent pathway and that growth factors play a significant role in this mechanism. Renal TCs may protect TECs in certain microenvironments while interacting with other cells.

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“…Telocytes have been detected in many organs , and we recently identified renal TCs in the renal cortex . However, the biological function of these cells remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Renal telocytes contribute to the repair of ischemically injured renal tubules

Lin

et al. 2014

J Cellular Molecular Medi

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“…The microRNA signatures as well as the gene profiles were described . Moreover, TCs with similar ultrastructural and phenotypic characteristics were found in many organs . Thus, it leads us to hypothesize that TCs may exist in all organs .…”

Section: Introductionmentioning

confidence: 94%

“…Telocytes (TCs), a special type of interstitial cells, have been identified by Popescu's group and the concept of TCs has been adopted by many laboratories worldwide (for details visit http://www.telocytes.com). Telocytes are described as interstitial cells with extremely long and thin prolongations, called telopodes (Tps) .…”

Section: Introductionmentioning

confidence: 99%

Telocytes in human heart valves

Yang

Sun

et al. 2014

J Cellular Molecular Medi

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Valve interstitial cells (VICs) are responsible for maintaining the structural integrity and dynamic behaviour of the valve. Telocytes (TCs), a peculiar type of interstitial cells, have been recently identified by Popescu*s group in epicardium, myocardium and endocardium (visit http://www.telocytes.com). The presence of TCs has been identified in atria, ventricles and many other tissues and organ, but not yet in heart valves. We used transmission electron microscopy and immunofluorescence methods (double labelling for CD34 and c-kit, or vimentin, or PDGF Receptor-β) to provide evidence for the existence of TCs in human heart valves, including mitral valve, tricuspid valve and aortic valve. TCs are found in both apex and base of heart valves, with a similar density of 27–28 cells/mm2 in mitral valve, tricuspid valve and aortic valve. Since TCs are known for the participation in regeneration or repair biological processes, it remains to be determined how TCs contributes to the valve attempts to re-establish normal structure and function following injury, especially a complex junction was found between TCs and a putative stem (progenitor) cell.

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“…TCs have been described in the interstitium of certain parenchimatous organs in mammals (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) and, although ICCs have been identified in the digestive tract of turkeys (23) and in the intestine of chickens (24), the presence of ICLCs or TCs in the digestive system of the chicken remains unclear. In addition, Cantarero Carmona et al (25) described TCs at the intestinal level, in the lamina propria of rat duodenum; however, to the best of our knowledge, studies on TCs in the intestinal muscularis have not previously been conducted.…”

Section: Introductionmentioning

confidence: 99%

Ultrastructural identification of telocytes in the muscularis of chicken ileum

Yang

Liu

Ahmed

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Telocytes (TCs) are a specialized type of interstitial cells, characterized by a small cell body and long, thin processes, that have recently been identified in various cavitary and non-cavitary organs of humans and laboratory mammals. Chickens present significant economical and scientific notability; however, ultrastructural identification of TCs remains unclear in birds. The aim of the present study was to describe electron microscopic evidence for the presence of TCs in the chicken gut. The ileum of healthy adult broiler chickens (n=10) was studied by transmission electron microscopy. TCs are characterized by several, long (tens to hundreds of µm) prolongations called telopodes (Tps). Tps, which are below the resolving power of light microscopy, display podomeres (thin segments of ≤0.2 µm) and podoms (dilations accommodating caveolae, mitochondria and endoplasmic reticulum). TCs were observed in every field, but were predominantly located in the myenteric plexus and the lamina propria. Tps frequently establish close spatial relationships with immune cells, blood vessels and nerve endings. On the basis of their distribution and morphology, it was hypothesized that the different locations of TCs may be associated with different roles.

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Telocytes in human oesophagus

Cited by 65 publications

References 55 publications

Renal telocytes contribute to the repair of ischemically injured renal tubules

Renal telocytes contribute to the repair of ischemically injured renal tubules

Telocytes in human heart valves

Ultrastructural identification of telocytes in the muscularis of chicken ileum

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