Tei index (myocardial performance index) and cardiac biomarkers in dogs with parvoviral enteritis

Kocatürk, Meriç; Martínez, Silvia; Eralp, Oya; Tvarijonaviciute, Asta; Cerón, José J.; Yılmaz, Zeki

doi:10.1016/j.rvsc.2010.10.018

Cited by 27 publications

(33 citation statements)

References 38 publications

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“…Previous studies in veterinary patients found similar results 6, 12, 15, 20. In a study of 85 dogs with GDV, 87% had detectable concentrations of cTnI and cTnI was increased in all dogs that did not survive.…”

Section: Discussionsupporting

confidence: 69%

“…Several noncardiac diseases can lead to secondary myocardial injury, which accentuates the importance of monitoring cardiac function. Myocardial injury can be detected by measuring cardiac troponin I (cTnI) or cardiac troponin T (cTnT) concentrations, and has been reported in dogs with gastric dilatation volvulus (GDV),4, 6 ehrlichiosis,8, 9 babesiosis,10, 11, 12 leishmaniasis,13 pyometra,14, 15 snake envenomation,16 kidney diseases,17, 18 noncardiac causes of respiratory distress,19 and canine parvovirosis 20…”

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confidence: 99%

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Serum Cardiac Troponin I Concentrations in Dogs with Systemic Inflammatory Response Syndrome

Hamacher¹,

Dörfelt²,

Müller³

et al. 2015

Veterinary Internal Medicne

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BackgroundMyocardial injury can be detected by cardiac troponin I (cTnI) concentration, which appears to be a predictor of short‐term death in critically ill patients. It is unknown if the best prognostic indicator of short‐term survival is cTnI measurement at admission or at later time points.Hypothesis/ObjectivesMeasuring cTnI with a high‐sensitivity (HS) test at different time points after admission may be a better short‐term prognostic indicator than a single cTnI measurement at admission in dogs with systemic inflammatory response syndrome (SIRS).AnimalsProspective, observational clinical study of 60 dogs with SIRS.MethodsCardiac troponin I concentration was measured in 133 serum samples, collected at days 1, 2, 3, and 5. Additionally, the acute patient physiologic and laboratory evaluation (APPLE) fast score was evaluated at admission. Prognostic capabilities of cTnI measurement and APPLE fast score for 28‐day mortality were assessed by receiver operating characteristic curve analysis.ResultsForty‐one dogs with SIRS that survived 28 days had significantly lower serum cTnI concentrations at admission (median, 0.09 ng/mL; P = .004) and at the peak time point (median, 0.23 ng/mL; P = .01) compared to 19 nonsurvivors (median at admission, 0.63 ng/mL; median at peak, 1.22 ng/mL). Area under the curve to predict survival, using cTnI was similar at admission (0.732) and at peak (0.708), and was 0.754 for the APPLE fast score.Conclusions and Clinical ImportanceIncreased cTnI concentration in dogs with SIRS is associated with poor outcome. Daily follow‐up measurement of cTnI concentration provides no additional prognostic information for short‐term mortality.

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Section: Discussionsupporting

confidence: 69%

mentioning

confidence: 99%

Serum Cardiac Troponin I Concentrations in Dogs with Systemic Inflammatory Response Syndrome

Hamacher¹,

Dörfelt²,

Müller³

et al. 2015

Veterinary Internal Medicne

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“…Regarding its use in prognostication, an investigation that included dogs with parvoviral enteritis found higher values of the Tei index in survivors as compared to the non-surviving animals. Curiously, the sensitivity and specificity of the index to predict mortality in that study was higher than those attained by cardiac troponin I (Kocaturk et al 2012).…”

Section: Introductionmentioning

confidence: 64%

Tei index of myocardial performance in conscious healthy Beagles

et al. 2016

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ABSTRACT. The Tei index of myocardial performance is a noninvasive echocardiographic parameter that combines systolic and diastolic time intervals to assess global cardiac performance. It was demonstrated to be a reliable indicator of myocardial dysfunction in dogs with varying clinical conditions. Because only a few studies focused on the measurement of the index in healthy dogs, this cross-sectional study was conceived to investigate how it performs in a large population of clinically healthy Beagle dogs. Our results showed no correlation between the index and body weight, heart rate, and several standard echocardiographic measures which are estimates of preload and afterload. There was no difference between de index calculated for males or females. Also, results indicated strong intra-observer and inter-observer correlations. In conclusion, the Tei index was shown to perform independently of loading conditions, besides being a straightforward and easily reproducible parameter.Key words: echocardiography, cardiac function, Doppler, dog. RESUMEN.El índice de rendimiento miocárdico es un parámetro ecocardiográfico no invasivo que combina intérvalos de tiempo sistólico y diastólico para evaluar el rendimiento cardiaco total. Se ha demostrado que es un indicador fiable de disfunción miocárdica en perros con diferentes condiciones clínicas. Debido a que pocos estudios se centraron en la medición de este índice en perros sanos, este estudio transversal fue concebido para investigar este rendimiento en una gran población de perros Beagle clínicamente sanos. Nuestros resultados no muestran correlación entre el índice y el peso corporal, la frecuencia cardiaca, y varias medidas ecocardiográficas que son estimaciones estándar de precarga y poscarga. No hubo diferencia entre machos y hembras para el índice calculado. Además, los resultados indicaron notorias correlaciones intraobservador e interobservador. En conclusión, el índice de Tei se mostró como un parámetro independiente de las condiciones de la carga, que además de ser fácil de calcular también es un parámetro de fácil reproducción.

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“…Se ha determinado qué patologías extracardiacas que pueden producir un aumento notable de la tni en perros, posiblemente debido a lesión cardiaca secundaria a hipoxia o toxicosis, incluyen la piómetra, la parvovirosis [22], el síndrome de dilatación y el vólvulo gástrico (dtg), el derrame pericárdico [23], los traumatismos y las septicemias. Las miocarditis asociadas a babesia o tripanosoma [4], así como los perros positivos a Bartonella spp [24], pueden tener un aumento de hasta 100 veces su valor; igualmente, se han detectado incrementos en los niveles de tni en perros sanos sometidos a anestesia general [25].…”

Section: Troponinas Cardiacasunclassified

Biomarcadores cardiacos como ayuda diagnóstica en las cardiopatías

Salgado

Arango

2014

Spei Domus

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En la clínica diaria de pequeños animales, es común encontrarse con patologías cardiacas, para cuyo diagnóstico se utilizan técnicas imagenológicas como la radiografía, el electrocardiograma y la ecocardiografía. Sin embargo, a pesar de la amplia investigación sobre estas técnicas, todavía es difícil establecer con claridad el pronóstico de estos pacientes y evaluar objetivamente la evolución de dichas patologías; incluso, existen pacientes con cardiopatías ocultas que pueden pasar inadvertidas al examen clínico y a las ayudas imagenológicas. Es por este motivo que en los últimos años se vienen estudiando nuevos métodos para diagnosticar cardiopatías de forma rápida y eficaz; es el caso de los biomarcadores cardiacos, como las troponinas y los péptidos natriuréticos, que en medicina humana y animal se usan cada vez más para ayudar a establecer el diagnóstico, el pronóstico y la evolución de problemas cardiacos, con alta especificidad y sensibilidad. El presente artículo pretende actualizar los conceptos sobre el manejo de biomarcadores cardiacos en el diagnóstico cardiológico de perros y gatos.

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Tei index (myocardial performance index) and cardiac biomarkers in dogs with parvoviral enteritis

Cited by 27 publications

References 38 publications

Serum Cardiac Troponin I Concentrations in Dogs with Systemic Inflammatory Response Syndrome

Serum Cardiac Troponin I Concentrations in Dogs with Systemic Inflammatory Response Syndrome

Tei index of myocardial performance in conscious healthy Beagles

Biomarcadores cardiacos como ayuda diagnóstica en las cardiopatías

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